Podocyte gluttony: Incidental finding in 64 yo F with AKI. Super-constipated podocytes (Mega-Chang Bodies 😂) after Thanksgiving dinner, STUFFED with lipid inclusions. Puzzling, until patient said "Oh, I forgot to tell you I have lupus!". Plaquenil-associated phospholipidosis 🤦♀️
Striking biopsy in pt with nephrotic syndrome, hx of IVDU and HCV. Massive AA amyloidosis. Amyloid spicules by EM with amyloid uptake by podocytes and spillage into urinary space. #renalpath#nephropath
Another example of podocyte dusting with IgG in a case of diffuse podocytopathy (MCD) relapse ~1 week after COVID19 booster. Also some low grade IgA deposition. Diffuse podocyte FPE. #renalpath#nephropath
Alexander Tanguay and Meira Weese roll up their sleeves and get their COVID-19 shots at the first vaccine clinic for kids 5 to 11 today in Napanee! Thank you for helping make #KFLAStrong. Book your appointment today: https://t.co/ezxFErCUki
ALL: Never quite seen anything like this in a COVID patient and AKI. I was expecting just ATN. Instead saw a sea of blue cells separating tubules. Work-up revealed acute lymphoblastic lymphoma/leukemia (ALL). 35-yr old previously healthy man with recent history of COVID pneumonia
MBUO (Myeloid Bodies of Unknown Origin): 47 HF with malignant hypertension and acute renal failure. Bx with impressive vascular TMA changes and lots of these lipid inclusions ONLY in mesangial and endothelial cells (NOT in podocytes). No known drug/toxin exposure. 🤷♀️ @ldcornell
Learned a lot from @ldcornell today at @GlomCon about antibody-mediated rejection. /1
Let's start with the 3 main features of ABMR:
(1) microvascular inflammation
(2) C4d
(3) DSA or non-DSA Abs
Touched by lupus: I don't know why some deposits seem to organize into these "fingerprint" structures more than others, but I've seen them in all stages and all locations... And the saying holds true, even for gloms: No one's fingerprints are exactly the same as anyone else's!
Today's Two-fer: 78 yo M with HTN, biopsied for worsening renal function. Surprise: light chain deposition disease AND light chain crystalline tubulopathy, both lambda associated. SPEP confirmed IgG-lambda spike.
Today is the Day!! Do not miss the opportunity to learn about new approach and current treatments of glomerular diseases. Online course starting today!!
Are you joining us!
Staringhttps://evimed.net/en/glomerular2021/
Membranous nephropathy with extensive TBM deposits is a distinctive clinicopathologic lesion associated with allogeneic hematopoietic cell transplant https://t.co/BOhitajIHX
Textbook Lupus Nephritis: It's not often I see such picturesque examples all in the same biopsy, like one-stop shopping for LN pathology! Endocapillary hypercellularity, wire loops and "hyaline thrombi", crescents and necrosis, and everyone's favorite, hematoxylin bodies...
Excited to have our undergraduate Life Sciences students back on campus at Queen's. Dr Susan Crocker welcomed our PMM Human Genetics class for the first time in 18 months. So great to see you all face to face again!