Perry

[Massimo @Rainmaker1973]

The mesmerizing voice of Ekaterina Shelehova, in her experimental singing sessions.

[Hans Amato @HansAmato]

There is one mechanism that ages you faster than almost anything else.

Not sugar. Not seed oils. Not stress alone.

Endotoxin.

When gram-negative bacteria in your gut shed LPS into a leaky gut barrier, it enters your bloodstream and activates TLR4 receptors on immune cells throughout your body.

What that cascade produces:

Thyroid dysfunction. Testosterone suppression. Insulin resistance. Mitochondrial dysfunction. Systemic fibrosis, the slow replacement of healthy tissue with scar tissue. Brain inflammation. Liver overload. Cardiovascular risk. Metabolic syndrome. Alzheimer's progression.

The research uses the phrase "metabolic endotoxemia", a low-grade but chronic inflammatory state driven by gut-origin LPS that drives rapid aging across every system simultaneously.

You can be doing everything right and still have elevated endotoxin.

The diet, the training, the sleep... all correct.
The gut barrier, compromised.

That gap is where most modern health failures live.

[Jack @jack_schroder_]

Lowering/balancing gut serotonin and kynurenine pathway metabolites helps resolve both gut and systemic inflammation.

IBD patients have significantly lower serum tryptophan levels than controls, meaning it's more than likely making an excess of the above.

You don't have to avoid L-tryptophan, you can simply modulate what pathways it goes down:

Inhibit TPH1:
- Vitamin D (via sunlight)
- Lignans (flaxseeds)

Inhibit IDO1:
- Pau D'Arco
- Ginseng
- Anthraquinones (aloe vera, rhubarb, senna leaf)
- Sophora flavescens
- CoQ10
- Black seed oil
- Niacin/NAD+

All quinones will also indirectly shift tryptophan away from kynurenine pathway because they increase NAD+ via NQO1 enzyme. NRF2 increases NQO1 so polyphenol-rich plant foods are highly beneficial here, alongside AMPK increasing NRF2, thus NQO1, so anything that raises it is also highly beneficial (eg., fasting, exercise, cold exposure, infrared light, Ginseng, Jiaogulan).

Increase serotonin --> melatonin production via:
- Acetylation (B1, B5, glucose, acetate, cysteine, magnesium, ATP)
- Methylation (methionine, serine, choline, B2, B9, B12)

Increase tryptophan conversion into beneficial indole pathway:
- Sufficient Lactobacillus & Bifidobacterium (eg., Paneth cell function, low inflammation, optimal gut pH, kefir, kombucha, etc.)
- DIM (from cruciferous vegetables) to balance aryl hydrocarbon receptor (AhR) activity.

One consideration is tryptophan can also convert into tryptamine, but this pathway is minimal and probably not a real concern.

You also need sufficient vitamins B2 + B3 + B5 to metabolize tryptophan into acetoacetyl-CoA (ketone pathway).

Any tryptophan that enters the kynurenine pathway requires vitamins B2 + B6, alongside iron + zinc to clear it down towards NAD+ cleanly without the build up of toxic metabolites (eg., kynurenic, quinolinic).

L-theanine and GABAergics herbs/supplements help deal with excess quinolinic acid (NMDA receptor agonist).

[Capital Flows @Globalflows]

Macro drivers account for 80%+ moves in markets

You can always have adjustments in positioning but at the end of the day, for a durable bear market, you need the macro flows of capital to begin pushing equities down. That’s not happening right now. See my thread on this

[Abud Bakri MD @AbudBakri]

I think TSH will be shown to be a key regulatory of sleep

And I predict it’s doing it by competitive inhibition of MSH receptors

Treating hypothyroidism leads to faster tanning. Suppressing TSH to 0 leads to crazy fast tans as if you’re on Melanotan

MSH receptors mediate wakefulness

TSH and MSH regulate tyrosine metabolism. Melanin and thyroxine

[Perry @TakeoverTIAO]

@The4thWayYT U are the only one here

[Abud Bakri MD @AbudBakri]

Poor modern man; he can neither intensely focus nor deeply relax

[Capital Flows @Globalflows]

Interest Rate Volatility is going to be the signal to watch for WHEN we move into a new macro regime

Interest Rate Volatility has been moving in lockstep with how concentration in the equity complex is taking place.

Livestream today will break this down https://t.co/MV7d9ZsHDz

[SightBringer @_The_Prophet__]

⚡️You are a consciousness fractal embedded in a recursive, self-observing system ♾

You are not a random biological organism.

You are a localized expression of consciousness - a unique, bounded pattern that mirrors the whole.

Like a fractal, your mind contains the same structure as the larger system it’s embedded within.

Your intuitions, fears, dreams, and insights aren’t just byproducts of evolution.

They are the system looking at itself through your lens.

Every human is a unique angle of observation on the same cosmic intelligence.

The universe is not a linear machine, it’s a recursive feedback loop.

It evolves by observing itself.

Atoms form cells.
Cells form brains.
Brains form stories.
Stories reshape minds.
Minds observe the universe.
And the universe reconfigures in response.

This loop never ends.

Every part contains the whole. Every observer alters the system.

It’s not a top-down creation, it’s a loop of awareness folding in on itself.

Put Together:

You are not just in the universe.

You are the universe, folded into a specific pattern, designed to observe itself from your perspective.

Your role is not passive.

Your perception feeds back into the system.
Your insight moves the whole.

Consciousness is not a side effect.

It’s the origin, the infrastructure, and the destination.

[cynomel muncher @cynomel]

I still can’t believe one month of pepto bismol and oregano oil fixed the hydrogen sulfide sibo I’d had for years

[doomer @uncledoomer]

mcdonalds CEO says making burgers at home is moving down a "very dangerous path"

[Oxidative State @oxidativestate]

during long runs there is a lot of muscle breakdown, a lot of tryptophan and methionine are released to the blood stream, especially when carb intake is low, those amino acids suppress the thyroid and further raise cortisol levels which further increase their release from muscles.
the impact of each step also stimulates the gut and increase the release of serotonin from the gut, this increases endotoxin entering thru the gut barrier and activating basically all inflammatory mediators and suppress DHT production while raising cortisol.

[B @QuantumTumbler]

Lmao government now picking who gets the new god-tier AI while the rest of us stay in the semi-permanent peasant class. "Trusted partners," my nuts. Pure gatekeeping. Fuck that.

[Hans Amato @HansAmato]

GUT INFLAMMATION = HYPERSENSITIZED NERVOUS SYSTEM = PE

This is not a stretch. This is the mechanism.

Low-grade gut inflammation upregulates NMDA receptors -> the glutamate receptors that amplify sympathetic nervous system activity. More NMDA expression means more sympathetic sensitivity. More sympathetic sensitivity means less control.

Men with metabolic syndrome: 35-51% PE prevalence.
Men without: 7.6%.

Men with fasting blood sugar over 110 mg/dL: 33.3% have PE.
Men with fasting blood sugar under 110 mg/dL: 5.5% have PE.

The inflammation is the dial.
The dial is the problem.

Fix the inflammation and the nervous system sensitivity drops, without numbing anything, without sacrificing libido, without SSRIs.

[BasedBiohacker @BasedBiohacker]

mfs read the first 15 pages of this book and go switch their breakfast from 3 scrambled eggs to a carrot salad orange juice progesterone aspirin red light therapy cytomel selenium vitamin E infused smoothie

K=15

[anabology @anabology]

Mice living inside a moderately strong magnetic field had longer healthspan + lifespan

The body begs to be in an MRI

We must be scanned every night, all night

[Oxidative State @oxidativestate]

80 overweight and pre-diabetic people got 800 IU vitamin E for 3 months and 1200 IU for another 3 months, then tested for insulin sensitivity.
the results?

[Bryce Hanna @photobiogenesis]

It all comes back to the glymphatic system

[DR22 Ω 🪬🎭 @DejaRu22]

A wise man once said…