Southampton Paediatric IBD

Southampton Paediatric Inflammatory Bowel Disease Research Group

[Idan Goren @IBD_GorenMD]

From association to prediction: NOD2 as a genomic biomarker to predict high-risk stricturing #crohns
https://t.co/nWpEeANQVB

[James Ashton @James__Ashton]

Really excited to see this in print. The first of (hopefully many) uses of genomics to predict outcomes in #IBD

Translational science funded by @ESPR_EBN

[James Ashton @James__Ashton]

Prediction of Crohn’s Disease Stricturing Phenotype Using a NOD2-derived Genomic Biomarker @IBDJournals

NOD2 = risk stratifies patients at diagnosis -> #Personalisedmedicine based on stricturing risk

@RMBeattie50 @DrLECB @SotonChildHosp @UoS_Medicine
https://t.co/P3jtNcp1v9

[James Ashton @James__Ashton]

NOD2 in #crohnsdisease - we know everything right? Wrong! It's unfinished business
-> Translational potential
-> Role for rare variation
-> Really a #monogenic cause of disease?

Read our article in JCC @RMBeattie50 @DrLECB @SotonChildHosp @UoS_Medicine

https://t.co/lgedv5Yxhk

[Anjan Dhar @anjan_dhar6]

A fantastic paper on the role of NOD2 in the pathogenesis of ileal Crohn’s disease and the inflammasome. Enjoyed reading this on a sunny Saturday morning. Thank you. 👇

[James Ashton @James__Ashton]

On #WorldIBDDay2022 I would like to thank all of our patients, families + staff for contributing to 10+ years of #paediatric #IBD research

There are more patients every year but there are more treatments, and we are closer to personalising management -> @RMBeattie50 @Soton_PIBD

[Ildiko ☕️ @IldikoMe]

Some thought-provoking insights and I really appreciate papers that put 🧩 pieces together and tell a story

💭Hypoimmune / altered inflammatory pathways involved in bacterial clearance and autophagy not new ideas but 🔑 to unpack and get to a ⤵️

💡“precise molecular diagnosis”

[James Ashton @James__Ashton]

Headlines
>Variation in NOD2-related genes = hypoimmune transcription in NOD-pathway
>Contribution of common + rare variation
>Method to cluster patients by molecular subtype
>NOD2 = key for Crohn's disease, more than the 3 commonly associated variants

Open access @IBDJournals

[Yoni - יוני (and Rebecca too) @Primary_Immune]

Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB... in Pediatric Inflammatory Bowel Disease https://t.co/2iAgOeUKGw #bioinformatics #itrtg #mednews #rstats #IBD #crohns #colitis

[Mark Beattie @RMBeattie50]

Great to be part of this important work with James Ashton and Sarah Ennis
@RMBeattie50 @James__Ashton @Soton_PIBD @SotonChildHosp @UHSFT @unisouthampton
#IBD

[Mark Beattie @RMBeattie50]

Great to be part of this important work @RMBeattie50 @James__Ashton @Soton_PIBD @SotonChildHosp @UHSFT @unisouthampton #IBD

[James Ashton @James__Ashton]

Delighted to see this published @IBDJournals, merging WES + RNAseq -> impact of variants in multiple genes

Deleterious variation in the NOD-pathway reduces NFKB-transcription and upregulates alternative inflammatory transcripts in Pediatric #IBD

https://t.co/f0eez5ud81

[James Ashton @James__Ashton]

#ArtificialIntelligence + #MachineLearning + #IBD practicalities + future prospects

->Evidence to date
->What about patient benefit?
->Genomics/Endoscopy/Precision Medicine

Wonderful collaboration @johanne_brooks @BritSocGastro @ibdseb @FrontGastro_BMJ

https://t.co/RqIIg74KHU

[Southampton Paediatric IBD @Soton_PIBD]

Get in touch with your thoughts and priorities, what would make research more appealing and how we can make involvement a positive experience

Looking for patients/families willing to steer our research strategy over the next 2-5 years.

Get in touch @Soton_PIBD @SotonChildHosp

[James Ashton @James__Ashton]

We're looking for patient + public involvement in shaping personalised medicine research in #IBD

-What are your priorities for the future of IBD treatment?
-What should the focus be?
-Do you want to steer the direction of our research?

Get in touch @Soton_PIBD with suggestions

[James Ashton @James__Ashton]

We're looking for patient + public involvement in shaping personalised medicine research in #IBD

-What are your priorities for the future of IBD treatment?
-What should the focus be?
-Do you want to steer the direction of our research?

Get in touch @Soton_PIBD with suggestions

[James Ashton @James__Ashton]

Nutritional assessment in #IBD but what is the role of bioelectrical impedance?
> In stable patients it does not identify active disease or poor nutrition
> Must be aware of overweight individuals = common
Thanks to @ESPENorg @RMBeattie50 @SotonChildHosp
https://t.co/jazBbQfvUv

[James Ashton @James__Ashton]

Our fantastic nurse specialists @rachieroo80 and Jo H are completing the Jurassic coast challenge and raising money for @CrohnsColitisUK this weekend

If you can spare any money -> https://t.co/3MCWlbzqzc

[James Ashton @James__Ashton]

Delighted to present our #IBD work @SouthamptonBRC seminar with @ImogenStafford and Guo Cheng on behalf of @RMBeattie50 and Sarah Ennis

Thanks to all those who have contributed and supported @UHSFT @UoS_Medicine, especially all the patients
#MachineLearning #personalisedmedicine

[James Ashton @James__Ashton]

Excited to see our UK-wide collaborative paper on #transition services in #IBD published in @JPGNonline

Huge thanks to @RMBeattie50 @rafeeq_rm @DrJennyEpstein and many others @BSPGHAN

https://t.co/PiCet4on6j

[IBDJournal & CC360 @IBDJournals]

In a meta-analysis of 6715 pts w/ #CD, Dr. Laffin @UAlbertaSurgery demonstrates, NOD2 risk-allele is associated w/ post-op recurrence in #CD w/ OR 1.64. This study examined all known genetic loci 154 linked to postop recurrence of CD @sivashivi
https://t.co/Xee9jvTFUT