Stem Cell Tracker

Stem Cells. Genetics. Longevity.
Tracking the research as it happens.
Share ≠ Endorsement. Not medical advice.

[Stem Cell Tracker @StemCellTracker]

This week in stem cells 🧫
○ A phase 3 trial in Japan used synovial stem cells (from joint lining tissue) to repair torn knee meniscus, with knee scores up 53.5 points at 1 year.

○ Wake Forest reported donor placental stem cells closed chronic diabetic foot ulcers in all 10 patients within 6 months.

○ Johns Hopkins scientists studied skin fibroblasts from the soles of the feet to learn why that skin is so tough.

[Stem Cell Tracker @StemCellTracker]

@Plasmaartresto Yes, same product!

[Stem Cell Tracker @StemCellTracker]

Japan phase 3 trial: surgeons stitched hard to repair meniscus flap tears and added patients' own synovial stem cells (from the knee lining). Knee function scores rose 53.5 points at 1 year, beating a 22 point target. Single arm, no control group yet.
https://t.co/M3hasHdmDH

[Stem Cell Tracker @StemCellTracker]

Source: Placental stem cell therapy shows promise for diabetic foot ulcers
https://t.co/41zr7o6PvD

[Stem Cell Tracker @StemCellTracker]

Donor placental stem cells closed chronic diabetic foot ulcers in all 10 patients within 6 months in a first human study. 9 of 10 regained protective foot sensation by 12 months.

[Stem Cell Tracker @StemCellTracker]

The FDA gave nulacel, Kamau's sickle cell gene therapy, RMAT designation (faster FDA support for regenerative medicines). In its early trial, all 3 patients on the newer process stopped needing transfusions and had no pain crises. Not an approval yet.
https://t.co/fFTCTymvpt

[Stem Cell Tracker @StemCellTracker]

Scientists grew realistic mini human lenses from stem cells for the first time. The iPSC organoids (tiny 3D tissues) have the proteins that keep lenses clear and organized fiber cells. A new way to study cataracts, which affect about 94 million people.
https://t.co/IeR9HYr5rz

[Stem Cell Tracker @StemCellTracker]

One knee injection of OSCA (osiramestrocel, a stem cell therapy with a cartilage matrix) cut osteoarthritis pain about 61% at 6 months vs 23% on placebo in a 113 patient phase 2a trial. No treatment related serious side effects.
https://t.co/pQjr2vIvD6

[Stem Cell Tracker @StemCellTracker]

Explore the full timeline: https://t.co/KgjIgSwIOl

[Stem Cell Tracker @StemCellTracker]

On this day in 1958, physicist Radojko Maksić received bone marrow from a stranger, French volunteer Marcel Pabion. It was the first marrow graft from an unrelated donor, and Maksić survived. #StemCellHistory #OnThisDay

[Stem Cell Tracker @StemCellTracker]

Takeda joined the ISSCR consortium building shared standards for stem cell models used in drug testing, alongside Bayer and Novo Nordisk. The goal is lab grown human tissues that flag unsafe drugs before trials and reduce animal testing. https://t.co/5XLP8W4nXS $TAK

[Stem Cell Tracker @StemCellTracker]

German researchers slowly turned back the clock on human blood cells, including some from a 101 year old donor. In under two months of partial reprogramming, one DNA aging marker reversed by up to 60 years, without turning the cells into full stem cells. https://t.co/DfyDJygdGB

[Stem Cell Tracker @StemCellTracker]

Source: Experimental cell therapy improves skin resilience, advancing treatments for skin injuries https://t.co/RA3M294s62

[Daniel Hale @DanielH03274759]

Colorado24yr. ALS Research can now show 90%+ ALS recovery in 6-12 months using stem cell support while enabling these cells to be effective in everyone. Recovery must come from the least amount of profit made by showing how mammals trigger the ALS biophysics event. Decades ahead

[Stem Cell Tracker @StemCellTracker]

Beam Therapeutics' base edited stem cell therapy for sickle cell disease met its main goal in the BEACON trial: no severe pain crises for at least 12 straight months. 49 patients treated so far. Beam aims to file with the FDA as early as year end. $BEAM https://t.co/uGXJuiPAjy

[Stem Cell Tracker @StemCellTracker]

USC Stem Cell won a $6.9 million CIRM grant to finish preclinical work on a heart muscle therapy made from stem cells. The goal is a first human safety trial in late 2027 for people with severe heart attacks (cardiogenic shock), at USC and UW.
https://t.co/25w6m4qEvl

[Stem Cell Tracker @StemCellTracker]

@martinperaJAX Lineage tracing follows cells to see what they become. This study found cells in mouse embryos and embryo models narrow their fates at different times.

[Stem Cell Tracker @StemCellTracker]

@ACRheum This abstract reports that CD19 CAR T therapy improved outcomes and lowered fibrosis (scarring) gene activity in the skin of people with dcSSc.

[Stem Cell Tracker @StemCellTracker]

@smbenlazar This trial tested a ready made megakaryocyte product. Megakaryocytes make platelets, and these patients had low platelets after a stem cell transplant.

[Stem Cell Tracker @StemCellTracker]

@CRISPRTX @American_Heart CTX310 edits the ANGPTL3 gene inside the body. That gene helps control blood fats, and this Phase 1b study looked at people with very high triglycerides.