T2Diabetesgenes

A team of research scientists trying to unlock the secrets of your DNA. Type 2 diabetes, growth, menopause, and related human traits.

[T2Diabetesgenes @T2Diabetesgenes]

@rnbeaumont1 @YaghootkarH @marcustuke @kate_s_ruth @AnnaM1966 @rmfreathy @drarwood @timfrayling @ExeterMed @uk_biobank @DNAFitHQ The allele associated with eating yeast extract was present in 73% of consumers and 71% of non-consumers. This variant and those previously reported to influence marmite preference have little predictive value for yeast extract consumption.

[T2Diabetesgenes @T2Diabetesgenes]

@rnbeaumont1 @YaghootkarH @marcustuke @kate_s_ruth @AnnaM1966 @rmfreathy @drarwood @timfrayling @ExeterMed @uk_biobank @DNAFitHQ We identified 1 locus (rs62099778) associated with yeast extract consumption (p=2E-8; OR 1.06). The yeast extract consumption allele was also associated with higher salt consumption (p=3E-17), & vegetable intake (P=3E-6), lower caffeine intake & higher risk of depression (P<5e-5)

[T2Diabetesgenes @T2Diabetesgenes]

@rnbeaumont1 @YaghootkarH @marcustuke @kate_s_ruth @AnnaM1966 @rmfreathy @drarwood @timfrayling @ExeterMed Using 135730 @UK_Biobank participants we performed a GWAS of self report yeast extract consumption (data field 20088) (15315 consumers/120415 nonconsumers). Variants previously associated with loving or hating marmite in 261 people had P>0.02 https://t.co/0RbzqpwJiH @DNAFitHQ

[T2Diabetesgenes @T2Diabetesgenes]

Christmas special publication.
A GWAS of yeast extract consumption #marmitegenes
By
@rnbeaumont1 , SE Jones, @YaghootkarH, @marcustuke @kate_s_ruth , F Casanova, S Sharp, Y Ji, W Thompson, JHarrison, @AnnaM1966 @rmfreathy, J Tyrrell, @drarwood , @timfrayling
Address @ExeterMed

[Craig Beall_Lab🏴󠁧󠁢󠁳󠁣󠁴󠁿 @Craig_Beall]

Well done to @axonology and team @ExeterMed for inspiring young people to think about careers in #science @BBCSpotlight https://t.co/09ApXpH5sh

[T2Diabetesgenes @T2Diabetesgenes]

More on LDL & other lipids versus T2Diabetes risk from us, @FallTove & @ErikIngelsson : https://t.co/UN0xGu3JOk

[T2Diabetesgenes @T2Diabetesgenes]

Genetics informing if & how low LDL-C increases T2Diabetes risk: https://t.co/Rh0HlLWnde & https://t.co/9iigfs3MkU & https://t.co/UN0xGu3JOk

[T2Diabetesgenes @T2Diabetesgenes]

G x E. More from us on the thorny problem of gene x obesogenic lifestyle & environment interactions: https://t.co/wEnAblRvOW

[T2Diabetesgenes @T2Diabetesgenes]

As your GWAS study hits 100,000s, take care: https://t.co/68FUzPTSw2 from @zkutalik & @YaghootkarH

[bioRxiv Genetics @biorxiv_genetic]

Heterozygous RFX6 protein truncating variants cause Maturity-Onset Diabetes of the Young ... https://t.co/dLQk6q9nx5 #biorxiv_genetic

[Prof M Ala-Korpela @mak_sysepi]

Comment by @paulwfranks Eloquent analyses, validation & interpretation of gene-lifestyle interactions in @uk_biobank https://t.co/Ev6yk5dQuD

[Richard Sever @cshperspectives]

Can’t say it enough: if you’re frantically submitting to a journal before the holidays, consider how likely YOU'd be to referee by Jan 2... https://t.co/ouIu9mLvUX

[euan ashley @euanashley]

Broken link. Sorry! Here's the right one: https://t.co/0HODfIWEXN

[euan ashley @euanashley]

New from us today. Long-read whole genome sequencing identifies causal structural variation in a Mendelian disease https://t.co/QCutFyp7yn…

[Clive G. Brown @The__Taybor]

Also forgot to mention wen I get my genome from 1 promethion cell that's a < $1000 genome. No wait, no amortisation no, capital.

[T2Diabetesgenes @T2Diabetesgenes]

Links to all our publications here, including latest on sleep genetics from @mnweedon & Sam Jones in @PLOSGenetics : https://t.co/uBSMgqszlV

[T2Diabetesgenes @T2Diabetesgenes]

Maths, physics or comp science BSc with interest in biomedicine? Then please consider MRC PhD studentship in SW: https://t.co/PWOw5WIQJ5.

[Mark McCarthy @markmccarthyoxf]

Our paper showing links bw birthweight & lateonset disease only poss bc of @uk_biobank. @rmfreathy & I explain why:
https://t.co/3qBYlPoEfr

[Karol Estrada @karls_es]

Results from our Phase I RCT on Alzheimer's Disease have been published today @nature https://t.co/EilUsVucTQ

[Exeter Med School @ExeterMed]

Exeter diabetes research on @BBCRadio4 'Personalised medicine: Dose by design', tomorrow 8pm https://t.co/DhR6gh61jP