Fujimoto & Tamura show that glucose starvation remodels the yeast nucleus–vacuole junction via Ypf1 and INSIG homologs, Nsg1 and Nsg2, pointing to a role for fatty acid elongation-linked membrane remodeling in the spatial control of ergosterol biosynthesis https://t.co/XcNPqJgakH
Hello world, meet 1,000× Expansion Microscopy.
1,000,000,000× expansion by volume! A gel that starts at a few centimeters will then expand to the volume of an Olympic swimming pool. https://t.co/E43kxx4O5M
In our new bioRxiv preprint, work carried out between MIT and UMG, led by Helena Hu in collaboration with scientists from the labs of @eboyden3 Ed Boyden, Silvio Rizzoli, and myself, we present Thousandfold Expansion Microscopy.
By enlarging biological specimens across multiple rounds of expansion, molecular-scale features, as small as the distances between adjacent amino acids, can be visualized with conventional optical microscopes.
Democratizing super-resolution microscopy.
Our paper is officially published today.
https://t.co/CSKO3aJOcp
In this work, we rationally engineered split fluorescent proteins and enabled live-cell mapping based on fluorescence intensity modulation.
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