Associate Professor @UZH_en @Unispital_USZ @CCCZ_USZ studying the pathogenesis of cancer with a particular focus on TP53-mutant myeloid (pre-)malignancies
🔥New paper from our lab @UZH_en@Unispital_USZ@CCCZ_USZ 🔥
#ERCC6L2 disease is a relatively recently described inherited bone marrow failure syndrome. It is strongly associated with somatic #TP53mutations and #AML or #MDS development. 1/7
https://t.co/RCjzmBnb0Z
How does leukaemia develop? 🩸 How long does it take? ⏳
🌟 Our paper, started back when I was a PhD student in @jrblundell’s lab, is out today in @Nature 🌟
Yearly blood samples from women who developed AML in later life let us trace it back decades 👇
https://t.co/fqyOpc5OKH
Super happy to be back to my 2nd home, USZ in Zurich and see my ex mentor, colleagues and friends!!!! Was also honor to give a talk in Dept. of Onco-Hematology led by Prof. MG Manz.
At #EHA2026, the #HemaSphereAwards recognize authors of influential hematology publications. Congratulations to Ana Luísa Pereira, Serena Galli, and César Nombela-Arrieta for their study on bone marrow niches for hematopoietic stem cells👉https://t.co/OMQwfpVePP
Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] https://t.co/8kQZ0NWl7X
Ercc6l2 deficiency leads to replication stress, p53 pathway activation, and decreased Runx1 and Gata1 expression resulting in BMF. Read the plenary paper in Blood: https://t.co/tjdpXh2Nfk #plenarypaper#bloodjournal#p53
🔥New paper from our lab @UZH_en@Unispital_USZ@CCCZ_USZ 🔥
#ERCC6L2 disease is a relatively recently described inherited bone marrow failure syndrome. It is strongly associated with somatic #TP53mutations and #AML or #MDS development. 1/7
https://t.co/RCjzmBnb0Z