Adrian Slaughter

Just here for the view

[Adrian Slaughter @SpotSlaughter]

Wondering if anyone out in the X-verse can help me decipher this artist signature? From a painting acquired on the Kings Rd, Chelsea in 1973. Family records suggest it was F.R. Lyon 1901 but it doesn’t look like this to me! Any help would be greatly appreciated!!

[Australian Government @ausgov]

On 11 Nov 1918, the guns of the Western Front fell silent – marking the end of the First World War after 4 long years.

[Adrian Slaughter @SpotSlaughter]

You gotta be a bot. It’s like arguing into a void. All my points remain. Never condoned, argued it’s abhorrent - simply suggested this stuffs far more prevalent than people like you believe. Going to blow up and lot more players and nations will be exposed. And yes, you do come across as a pious cunt - 2 x fave ausssie words for price of one!

[Adrian Slaughter @SpotSlaughter]

My point remains, if you’re arguing that it wasn’t prevalent then your naivety is only surpassed by your misplaced piety. Pile In now but you might be left with your pants down. Look up Fred Flintoffs comments post sandpaper gate… makes strong allusions to foreign materials being used for years and that it’s known and talked about widely in cricket circles. This whole saga has more to come and when it blows, it won’t just be the Aussies in the spotlight.

[Adrian Slaughter @SpotSlaughter]

@hjheathy @BreadBagsMcChav I’ll dumb it down for you Dexter, it was cheating but if you think they’re alone in doing so and that tampering wasn’t widespread then I’ve got a bridge to sell you…

[Adrian Slaughter @SpotSlaughter]

@Tigermask1337 @BreadBagsMcChav Incomprehensible gibberish… comically stupid

[Adrian Slaughter @SpotSlaughter]

@Tigermask1337 @BreadBagsMcChav Not defending it but definitely pointing out that pious (and your racist garb) is both Farkin onerous and likely built on sand… sub continental teams basically invented reverse swing. Make of that what you will fuckwit

[Adrian Slaughter @SpotSlaughter]

@hjheathy @BreadBagsMcChav This post will age like milk. Who knows who was using what. I’d suggest your sanctimonious piety in this is tedious and going to bite you in the ass…

[Adrian Slaughter @SpotSlaughter]

@alc2022 HIMS

[Adrian Slaughter @SpotSlaughter]

@TheKouk Despite the budget you mean. Being industrial heavy and full of high div defensive stocks has helped in light of a tech rotation in the US. ASX is in for a static low growth future… no innovation means mediocrity.

[Adrian Slaughter @SpotSlaughter]

@jimcramer Because they’re not day trading?!? It’s a long term asymmetric bet that GOOG benefits exponentially in the long term. Agree or disagree but that appears the metric. An outlook many should adopt…

[Adrian Slaughter @SpotSlaughter]

@pedrojr_90 Oh fark off, then fark off some more. You leftard naarmgroids shit me to tears. Your state has viscerally been destroyed by Andrews, Allen & Co and yet you still year for more. Stockholm syndrome or stupidity… me thinks the latter.

[Adrian Slaughter @SpotSlaughter]

@BarbaraPocock My lord, I've seen plenty of moronic takes on twitter / X but this takes the cake. We have a productivity problem... over taxing the private sector whom are the only fiscal payee to the bloated public sector is moronic beyond words. Get a lobotomy fool...

[Adrian Slaughter @SpotSlaughter]

@_SatyaPrakash08 Michael Bevan is first name picked...

[Adrian Slaughter @SpotSlaughter]

Grok bot is awesome! I've investigated an idea, stress tested its merits, built a website, registered the websites & business name - all within a few hours and all at significantly less cost than I would have done pre grok bot by some margin, 1000's actually... what a boon for small business!

[Adrian Slaughter @SpotSlaughter]

I love this country and normally would applaud optimism, however I share none of your positivity. Australia was for most of my adult life known, at least in financial and economic circles as the ‘wonder down under’. Its demise into an unproductive and simple service led economy with bloated civil service, strangled private sector and ballooning debt leaves me forlorn… to appreciate its demise means you’ve seen the highs and we are not a shadow of the prosperous, harmonious and innovative country we once were. This fills me with no joy to express…

[Adrian Slaughter @SpotSlaughter]

@xybmisekxop9we https://t.co/pv2XTcAfgw

[Antonio Linares @alc2022]

I believe $NAUT is worth several billion today, because it's on a path to enable us to cure deadly diseases like Alzheimer's with a single prompt by 2027-2028.

The breakthrough is not better protein measurement.

It is reading the state machine of human biology.

In Nautilus' tau paper, they found that phosphorylation is not random.

pT181 makes pT217 about 8x more likely to appear on the same intact tau molecule.

That matters because adding PO4 groups changes tau's charge distribution, which changes its conformation, which changes how tau binds microtubules.

Microtubules are the rails neurons use to move mitochondria, vesicles and proteins over enormous distances.

Tau helps stabilize those rails.

Change tau's molecular configuration enough and:

tau detaches → microtubules destabilize → transport breaks → neurons degenerate

Alzheimer's may therefore not be "too much phosphorylated tau."

It may be a progression through specific molecular states:

tau A → pT181 → pT217 → additional PTMs → pathological proteoform

And until now we largely could not read that combinatorial layer cleanly.

Mass spectrometry measures mass and charge extremely well, but two intact tau molecules can have the same mass while carrying the same phosphate at different positions.

Same atoms.
Same mass.
Very different biological behavior.

Fragmentation can help, but reconstructing the exact PTM configuration of millions of intact molecules becomes difficult.

Nautilus instead repeatedly interrogates the same intact protein with different probes.

Its tau assay currently reads isoform plus 7 phosphorylation sites, creating hundreds of potential molecular states, while reporting about 5.5% end to end CV versus about 25% cited by management as an industry benchmark.

And here is where this gets insane.

Biology does not appear to occupy every theoretically possible state.

Of 768 tau proteoforms their assay could resolve, they observed only 130 across all samples, and far fewer within individual biological systems.

That means the real state space may be highly constrained.

Now collect enough longitudinal data:

initial proteomic state + treatment → final proteomic state

Do that across millions of patients and interventions and AI stops being merely descriptive.

It becomes predictive.
Given molecular state X, what intervention moves the system toward healthy state Y?

That is effectively a biological key:lock search problem.

For tau alone, that could mean finding the intervention that prevents the proteoform trajectory that causes tau to abandon and damage the neuronal microtubule system.

But tau is just one vertical assay.

Add alpha synuclein.
Amyloid beta.
Cancer proteins.
Immune proteins.
Metabolic proteins.

Thousands more.

Eventually:

genome + proteoform state + treatment history → full body molecular state transition model

A genuine digital twin of human biology.

The endgame is not simply detecting disease earlier.
It is asking:

given this person's current molecular state, what intervention moves them back toward the healthy state?

And having an AI trained on billions of measured biological transitions produce the answer.

That is why I think $NAUT is building something much larger than a proteomics machine.

It is building the data layer required for AI to learn how to steer human biology.

[Adrian Slaughter @SpotSlaughter]

@codenrl now wait til next years RWC and do a like for like comparison. It's possible to enjoy both codes - being a Wallaby and Kangaroo fan is not mutually exclusive / binary scenario. RWC will blow the RLWC out of the water...

[Adrian Slaughter @SpotSlaughter]

@australian Chalmers is abysmally stupid and frighteningly inept...