Stephen Brennan

MB BCh, MRCPI, MSc @UniOfGalway

[Stroke Clinical Trials Network Ireland (SCTNI) @SCTNIreland]

Thank you for a magnificent conference @ESOstroke #esoc2026 #voiceofstroke Congratulations to all our fellows on their scientific contributions @StephenBr_

[Stroke Clinical Trials Network Ireland (SCTNI) @SCTNIreland]

Check out our new pre-print on TNF signalling in atherosclerosis and stroke ! Data to be presented @ESOstroke #stroke #inflammation #esoc2026 in Omics session on Wednesday evening !

https://t.co/aSCR72kgEE

[Johanna Ospel, MD PhD @johanna_ospel]

At https://t.co/td1yiUkEe8, we sat together and thought about what needs to be done to advance #multidisciplinary #stroke #biomarker research in a pragmatic and meaningful way. This @TheLancetNeuro paper summarizes what we came up with. https://t.co/KYf60ZJeld

[Stroke Clinical Trials Network Ireland (SCTNI) @SCTNIreland]

Congrats to Stephen Brennan #STROKE Simultaneous publication at #WSC2025

Why we need trials for patient-focused questions @StrokeAHA_ASA

"Quality of Evidence in European Stroke Organisation and American Heart Association Stroke Guidelines" https://t.co/cXSAeusEbQ

[Stroke AHA/ASA @StrokeAHA_ASA]

2/ Only 14% (@AHAScience) and 7% (@ESOstroke) of recommendations are supported by high-level evidence. Most rely on observational data or expert opinion.

https://t.co/vg2NgAaYbE

#AHAJournals @mihill68 @Diana_A_Sousa @SCTNIreland @SCouttsMD @bijoymenon

[Stroke Clinical Trials Network Ireland (SCTNI) @SCTNIreland]

Does anticoagulation reduce stroke recurrence in patients with sub clinical AF? Check out our editorial & recent paper by Palaiodimou et al https://t.co/J105SzCMBf @ESOstroke @UCD_Research #stroke #stroketwitter

[Stephen Brennan @StephenBr_]

A huge thanks to my co-author @AlexTinworth

Let me know if you have any thoughts or questions!

[Stephen Brennan @StephenBr_]

Our findings suggest that while PDE5A inhibition may benefit cerebrovascular health, the genetic evidence does not support the idea that these drugs protect against Alzheimer’s disease.

[Stroke Clinical Trials Network Ireland (SCTNI) @SCTNIreland]

We are really thrilled to share our recent data published today @CircAHA. IL-18 appears to be a promising target for the prevention of cardio-embolic stroke & heart failure! Congrats to @StephenBr_ #stroke #atrialfibrillation @UCD_Research @CamStroke @MariosGeorgakis

[Marios Georgakis @MariosGeorgakis]

Drug target Mendelian randomization for IL-18 downregulation🎯🧬
⬇️risk for adverse cardiac remodelling, heart failure, cardiomyopathy, AFib, cardioembolism
⬇️risk of CKD and T2D
⬇️risk of atopic and autoimmune diseases
⬆️risk of lung cancer, multiple sclerosis, infections

[Stroke Clinical Trials Network Ireland (SCTNI) @SCTNIreland]

Ever wonder what drives recurrent stroke in our patients with AF? Check out our new paper in Neurology!

@ronancollins7 @TCDGerontology @foley_m1 @UCDMedicine @UCD_Research @GreenJournal #stroke #atrialfibrillation

https://t.co/YIZzoO6STM

[Veera Rajagopal  @doctorveera]

Association of BMI polygenic score with diseases with and without adjusting for BMI. Interesting work from deCODE Genetics.

I bet most of these indications are currently being studied in GLP1 clinical trials.

Einarsson et al. Nat Comm
https://t.co/QPSQ4tumSK

[Stroke Clinical Trials Network Ireland (SCTNI) @SCTNIreland]

Congratulations to Dr. Stephen Brennan on a brilliant talk on Mendelian randomisation data demonstrating that IL-18 is implicated in a high risk:
-Heart failure
-AF
-Cardioembolic stroke
-cardiac remodelling

@ESOstroke @MaterStroke @UCD_Research @MaterDublin #esoc #stroke

[Stephen Brennan @StephenBr_]

Left ventricular pseudoaneurysm: an inadvertent consequence of COVID-19—a case report https://t.co/bqLHwtHklr

[Stephen Brennan @StephenBr_]

@foodborn @EmmaQuinlan https://t.co/xVExBnBFXk

[Stephen Brennan @StephenBr_]

@paul_finn @GeorgeLeeRTE @mcculld It’s very likely that some more deaths will be added. In Ireland, providers have three months to notify coroners that a death has occurred, this is the notified death that the CMO reports on each day.

[Stephen Brennan @StephenBr_]

@boldteddy @Daithipower81 @EwanMacKenna @GeorgeLeeRTE The best way/only way really to know in the short term is by icu admissions and by how much the health system is overwhelmed. The majority of deaths are reported in a week, so looking back at previous weeks death rates is good way to see how things are trending.