Translational Nuclear Receptor Research Lab

Hi there!
We are the Translational Nuclear Receptor Research unit, led by Prof. Karolien De Bosscher. You can find us in the beautiful city of Ghent (Belgium).

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

🎉 Congratulations to Milton Antwi (@miltzz3) for winning a prestigious poster prize at the 2023 International Liver Congress (#EASLcongress) organized by @EASLnews in Vienna, Austria! 🌍🏆@ugent @ugent_fge @uzgent @VIB_CMB

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

We went to primary schools to teach about DNA & the heredity of genes for 'Science on the Road'. Children built candy DNA and performed an experiment to find out: Is it you, or your DNA that you (dis)like coriander?
We hope we have inspired some of them to become scientists!

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

Interview by our @TNRR_Lab team members Milton Antwi and @NickDeploey !

[VIB @VIBLifeSciences]

🙌 Meet Katleen De Preter (@kdpreter) who recently joined @VIB_CMB as principal investigator. Milton Antwi and @NickDeploey interviewed her for us. Kalteen's TOBI team develops analytical and bioinformatic pipelines for more precise cancer management. 👇
https://t.co/JDvOO5F0zv

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

Last month, Eleni Staessens won the Ziphius-award for her master thesis around the use of HDAC6 inhibitors in Multiple Myeloma. This month, Eleni started her PhD in our @TNRR_Lab. Congrats and welcome (back) Eleni!

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

TNRR Team dinner after a day of scientific retreat 🤤

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

The limited predictive power of cell-based screening assays hampers the search for better glucocorticoids. In this latest research, we developed novel luciferase-based assays that are consistently better predictors for GC signaling on the endogenous level.
https://t.co/teEtlzsdKn

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

Congrats to our latest lab member Lisa Koorneef for obtaining the @FWOVlaanderen Junior Postdoc grant on battling Rheumatoid Arthritis with Nuclear Receptor Heterodimers. Good luck finding the best of both worlds!

[Kris Gevaert @KrisGevaert_VIB]

New work of Laura of @TNRR_Lab and my lab: "Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets" https://t.co/Vc0XM6sb6J with @Svennetti @AnStaes and many more!

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

Striving to improve treatment responses and quality of life of multiple myeloma patients by studying nuclear receptor crosstalk (Dorien Clarisse, @TNRR_Lab) #whywecare #dagtegenkanker

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

Our myeloma team participated to the Wear Red Day of @metoyoufonds .Let's raise awareness for blood cancer! #samensterk #stichtingmetoyou
#fightbloodcancer #WearRedDay @crighent

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

In the latest Nature Communications, Dorien Clarisse and Karolien De Bosscher, discuss the contribution of the Glucocorticoid Receptor in therapy resistance in the treatment of solid cancers.
https://t.co/QPjb0YfMv2

[VIB Medical Biotechnology @VIB_CMB]

CMB is op zoek naar een enthousiaste (bio-)IT'er ter ondersteuning van onze IT-systemen.
https://t.co/oqxZ65q89e

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

Welcoming another talented PhD student to the team! Milton Antwi recently obtained his @FWOVlaanderen grant to study PPARα-ERRα ligand combinations in treatment of non-alcoholic fatty liver disease. 🤞🤞 for a Covid-free 2021 to celebrate this with the team!

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

@KrisGevaert_VIB @VIB_CMB Talented PhD student found! Chloé Van Leene started this month on her PhD project titled: "A new tool to map proteome conformations in cells to reveal the structural plasticity of the glucocorticoid receptor". Welcome and good luck, Chloé!

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

Check out the latest review of Dorien Clarisse (Postdoc @TNRR_Lab
) in BBA-Reviews on Cancer. We discuss the need to reevaluate the use of glucocorticoids in lymphoid malignancies and how a deep understanding of glucocorticoid responsiveness is required. https://t.co/lQhdxRlP5b

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

New perspective paper by our PhD student Laura about the quest for improved Glucocorticoid Receptor Ligands! https://t.co/cKsjyzlt8P

[Kris Gevaert @KrisGevaert_VIB]

Please help spreading! The @VIB_CMB De Bosscher lab and my lab are hiring a talented PhD student who fearlessly will take on the challenge of using conformational proteomics to study the glucorticoid receptor. More info: https://t.co/lp8ABAN80k.

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

Take a look at our latest review on nuclear receptor crosstalk in Nature Reviews Endocrinology. Glad to have collaborated with Eva Estébanez-Perpiñá & Luc Brunsveld!
@NatureRevEndo @Eva46653369

[Nature Reviews Endocrinology @NatureRevEndo]

New content online! Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation https://t.co/TEfpJ3rfKC

[Translational Nuclear Receptor Research Lab @TNRR_Lab]

We are recruiting a new PhD student!
Do you want to help us find novel therapeutic strategies to treat non-alcoholic fatty liver disease?
Then this might be the perfect opportunity for you!

More info:
https://t.co/GxWFOAMhbS

[Nick Deploey @NickDeploey]

So happy to receive an @FWOVlaanderen grant!

I will be joining @TNRR_Lab with my research focusing on the glucocorticoid receptor.