Teif Lab

Teif lab at @uni_of_essex. We work on nucleosomes, chromatin, TFbinding, CTCF, cfDNA. Find us at 🐘 and 🦋. [email protected]; [email protected]

[Teif Lab @TeifLab]

My first interview in a major podcast :) Quite an interesting experience! Thank you very much for inviting @epigenetics_pod

[Epigenetics Podcast @epigenetics_pod]

In this episode we talked to @TeifLab from the University of Essex about his work on nucleosome positioning in #cancer #diagnsotics. #podcast #Epigenetics

Listen here: https://t.co/sSlXoNeRfk

[Teif Lab @TeifLab]

Our new facility https://t.co/neCIpJaL4b

[Teif Lab @TeifLab]

Nucleosome aficionados! Our new review "Nucleosome spacing across cell types, diseases, and ages" is out in NAR: https://t.co/Z1TgEYxBH8

A huge effort to pull together what we’ve learned about nucleosome spacing in many systems. Enjoy!
#nucleosomics #nucleosome #chromatin #cfDNA

[Teif Lab @TeifLab]

Congratulations to Negin Behboodi on successfully passing your PhD viva! We are so proud of you! Keep an eye out for Negin's upcoming big papers! And thank you to the kind examiners @mikhailspivakov and @amarcobio!

[Teif Lab @TeifLab]

Some refs on nucleosome-mediated cooperativity in TF binding:
▶️Concept suggested by Polach & Widom, 1996: https://t.co/AzYYD6rcWa
▶️Our first single-bp resolution model, 2010: https://t.co/V20ceBhvXn
▶️Its application to TFs at enhancers, 2011: https://t.co/8sh4QSVVNc

[Teif Lab @TeifLab]

Congratulations to Amishasingh Beeharry for successfully passing the MSD viva! You are the best, Amisha! Thank you very much to the examiners, Abdenour Soufi and Toni Marco!

[Teif Lab @TeifLab]

@SylvanBacaLab @jberchuck @manoliskellis Congratulations on your preprint! You may be also interested in this one: https://t.co/jovpWLdoOu

[Teif Lab @TeifLab]

Great to see that this preprint used our software NucTools to calculate NRL, and reached conclusions confirming our previous paper, which reported effect of linker histones H1 on cfDNA fragmentation patterns and nucleosome spacing in cancer tissues/cfDNA https://t.co/eaPqOWINHN

[Teif Lab @TeifLab]

Great to see that this preprint used our software NucTools to calculate NRL, and reached conclusions confirming our previous paper, which reported effect of linker histones H1 on cfDNA fragmentation patterns and nucleosome spacing in cancer tissues/cfDNA https://t.co/eaPqOWINHN

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Excited to share our latest preprint by Alexis Yang and Gary Lee, in collab with the @jberchuck lab: https://t.co/cb3pRjketO. We found that transcription of enhancers (a mark of activation) causes distinct fragmentation patterns in #cfDNA.

[Teif Lab @TeifLab]

Happy to announce that our department (School of Life Sciences at the University of Essex) is upgraded to number 6th out of 91 UK universities in the subject area Biology according to the Guardian University Guide 2026. https://t.co/2zMcjHXpKq

[Teif Lab @TeifLab]

Very happy to contribute to this CTCF-nucleosome paper by @ElenaPugachev12 &Co. Exciting science and a cool journal cover!

[Elena Pugacheva @ElenaPugachev12]

Excited to share our latest study published in Nucleic Acids Research: https://t.co/ZSFQt4DI57
It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate CTCF’s constant struggle in shaping the 3D genome architecture.

[Elena Pugacheva @ElenaPugachev12]

Excited to share our latest study published in Nucleic Acids Research: https://t.co/ZSFQt4DI57
It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate CTCF’s constant struggle in shaping the 3D genome architecture.

[Teif Lab @TeifLab]

NHS announced that it will start offering first liquid biopsy tests for diagnostics of lung and breast cancer; also planning expansion to pancreatic and gallbladder cancers https://t.co/rPzQEm7Jaa

[Teif Lab @TeifLab]

We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and more https://t.co/7btyVTeDR8. Apply by 21st April 2025!

[Teif Lab @TeifLab]

Very happy to contribute to this paper about cfDNA in SCLC, led by the team of Anish Thomas. It's already online in Genome Medicine:

Takahashi et al., Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor https://t.co/tZyM0AAENU

[Pancreatic Cancer UK @PancreaticCanUK]

Early detection of #PancreaticCancer saves lives.

@TeifLab @EssexLifeSci are using cutting-edge technology to measure fragments of tumour DNA in the blood.

This "liquid biopsy" could provide an accurate & affordable new test for pancreatic cancer: https://t.co/ORTk18Xrhw

[IsabellaC @isabella_ciu]

2nd time at #FOG2025 (1st time presenting!), it never disappoints!✨

Great talks, groundbreaking research and good times with old&new friends

Huge thanks to everyone who stopped by my poster, truly grateful for the interest & discussions

Already looking forward to next year!🙌

[IsabellaC @isabella_ciu]

So excited for the festival and this great opportunity to present my research 😄

[Teif Lab @TeifLab]

@vitaliikl @StevenSalzberg1 @DaveJuergens The paper actually says they use ATAC-seq as input. It's not just from sequence

[IsabellaC @isabella_ciu]

Low quality picture but…
Had to show the matching glasses 🤭🤓