Tewhey Lab

Identifying the precise genetic mechanisms influencing human complex traits and disease risk at the @JacksonLab 🧬🐭💻✨ (tweets from students and post docs)

[Tewhey Lab @TewheyLab]

I know you thought it was just another Thursday but SURPRISE! The Tewhey Lab is officially on Twitter!!! 🥳 Watch this space for science, lab and other fun updates from @r_tewhey's lab ⬇️

[Rodrigo I Castro @i_rodcast]

Excited to share our sequence design work published in @Nature. I had the privilege of co-leading this effort alongside my friend and colleague @SagerGosai under the supervision of @r_tewhey, @ReillyLikesIt, and @PardisSabeti https://t.co/mJSvyaMUHT 1/7

[Sager Gosai @SagerGosai]

I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in @Nature. https://t.co/NJiCihH745 #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9

[Broad Institute @broadinstitute]

Using #AI, a Broad/@jacksonlab /@YaleMed team has developed a way to decipher the language of genetic switches that turn genes on and off, and designed new, synthetic switches that control genes' expression in specific cell types. https://t.co/7XzesmAm92 @ReillyLikesIt

[Tewhey Lab @TewheyLab]

Happy National Postdoc Appreciation Week to Tewhey Lab post-doc @takeshi_iwasaki!! 🥳🎉 Takeshi is studying regulatory variants in autoimmune disease and is actually this year’s @jacksonlab JAX scholar!!🏆🧬 #NPAW2024

[Tewhey Lab @TewheyLab]

Yes Takeshi!!!! JAX Scholar and Tewhey Lab post doc @takeshi_iwasaki talks about his work in the lab ⬇️🧬

[Layla Siraj, Ph.D. @LaylaSiraj]

Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays!
https://t.co/1eoN4OxAvd
See below for a 🧵. 1/n

[Anshul Kundaje @anshulkundaje]

This is by far the most convincing regulatory DNA synthetic design paper to date. Congrats to the authors 1/

[Steve Reilly @ReillyLikesIt]

SO happy this is live! See @SagerGosai tweet explaining our amazing collab with @i_rodcast, @r_tewhey, @PardisSabeti!

TLDR: Used AI to learn to 'read' the genome's regulatory code and 'write' new, synthetic functions. Evolution didn't create this neuronal enhancer, but it works!

[Niketa Nerurkar @niketa_n]

Thank you!!! Honored to be a Tufts GSBS Rosenberg Fellow 🥳 Grateful for the nomination from my program and the endless support from my PI and lab ☺️ @r_tewhey @TewheyLab

[Sager Gosai @SagerGosai]

I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. https://t.co/BqZYaGKwJX 1/n

[Niketa Nerurkar @niketa_n]

It’s official, the Twitter bio has been changed - ya girl’s a PhD candidate! 🥳 Grateful for all the support from my friends, family and committee! Super relieved to be done and even more ready for some of that Maine summer!! ☀️(Note: loading bar is not to scale…at all…)

[Tewhey Lab @TewheyLab]

Getting emotional about friendship and an ice bucket on a Thursday. 🥲🧊

[Steve Reilly @ReillyLikesIt]

@r_tewhey @TewheyLab the ice bucket, from corning, is truly an ELITE ice bucket. It's the Rolls Royce of ice buckets. The kind you get an unhealthy obsession with during your post doc, and won't buy for your own lab. Until your amazing friend buys one for you :)

[Tewhey Lab @TewheyLab]

Congratulations!! Kousuke's talk at @IMGC2023_sec was based on his paper on genetic variants of regulatory elements in autoimmune disease. Read Kousuke's BACH2 paper here: https://t.co/UbeniAsQzj

[Kousuke MOURI @kousuke_mouri]

Thank you so much @IMGC2023_sec for selecting my talk as an outstanding presentation. It is a great honor!

[Tewhey Lab @TewheyLab]

Congratulations to postdoc @kousuke_mouri for winning Outstanding Oral Presentation at @IMGC2023_sec 🧬 It's just BACH2 back wins for Kousuke!! 🥳

[Tewhey Lab @TewheyLab]

The Tewhey Lab can confirm that the Reilly lab has great science AND great holiday cards!!

[Steve Reilly @ReillyLikesIt]

We're expanding! post-doc and post-grad positions available!

YOU: into human evolution, deciphering regulatory variation, deep-learning, and/or developing functional characterization methods... + a lab that makes mildly over the top holiday cards.

https://t.co/G9V8twFfuD

[Tewhey Lab @TewheyLab]

Congratulations @r_tewhey on a great promotion seminar for Associate Professor @jacksonlab 🥳🧬🐭 Ryan's talk was titled "Defining the genetic basis of complex traits and disease through the (de)coding of regulatory syntax". Learn more about our lab at https://t.co/BlMVyyPOh8

[Tewhey Lab @TewheyLab]

REST assured - this is a cool paper :)
Read now at https://t.co/314wd1bW3O

[Kousuke MOURI @kousuke_mouri]

JAX wrote a nice article outlining our paper! Thank you!
https://t.co/ho84H2Wvb5

[Cell Genomics @CellGenomics]

Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay https://t.co/yiqPHD6soh