The Clevers Lab

Hubrecht Institute, Utrecht, The Netherlands

[The Clevers Lab @TheCleversLab]

Using snake airway organoids, we modelled reptile virus infection in vitro. With a new Python Regius reference genome, we show that our organoids contain multiple cell types, could mount an immune response and respond to antivirals.

Paper: https://t.co/d6zR8lQEke

[Organoid News @organoidscience]

Our countdown is never complete without a @TheCleversLab story! 😎

Their study of an in vitro model of mouse dorsal tongue epithelium holds 4th place in our countdown. 👏

If you missed the article in September, read it now. 👇

https://t.co/9Zx1uselD0

[Ina Sonnen @SonnenKatharina]

Using fluorescence real-time imaging and an in vitro implantation model, we show that human embryo attachment begins with direct cell fusion via syncytin-2–MFSD2A interaction.
With @TheCleversLab.
Great work by @NoordzijTomas & @CelottiMartina! @_Hubrecht
https://t.co/cG8P4J7Pbm

[Hans Clevers @HansClevers]

Daisong Wang and Sangho Lim describe human gut organoids with Peyer's patch M cells. M cells not only transport antigens: like professional antigen-presenting cells, they process and present gluten (the celiac disease antigen) directly to T cells https://t.co/q6Efm59SZi

[The Clevers Lab @TheCleversLab]

4/4 This work was a true team effort between @_amolf, @ihb_research, and the @_Hubrecht — led by @DanielKruegerDK and Kasper Spoelstra. Huge thanks to all collaborators for making it possible.

[The Clevers Lab @TheCleversLab]

1/4 Gut renewal is not passive “crowd control.” Instead of being pushed out by crowding or dying from apoptosis, cells compete in a mechanical tug-of-war. Weaker cells are eliminated—reframing intestinal homeostasis as a force-regulated process. https://t.co/y17pTHBkuj

[The Clevers Lab @TheCleversLab]

3/4 This reveals a safeguard mechanism: epithelial cells constantly test each other’s mechanical strength. Too little (or too much) force destabilizes the barrier, linking extrusion to diseases like tufting enteropathy. Gut renewal is an active, force-regulated process.

[The Clevers Lab @TheCleversLab]

Do you want to learn how to make mouse thymus organoids?

Our lab recently published a STAR Protocol on generating thymic epithelial organoids from adult mouse thymus tissue.

Read it here: https://t.co/6cx5mM1C2E

#Thymus #Organoids #STARProtocol #TEC

[The Clevers Lab @TheCleversLab]

Our PhD student Sam presented our work on thymus organoids at this year’s Global Thymus Network meeting, ThymUS 2025.

#ThymUS2025 #Organoids #Thymus

[The Clevers Lab @TheCleversLab]

Check out new @TheScientistLLC article highlighting our postdoc @AmandaARolf ’s work on a novel pancreatic organoid model that includes all three key cell types, offering new insights into pancreatic development: https://t.co/Aa1jQotXit

[The Clevers Lab @TheCleversLab]

📢New human fetal pancreatic organoid model generates all three key cell types of the pancreas. New paper in @CellCellPress by @AmandaARolf , @HansClevers and collaborators. See the article here: https://t.co/xcuc8drybh

[The Clevers Lab @TheCleversLab]

Recent work from our lab explored the role of multiple nuclear receptors in the human small #intestine. Using #organoids and small molecules, we activated and then studied one nuclear receptor at the time through transcriptome characterization.

https://t.co/DtD0iWurgL

[The Clevers Lab @TheCleversLab]

Watch back the 2024 EMBL Kafatos Lecture where ⁦@HansClevers⁩ presented about the application of organoids in disease modeling at the ⁦@_knaw⁩ Amsterdam. #embl #knaw #organoids https://t.co/JcgrhhDx03

[Hans Clevers @HansClevers]

Exciting study! Organoid models reveal a novel role for human tuft cells in gut regeneration upon damage. Video: Tuft cell division is triggered by IL-4, visualized in human gut AVIL-Clover reporter organoids (Credit: Daniel Krueger) https://t.co/gXhem2rw0B

[The Clevers Lab @TheCleversLab]

Our postdoc @TheodoreGrenier visiting the @ENSLyon to talk about his research on #IBD and #organoids.

[The Clevers Lab @TheCleversLab]

One bacterial protein as a complement to #Matrigel/#BME: The #integrin -binding domain of the Yersinia bacterial protein Invasin, coated as a single protein, maintains a defined long-term culture of various epithelial cells as “2D #organoid sheets”.

https://t.co/yeT3ieLmhf

[The Clevers Lab @TheCleversLab]

The Clevers lab is represented at the #ERSCongress in Vienna, with @nella_dost presenting her primary human alveolar lung organoid model @EuroRespSoc #organoid

[The Clevers Lab @TheCleversLab]

Do you want to genetically engineer your organoids rapidly and accurately? Check out our recently published STAR Protocol about implementing Base and Prime Editors in organoids! A protocol developed by @CelottiMartina and @geurts_maarten
https://t.co/dI1J8W9Vgr

[Jens Puschhof @JensPuschhof]

Another great collaboration with @Axel_R_Huber, @Cayetanopm, @JoskeUbels, @HansClevers, @BoxtelLab and many others. Random forest trained with #organoid #colibactin mutations => identification of pks-linked mutations in every 8th #colorectal tumor genome! https://t.co/HUbf9A3NCf.