The Spang Lab

We are scientists interested in understanding the basics of how a cell, the building block of our body, works. @biozentrum @UniBasel_en #cellbio #Biozentrum

[The Spang Lab @Spang_Lab]

wonderful work by Jachen Solinger @biozentrum @UniBasel_en !

[Journal of Cell Biology @JCellBiol]

Solinger et al. @Spang_Lab @biozentrum @UniBasel_en show that Arf1-GTP/GDP cycles drive adaptor complex–cargo interaction and release cycles, which are essential for cargo inclusion into Rab11 recycling vesicles at FERARI-mediated kiss-and-run sites. https://t.co/9HZLO1hrR4

[The Spang Lab @Spang_Lab]

How to determine the proteome of cellular compartments?
We established a method to do just that, published in @elife: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection https://t.co/eudW9kRIUi

[The Spang Lab @Spang_Lab]

Arf1 regulates TORC1 through two different ways! Great work by @EnklerLudovic and great collaboration with @MZavolan lab! #cell #biology #signaling
TORC1 spatial segregation and hysteresis are regulated by the small GTPase Arf1 https://t.co/Bt5Ti8fs4m

[FASEB @FASEBorg]

Switch on for the newest in Small GTPases at #SmallGTPSRC this June! Join @SpangAnne of @Spang_Lab alongside organizers Daniel Abankwa from @uni_lu, @ChristinBurd, @jcfromme, and Sabine Hilfiker from @Rutgers_NJMS. Register and submit your abstract by April 27: https://t.co/QpOKaHhwTC

[The Spang Lab @Spang_Lab]

What if you could cut out sub cellular structures and measure their proteome?
SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection https://t.co/UhrmrMM87X
awesome work by @CurdinF, @Alexia__F ,@Biehli & Alexander Schmidt

[The Spang Lab @Spang_Lab]

Check out our new paper on mRNA levels + P-body condensate properties. Congrats to Debdatto Mookherjee and @MadeleineRommel, super collaboration with @MariaHondele @FerdinandWeidn1 @MatejSiketanc
Non-translated mRNA levels determine P-body properties https://t.co/g5Wv5ZHZ8L

[The Spang Lab @Spang_Lab]

Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104 ! @biozentrum @UniBasel_en #cellbio
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites https://t.co/PYGsGXAGhX

[The Spang Lab @Spang_Lab]

Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites https://t.co/PYGsGXAGhX

[The Spang Lab @Spang_Lab]

Check out our newest finding on Arf1, the Jack of all trades: ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs https://t.co/PPYZIzqsCI
#endosome #recycling #cellbio

[The Spang Lab @Spang_Lab]

A little stress is good for you in #health #ageing ! #Diet is important! Take a look at our article with Emmanouil Kyriakakis as 1st author! @UniBasel_en @NatureComms @snsf_ch #Longevity #healthspan
https://t.co/kkR8Im2Sxx

[The Spang Lab @Spang_Lab]

wonderful collaboration with the @HillerLab . check it out!

[Biozentrum, University of Basel @biozentrum]

Proteins must be folded into their correct shapes to function properly. @HillerLab discovered tiny “folding factories” in cells that enable efficient and accurate protein folding. @UniBasel_en @snsf_ch @NatureCellBio
https://t.co/KU741oheOK

[The Spang Lab @Spang_Lab]

Congratulations Dr. Ott! newly minted #PhD from the @biozentrum @UniBasel_en

[ivanapetrovic @petrovic_iv]

I'm thankful to all our collaborators @Spang_Lab @samit2104, Anne Grahl, @LabStahlberg, Meltem Tatli and Dongchun Ni and my mentor, Stephan Grzesiek, who helped us bring this story to life.

[The Spang Lab @Spang_Lab]

Check out our latest paper! Congrats to Daniel Ott @Samit2104 and Jachen Solinger! well done! Coordination between ESCRT function and Rab conversion during endosome maturation | The EMBO Journal https://t.co/DvVTE7KuMG

[Biozentrum, University of Basel @biozentrum]

Congratulations to Anne Spang @Spang_Lab for receiving the renowned Lelio Orci Award. The award honors her pioneering work in intracellular organization and her research achievements in Cell Biology. @LS2Switzerland @UniBasel_en

https://t.co/cGTUIBNFBN

[The Spang Lab @Spang_Lab]

@AdrianoAguzzi Once you’re back on your bike and also work your other muscles again, your weight gain will be muscle mass ! Happy New Year!

[The Spang Lab @Spang_Lab]

@InTime_49 yes!

[The Spang Lab @Spang_Lab]

Wonderful meeting! Thank you for organizing and having me!

[Johannes Herrmann @Herrmann_lab]

The newly founded study group on Cellular Organelles of the German Society for Biochemistry and Molecular Biology @GBM_eV had its first symposium in Kaiserslautern. Exciting meeting with excellent talks and posters! So much fun! Next year, we organelle lovers meet in Düsseldorf!

[Journal of Cell Biology @JCellBiol]

From @Spang_Lab & @DrBakhtiar_S lab: LRBA gene mutations linked to severe childhood immune disorders involve Arf1-dependent pathways. These insights into endosomal traffic regulation may open doors to innovative treatments for LRBA deficiency https://t.co/Adc0Nr7WiF
#lysosome

[The Spang Lab @Spang_Lab]

The result of the wonderful collaboration with @DrBakhtiar_S lab is out! Great job @ViktriaSzentgy1 and Leon Lueck!
Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis https://t.co/cWGdNJ1rwc