SRC Lab

Protein Homeostasis & Proteomics Lab headed by Dr. Swasti Raychaudhuri

Account managed by Lab members

[Cell Reports @CellReports]

DDX39A unwinds viral RNA G-quadruplexes to limit α-Synuclein amyloidogenesis https://t.co/tW0F8VlSer

[The Science of Parkinson's @ScienceofPD]

Interesting: @SwastiLab reports that mRNA G-quadruplexes-dependent interactions with the DEAD-box helicase DDX39A decelerates α-Synuclein amyloidogenesis. Interupting interactions between α-Syn & DDX39A⬆️amyloidogenesis, while over-expressing DDX39A⬇️it
https://t.co/DCUQz5HawZ

[SRC Lab @SwastiLab]

Is viral infections a ticking clock for Parkinson's disease?
Our lab shows that Viral RNA can fuel α-Synuclein amyloidogenesis -but DDX39A fights back by unwinding the RNA G-quadruplexes. Kudos to
@Aanchal77521343 and @rcswasti
https://t.co/Z96eFyoibY
@ccmb_csir @AcSIR_India

[SRC Lab @SwastiLab]

Huge congratulations to @Guptapooja_28 on being awarded her doctorate! 🎓🎉

[SRC Lab @SwastiLab]

Dr. Amitabha Majumdar ends the session with his findings uncovering a mechanistic link between condensates, transcriptional regulation, development, and disease. #EMBOCCMB25 @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

Prof. Dr. Manish Jaiswal uncovering how a developmentally programmed mechanism links membrane tubulation, fission & fusion to mitochondrial remodeling — showing how dynamic organelle architecture is coupled to cell fate. #EMBOCCMB25 @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

@prasad_kasturi kickstarts the last day of the conference explaining how HSP‑16s are crucial under mild stress—linking PQC, phase-separation condensates and stress-granule biology to aging resilience and lifespan extension

[SRC Lab @SwastiLab]

Solving mystery: Dr. Dhanasekaran
Shanmugam is sharing insight into how Toxoplasma gondii exploits metabolic flexibility to survive the loss of its entire apicoplast, revealing crucial vulnerabilities for anti-parasitic drug development! #EMBOCCMB25 @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

BIG IDEAS ALERT-The parasite's PQC machinery is fundamentally different from ours! Dr. Niti Kumar shows how these diverged components are key to maintain homeostasis under stress and are now prime targets for drug development to minimize resistance. #EMBOCCMB25 @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

FEEL THE EXCITEMENT: @kausikigib reveals a surprising link in S. cerevisiae: loss of mtDNA activates a cryptic interorganellar cooperation to combat proteotoxicity. This mechanism enhances protein quality control degradation! #EMBOCCMB25 @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

Tune in! @omc111 is demonstrating how liquid-liquid phase separation (LLPS) creates specialized organelles required for efficient CO₂ fixation. Understanding this spatial compartmentalization is guiding efforts to engineer higher-performing crops! #EMBOCCMB25 @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

HIGH-RES DISCOVERY: Prof. Dr. Markus Schwarzländer shows how biosensor-based live imaging is uncovering the unique way plant organelles act as mobile response entities, underpinning the metabolic flexibility of the chloroplast/mitochondria axis! #EMBOCCMB25 @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

Happening now! @Santosh_CCMB is discussing his recent findings on Initial events of inhibitory signaling in human natural killer cells! at #EMBOCCMB25 @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

INSIGHTS FLOWING: The dynamic interactions between biomolecular condensates and membranes—a crucial defense mechanism—are now being revealed by @claudiobussi at #EMBOCCMB25 @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

Grab a seat! Listen to @MahakSharma23 appreciating the role of small G protein Arl8b in lysosome biogenesis and highlighting its necessity for the proper function of the endosomal retrieval system at #EMBOCCMB25 @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

@AnishaSumith student of @Ishwariya13 Lab, with her creation "Synaptic Symphony" #sciart #EMBOCCMB25

[SRC Lab @SwastiLab]

Starting #EMBOCCMB25 Day4 with Prof. Dr. Janine Kirstein presenting her work on regulation of amyloid proteins of Huntintington's diseases and an active chaperone complex formation that surprisingly changes HTT fibril structure, driving secondary nucleation. @EMBO @ccmb_csir

[SRC Lab @SwastiLab]

@ccmb_csir has a long standing tradition of intergrating science and art. This is a special day of the conference, with a cultural program showcasing @SPKSitar at #EMBOCCMB25 @EMBO

[SRC Lab @SwastiLab]

A flash talk being delivered by our lab member @Aanchal77521343 at #EMBOCCMB25 @csir_ccmb @EMBO

[SRC Lab @SwastiLab]

Get ready to dive into mitochondrial dynamics! Our speaker @Oishee_Chak is here at #EMBOCCMB25 to reveal the molecular mechanism preventing destructive hyperfusion, focusing on the critical role of the endoplasmic reticulum. @EMBO @ccmb_csir