The Snedeker Lab

The twitter account of Prof. Snedeker's Laboratory for Orthopaedic Biomechanics at D-HEST @ETH_en, @uzh_news_en and @DerBalgrist

[The Snedeker Lab @SnedekerLab]

Out today in Nature Communications: @Amro_Hussien shows that tendon fibrosis in systemic sclerosis is mechanically gated.

We link elevated matrix tension to myofibroblast activation, suppressed collagen transcription, and rewired stromal–immune crosstalk.
https://t.co/RS1rGJjczZ

[The Snedeker Lab @SnedekerLab]

Submolecular modulation of PIEZO1 mechanotransduction with wireless ta... https://t.co/w8WotGLDP1 ☝️💪

[The Snedeker Lab @SnedekerLab]

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment | Science Translational Medicine https://t.co/sVUuGMiNFZ

Important work with @KatrienDeBock, driven by @MoschiniGreta.

@snsf_ch | @derbalgrist | @UZH_en

[The Snedeker Lab @SnedekerLab]

This model approaches tissue-level thresholds (~3 %) seen in explants (Passini et al., Nat BME 2021).
#tendon #mechanobiology #ECM #cellmatrix #ActaBiomaterialia

[The Snedeker Lab @SnedekerLab]

Excited to share one of our lab’s most important papers in Acta Biomaterialia! (Patrick Jaeger, lead author).
We present a 2D/3D tendon-sheet model of wound healing showing how ECM maturation and cross-linking tune tendon cell strain sensitivity.
🔗 https://t.co/avt04YD9by

[The Snedeker Lab @SnedekerLab]

Blocking cross-linking with BAPN stalls adaptation (~15 %). In ECM-poor (ascorbate-free) sheets, cells adhere well yet no Ca²⁺ response even > 20 % strain.

[TENET COST Action @TENET_COST]

🚀 Big News! Our comprehensive review on Achilles Tendinopathy is out in Nature Reviews Disease Primers! 📖💡

🦵 Dive into the latest on pathophysiology, diagnosis & treatment. Huge thanks to our CostAction for supporting collaboration!

🔗 Read here: https://t.co/0XpVtJZdVJ

[The Snedeker Lab @SnedekerLab]

FiberLock technology achieves the long-standing challenge of bearing physiological disc loads without re-herniation. Congrats to the lead author Esteban Ongini & thanks to Sarah Gullbrand @MauckLabfor the amazing collaboration.
DOI: https://t.co/wFQE1kh31B

[The Snedeker Lab @SnedekerLab]

Excited to share our latest publication in @eLife: https://t.co/DQYnYGE7FC Our study uncovers how IL-6/JAK/STAT signaling contributes to tendinopathy by activating fibroblasts. Kudos to Tino Stauber & the team!

[Serena Bonaretti @serenabonaretti.bsky.social @SerenaBonaretti]

We are looking for an enthusiastic Research Software Engineer for a fixed-term position. Your contribution will be fundamental to advance the impact of open-source software for musculoskeletal image analysis! Contact me! Please, repost!
#researchsoftwareengineer #opensource

[The Snedeker Lab @SnedekerLab]

Thanks Tino (and @MWolleb) for the detailed map on how to use tendon assembloids to unlock secrets of cellular crosstalk across tissue compartments....

[The Snedeker Lab @SnedekerLab]

Thanks to the @ors_tendon section (and @awad_lab for the photo). And a huge congratulations to the winners, including our own Maja Wolleb. Nice!

[Hani Awad ❄️ @Awad_Lab]

@ors_tendon section #ORS2024 award winners

[Balgrist University Hospital @derbalgrist]

Congratulations to Prof. Mazda Farshad for winning the Unified Experiences Trailblazer Award from #Cisco! We are delighted to receive the award and to be included in the Cisco Country Digital Acceleration Program with our @OperatingRoomX @CiscoInsider

https://t.co/NpToOhooP8

[The Snedeker Lab @SnedekerLab]

@SheynLab @Julia_Sheyn @jboerckel @WensenJiang @WafaTawackoli @GiselleKaneda @TYuanzhang @GawriLab What a great table. Thanks Dima for the fantastic meal!

[Manuela E. Gomes @ManuelaEGomes]

Excited to be organizing this Session at the TERMIS World Meeting in Seattle with Nathaniel Dyment and having Jess Snedeker as invited speaker! Submit your abstract, deadline is approaching soon! @TERMISAM @DymentLabPenn @SnedekerLab

[Marcy Zenobi-Wong @ZenobiWongLab]

The Department of Health Sciences and Technology @ETH_en is recruiting an Assistant Professor (Tenure Track) of Musculoskeletal Bioengineering. More information at https://t.co/U60K2V2J3T

Please repost !

[The Snedeker Lab @SnedekerLab]

One step closer in understanding how tendon mechanotransduction drives functional tendon adaptation and increases human performance. #Tendon #Mechanobiology #Genetics #Performance

[The Snedeker Lab @SnedekerLab]

Congratulations to Tobias Götschi and friends - a newly published human study directly linking PIEZO1 gain of function to increased patellar tendon stiffness: https://t.co/UDFvxooIXW

[The Snedeker Lab @SnedekerLab]

Congratulations to Tobias Götschi and friends - a newly published human study directly linking PIEZO1 gain of function to increased patellar tendon stiffness: https://t.co/UDFvxooIXW

[Neal L Millar @TendonGlasgow]

A tour de force of the enthesis and tendinopathy with basic science and clinical insights. Thanks to @TheLancetRheum team for all the help …. @UofGMVLS @UofGSii @UofGlasgow ….from me personally a huge thanks 🙏 to the team … fantastic work 🎉👏👏👏