🧠 Noonan syndrome (NS) & Neurofibromatosis type-1 (NF1) exhibited distinct impacts on white-matter microstructure. Using fractional anisotropy (FA) & axial diffusivity (AD), we observed differences in intra- & inter-hemispheric tracts. (3/7)
Our findings highlight that the Ras-MAPK pathway plays a key role in white-matter development in children, influencing connectivity & social communication. (7/7)
We used diffusion neuroimaging to uncover how pathogenic variants in the Ras-MAPK pathway affect brain development, particularly white-matter structural connectivity. Here’s what we found 👇(2/7)
🧵 Excited to Share Dr. Monica Siqueiros-Sanchez's latest paper on the impact of pathogenic variants in the Ras–mitogen-activated protein kinase (MAPK) pathway on white matter tracts in the human brain. (1/7)
NTAP is #HIRING! If you are a recent grad or have Physician Asst. / Nurse Practitioner entry-level experience, apply to this position on our #NF team that sees patients in the clinic and trials.
Physician Asst: https://t.co/XefQ1eoLXv
Nurse Practitioner: https://t.co/4bXOzN6ML8
1/6 #ChloeMcGhee latest research on neuroanatomical variation in children with RASopathies, specifically, Noonan Syndrome and Neurofibromatosis type 1 was published today in BP:CNNI @BiologicalPsyc1, a 🧵😍
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When looking at the syndrome level, #Noonansyndrome and #Neurofibromatosistype1 have a converging effect on surface area and cortical thickness but a diverging effect on subcortical volumes.