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SynBioBeta 2027 Super Early Bird pricing is available through Friday, June 15. Join the AIxBio founders, biopharma leaders, investors, and startups building the future of biology. Presenting sponsor: Pumpkinseed May 3–6, 2027 | San Jose, CA Lock in your pass early. https://t.co/oDyS6XJ0Q4

SynBioBeta's tweet photo. SynBioBeta 2027 Super Early Bird pricing is available through Friday, June 15.

Join the AIxBio founders, biopharma leaders, investors, and startups building the future of biology.

Presenting sponsor: Pumpkinseed

May 3–6, 2027 | San Jose, CA
Lock in your pass early.

https://t.co/oDyS6XJ0Q4

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Aaron Blotnick

@AaronBlotnick

sekitar 4 jam yang lalu

🚨 Exclusive: Saku Biosciences and Sable Fermentation, Inc. have signed an exclusive US strategic alliance agreement, putting strain engineering and scale-up under one contract. @SynBioBeta has the story:👇 Most microbial products pass through four stages on the way to market: 1. Strain development: engineering and screening a microbe for titer, rate and yield. 2. Upstream processing: fermentation development and scale-up. 3. Downstream processing: recovery, separation, concentration and drying. 4. Formulation: turning the material into something a customer can apply or ship. Different vendors usually handle these stages, and each handoff means a new MSA and a new tech transfer. The costliest gap is between stages 1 and 2. Strains are usually screened in well plates or shake flasks, where oxygen transfer, mixing and substrate feeding look nothing like a stirred-tank bioreactor. The best performer on the bench is often not the best performer in the tank, and that mismatch shows up months later at pilot scale. Saku (strain development) Saku's PicoShells, developed in @dinodicarlo lab at @UCLA and published in PNAS, are picoliter-scale hydrogel particles with a porous shell. Each one holds a single cell and its descendants, fenced in but exposed to the surrounding media. That means more than a million clonal colonies can grow together in real production conditions and be sorted on standard equipment, up to 10 million in a day. Mark van Zee and John Alden picked Sable specifically because they knew what was missing was the scale up peice. Sable (upstream, downstream and formulation) Sable's Wake Forest, NC pilot plant runs submerged fermentation from 1L to 200L, with downstream processing including tangential flow filtration, centrifugation and spray drying, plus formulation and analytics. Its team comes largely from ag biologicals, including AgBiome, Marrone BioInnovations and Pasteuria Bioscience, Inc. Put together, Saku selects strains in the kind of environment Sable will run them in, and the results from Sable's runs go straight back into the next round of screening. "We saw an opportunity to solve one of the biggest inefficiencies in bioprocess development: the disconnect between strain selection and the conditions a strain will ultimately face at scale," said Toni Bucci, Ph.D., founder and CEO of Sable Fermentation. Sable manages the customer relationship end to end. Neither company takes back-end royalties or claims on customer IP. They are paid through success fees. The arrangement is aimed at food, agriculture and industrial biotech companies moving from lab scale toward contract manufacturing.

AaronBlotnick's tweet photo. 🚨 Exclusive: Saku Biosciences and Sable Fermentation, Inc. have signed an exclusive US strategic alliance agreement, putting strain engineering and scale-up under one contract. @SynBioBeta has the story:👇

Most microbial products pass through four stages on the way to market:

1. Strain development: engineering and screening a microbe for titer, rate and yield.
2. Upstream processing: fermentation development and scale-up.
3. Downstream processing: recovery, separation, concentration and drying.
4. Formulation: turning the material into something a customer can apply or ship.

Different vendors usually handle these stages, and each handoff means a new MSA and a new tech transfer.

The costliest gap is between stages 1 and 2. Strains are usually screened in well plates or shake flasks, where oxygen transfer, mixing and substrate feeding look nothing like a stirred-tank bioreactor. The best performer on the bench is often not the best performer in the tank, and that mismatch shows up months later at pilot scale.

Saku (strain development)
Saku's PicoShells, developed in @dinodicarlo lab at @UCLA and published in PNAS, are picoliter-scale hydrogel particles with a porous shell. Each one holds a single cell and its descendants, fenced in but exposed to the surrounding media. That means more than a million clonal colonies can grow together in real production conditions and be sorted on standard equipment, up to 10 million in a day. Mark van Zee and John Alden picked Sable specifically because they knew what was missing was the scale up peice.

Sable (upstream, downstream and formulation)
Sable's Wake Forest, NC pilot plant runs submerged fermentation from 1L to 200L, with downstream processing including tangential flow filtration, centrifugation and spray drying, plus formulation and analytics. Its team comes largely from ag biologicals, including AgBiome, Marrone BioInnovations and Pasteuria Bioscience, Inc.

Put together, Saku selects strains in the kind of environment Sable will run them in, and the results from Sable's runs go straight back into the next round of screening.

"We saw an opportunity to solve one of the biggest inefficiencies in bioprocess development: the disconnect between strain selection and the conditions a strain will ultimately face at scale," said Toni Bucci, Ph.D., founder and CEO of Sable Fermentation.

Sable manages the customer relationship end to end. Neither company takes back-end royalties or claims on customer IP. They are paid through success fees.

The arrangement is aimed at food, agriculture and industrial biotech companies moving from lab scale toward contract manufacturing.

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