Karen Shore

MS4 @UTSWMedCenter
Incoming resident @MGBpathology

[Karen Shore @TheShorePath]

Stained glass or adenomatous hyperplasia of the thyroid? There's so much beauty in pathology!

@ElaineHuMD @Maicroanatomy @JuanPathMD @LordoftheSlides @GIJamesMD

[Karen Shore @TheShorePath]

Dx: Signet ring cell adenocarcinoma (note the abundant intracellular mucin that peripherally displaces the nucleus)
Unfortunately, this is an aggressive cancer that carries a poor prognosis as it is typically diagnosed at advanced stages

[Karen Shore @TheShorePath]

You receive a GI case and see this. Diagnosis? Are you worried for the patient?

[Karen Shore @TheShorePath]

Ever wonder what scabies looks like under the microscope? They really do burrow!
#Pathology #pathX #dermpath

[Karen Shore @TheShorePath]

Adenoid cystic carcinoma of the breast (ACCB) can mimic CS. How can we differentiate?
- ACCB diagnosis requires dual population of cells-- basaloid and luminal epithelioid cells
- IHC: Smooth muscle myosin heavy chain and calponin are strongly positive in CS and negative in ACCB

[Karen Shore @TheShorePath]

You see these collections of spherules filled with an acellular pink material on a breast biopsy. Diagnosis?
#pathology #pathX

@ElaineHuMD @Maicroanatomy @JuanPathMD @LordoftheSlides @GIJamesMD

[Karen Shore @TheShorePath]

Collagenous spherulosis (CS)!
This benign finding is caused by an accumulation of basement membrane material forming eosinophilic spherules.

[Karen Shore @TheShorePath]

How can we remember this?
CAIX is overexpressed in hypoxia, and hypoxia inducible factor (HIF) is controlled by the VHL gene (associated with RCC)!

[Karen Shore @TheShorePath]

How can the CAIX (carbonic anhydrase IX) IHC stain be used to differentiate subtypes of renal cell carcinoma (RCC)? #pathology #pathX #gupath

@ElaineHuMD @Maicroanatomy @JuanPathMD @LordoftheSlides @GIJamesMD

[Karen Shore @TheShorePath]

CAIX is a membranous stain:
- Box-like/complete staining= clear cell RCC
- Cup-shaped staining= clear cell papillary RCC
- Focal (often <50%)= papillary RCC
- Negative= chromophobe RCC

[Karen Shore @TheShorePath]

@RepettoF_MD Thank you Federico!! Looking forward to seeing you again!!

[Karen Shore @TheShorePath]

Beyond excited! Can't wait to join the MGB path family!

[Mass General Brigham Pathology @MGBpathology]

We couldn’t be more thrilled to introduce this stellar new class of 19 (yes, 19!) PGY1s joining the Mass General Brigham pathology family! 🥳
Welcome to the team — we can’t wait to have you on board and see you thrive! 🧬🔬💫

[Karen Shore @TheShorePath]

@GinaBortoletto @MGBpathology Congratulations! Excited to meet and work with you!! 😊

[Karen Shore @TheShorePath]

Microscopic flowers-- so cute!

@ElaineHuMD @Maicroanatomy @JuanPathMD @LordoftheSlides @GIJamesMD

(Asteroid bodies in multinucleated giant cell)

[Karen Shore @TheShorePath]

MRI: High signal intensity deposits, demonstrating rupture with free silicone conglomerates in breast parenchyma
H&E: Refractile foreign material (silicone) with giant cell reaction

[Karen Shore @TheShorePath]

Radiological-pathological correlation in breast in patient with history of silicone implants (MRI and H&E) #pathology #pathX
@ElaineHuMD @Maicroanatomy @JuanPathMD @LordoftheSlides @GIJamesMD

[Karen Shore @TheShorePath]

Pseudoangiomatous stromal hyperplasia (PASH)
Characterized by complex inter-anastomosing slit-like spaces in a dense collagen stroma. "Pseudoangiomatous" because the spaces resemble vascular spaces. It's benign!

[Karen Shore @TheShorePath]

You see this in a breast biopsy… what is the diagnosis?
#pathology #pathX

[Karen Shore @TheShorePath]

The Giemsa stain can also help highlight the Leishmania parasites!

[Karen Shore @TheShorePath]

Saw 2 of these cases in 2 weeks earlier this year. Both patients had recently immigrated from South America and presented with enlarging ulcerative lesions on their upper extremities. Diagnosis? #pathology #PathX #dermpath #pathmatch2025

[Karen Shore @TheShorePath]

Cutaneous leishmaniasis! On H&E, we can see intracellular leishmania amastigotes within monocytes/histiocytes. Never thought I'd see this outside of SketchyMicro