The Syndemic News

As the #SARSCoVx / #CoViD pandemic ripped it created second-order effects, thus becoming a #syndemic #permacrisis.

[The Syndemic News @TheSyndemic]

Russia/Ukraine and now this are not totally separate from #SARSCoVx / #CoViD - much like WW1 and WW2 are not totally separate from the “Spanish” flu. Neurocognitive effects create perfect conditions for autocrats and wars.

[Velina Tchakarova @vtchakarova]

I’ve been through four systemic risk-induced crises so far: GFC, Covid, Russia/Ukraine, & now this.

This is by far the worst!
I’m just devastated by the imagination of the global impact, the human loss, the severe poverty crisis & the political turmoil that are about to hit us.

[Keith @keetmuise]

Covid infections cause…
Lower Sperm Count
Reduced Sperm Quality
Erectile Dysfunction
Female Fertility Problems

But media is promoting is blaming smart phones for the concerning drop in birthrates. Not saying Covid is the only reason for the decrease, but it is a major one.

[Guenter GR @GrGuenter]

Die bisher beste Long Covid Studie wurde nun veröffentlicht, mit überraschenden Ergebnissen die neue Therapieansätze ermöglichen. Vereinfacht gesagt: Long Covid wird (in den untersuchten Bereichen) von Autoantikörpern im Blut verursacht, die dann sehr wichtige Teile des Gehirns angreifen und eigentlich alle Symptome erklärbar machen.

Wichtige Erkenntnis: Long Covid Patienten dürfen keinesfalls Blut spenden denn es scheint übertragbar zu sein über jene Autoantikörper im Blut!

Toller Artikel, verständlich geschrieben:
https://t.co/GDxqontAb1

[🎒Joanna Teglund✊😷🍉Human life is sacred @JoannaTeglund]

1. If you are curious how much COVID—regardless of severity—increases the risk of mental disorders, this study is for you:
major depressive disorder 3.74x
generalized anxiety disorder 2.85x
PTSD 2.32x
“lost interest in most things” 3.84x
"feeling nervous, anxious or on edge”1.82x

[Harry Spoelstra @HarrySpoelstra]

Persistent Cerebral 18-FDG PET Changes in Patients With Long COVID Presenting With Fatigue and Post Exertional Malaise

🚨We already knew Long COVID brain damage could last 6 months.
Now this new PET scan study proves it’s still there at 2 YEARS and counting.
Hypometabolism hits the left sensorimotor cortex (movement + body sense), left superior parietal (spatial awareness + attention), and bilateral visual cortex (raw sight processing).
This is NOT just “tired.”
This is a broken sensory-motor command center.
Is this the start of a lifelong neurological disease?

➡️Mayo Clinic observational cohort study of 40 Long COVID patients (70% female, median age 53) from a specialized clinic who underwent brain 18F-FDG PET-CT scans 17–149 weeks (median 62 weeks) after SarsCoV2 infection,

➡️73% had predominant fatigue with post-exertional malaise (PEM),

➡️This group showed statistically significant cerebral hypometabolism vs. non-PEM patients in the left sensorimotor cortex (p=0.0253), left superior parietal cortex (p=0.0276), and bilateral primary visual cortex (p=0.0096 and 0.0016),

➡️Abnormalities persisted already up to ~2 years post-infection,

➡️Scans used pons-normalized Z-scores against age/gender-matched controls with common comorbidities included psychiatric, GI, and cardiovascular conditions,

➡️Caveat: No references to vaccination status and/or reinfections,

➡️Authors propose 18F-FDG PET-CT as a potential diagnostic and therapeutic biomarker for the fatigue/PEM phenotype of Long COVID.

‼️So, AGAIN, Long COVID fatigue and PEM have a demonstrable, persistent neurological signature! Cerebral hypometabolism, still detectable on PET scans up to two years later and hits the left sensorimotor cortex (movement + body sense), left superior parietal cortex (spatial awareness + attention), and bilateral primary visual cortex (raw sight processing).

This isn’t just “tired.”

It’s a broken sensory-motor command center.

😡Study proves LC is biologically real, not psychosomatic or any other stupid FND diagnosis.

Without urgent validation of this biomarker and targeted therapies, patients will continue to be dismissed despite objective brain damage!
#AvoidSars2 #AvoidReinfections #BrainDamage
https://t.co/OfoOlgDyt0

[tern @1goodtern]

So the people triumphantly announcing the end of excess deaths are highlighting three things:
That Covid has caused excess deaths
That something is still causing excess deaths
And that they don't understand excess deaths.

[James Throt MBBS, MD, PhD, FRCPath @JamesThrot]

As a neurologist, it is now patently clear to me that the vast majority of people on the planet are suffering from neuroinflammation or brain damage (likely both)

The way people speak & behave has changed. Markedly so.

Whether irl, or via messaging/social media. It’s noticeable

[Danielle Beckman @DaniBeckman]

Happy to share that after a prolonged peer-review process, our review covering the major Neuroinflammatory events in #LongCovid was accepted today for publication at @Transl_Psych from the @NaturePortfolio! Coming soon, but preprint available here: https://t.co/Pa1ME9eRpT

[tern @1goodtern]

The only way they can not put this together is to wilfully not put it together.

[Harry Spoelstra @HarrySpoelstra]

Beyond brain fog: viral proteins as convergent drivers of neuroinflammation and proteinopathy

🚨“COVID-19 never really leaves your brain.”

New science review proposes SARSCoV2 viral proteins stay behind as long-lived toxins, triggering chronic neuroinflammation and planting the seeds of Alzheimer’s and Parkinson’s, even after mild infection.

This very interesting and eye-catching GERMAN review reframes post-viral neurological syndromes( L0ngC0vid) as driven by persistent viral proteins acting as long-term toxins ("protein-as-pathogen" model), not just the active infection!

➡️Core mechanisms:
- SARSCoV2 Spike and OTHER viral proteins activate glial TLR4/TLR2 receptors, triggering chronic neuroinflammatory cascades via NLRP3 inflammasome,
- They also disrupt autophagy, allowing toxic protein aggregates (tau, amyloid-beta, α-synuclein) to accumulate and seed neurodegeneration,

➡️SARSCoV2 specific evidence:
- Animal studies show Spike protein alone (without live virus) induces TLR4-mediated cognitive deficits, memory impairment, synaptic loss, and sustained neuroinflammation, recapitulating post-COVID syndrome,
- Spike binds α-synuclein, accelerating Parkinson-like clumps,

➡️Human data evidence:
- Millions experience "brain fog,"
- Post-COVID patients exhibit measurable brain damage: cortical thinning, hippocampal iron accumulation, and biomarkers of ongoing neuronal injury,

➡️Broader risks:
- Even mild infections leave lingering proteins that promote Alzheimer’s and Parkinson’s-like pathology via shared pathways,
- Same pathways seen in influenza, dengue, West Nile etc,
- Mild infection = no protection,

‼️So, according to this review, the “protein-as-pathogen” model makes it crystal clear: every new SARSCoV2 infection (even mild or asymptomatic) deposits more of these long-lived toxic viral proteins into the brain. They don’t fully clear. They accumulate.

Each reinfection reloads the TLR4/TLR2 → NLRP3 inflammasome trigger and further collapses autophagy, speeding up the tau/amyloid/α-synuclein proteinopathy and neurodegeneration.

SARS-CoV-2 does not just infect.

It weaponizes its own proteins as long-lived intracellular saboteurs.

Millions are probably already carrying this hidden payload.

This is not brain fog.

This is a silent, population-scale reprogramming of human brains toward dementia-like decline.

The long-term neurological cost will probably dwarf the acute pandemic itself!
#AvoidSars2 #AvoidReinfections
https://t.co/x0oxacaNwl

[Conor Browne @brownecfm]

I know I've said this many times before on this platform, but the moment I learned anosmia was a symptom of Covid-19 was the moment I decided I was going to do everything possible to avoid getting it. I knew anosmia was an early prodromal symptom of Parkinson's Disease.

[tern @1goodtern]

Good.
I'm glad WHO has warned that Andes Hantavirus may be spread person to person by airborne particles.

That's what they should have done with Covid in Feb 2020.

Then in March 2020 they should have said "Yes. There's no maybe. Covid is spread by airborne particles".

[Chris Murphy 🟧 @ChrisMurphyCT]

This Ebola outbreak has been a slow motion disaster - 900 cases and and now threatening the U.S..

We know how to stop outbreaks like this. But Trump chose not to stop it. He destroyed our global health team, deliberately exposing us.

1/ Here's the story of how this happened.

[Dan Elton @moreisdifferent]

An N95, taken off occasionally doesn't provide 100% protection. But even if you get sick while 😷, it's generally lower viral load, leading to milder illness. Each CV-19 illness causes persistent IQ loss that might be permanent. The degree of IQ loss is correlated with severity:

[Farrukh @implausibleblog]

Victoria Derbyshire, "If you've had covid, did you think the virus has affected your memory, or ability to think straight? Maybe you described it as brain fog?"

A must watch report by #Newsnight on how having covid could lead to a modest cognitive decline commensurate with a 3 point loss in IQ

[Dr. Sean Mullen @drseanmullen]

Please put aerosol scientists and engineers back in charge of public health.

We built infectious disease policy around outdated droplet assumptions while ignoring aerosol physics, ventilation, and indoor air quality.

If your infectious disease training still treats airborne transmission like a rare exception instead of a central mechanism, your curriculum is obsolete.

Public health accreditation bodies should immediately reevaluate training standards for airborne disease prevention, ventilation, filtration, respirators, and aerosol science.

Droplet dogma has already cost enough lives.

[Zdenek Vrozina @ZdenekVrozina]

A Spanish multicentre cohort study followed patients for up to 5 years after SARS-CoV-2 infection.

At the 1-2 year follow-up, 56% of participants reported at least one persistent symptom. The prevalence was similar in hospitalized and non-hospitalized patients, 57.6% vs 53.0%.

The key finding comes from the 5 year follow-up.
14.3% of the entire cohort sought medical care for symptoms compatible with a post-COVID condition.
Despite this, a formal diagnosis of long COVID was recorded in the medical records of only 3.4% of the whole cohort.

The study shows a clear gap between the number of people with persistent symptoms or post-COVID compatible healthcare needs and the number of cases formally documented as long COVID. The healthcare system often fails to recognize these symptoms, link them to prior infection, or code them as long COVID.

And this is not a trivial burden for the healthcare system. It may be dispersed across ordinary clinical encounters, without being recognized.

An additional 15% of people seeking care years after infection has the potential to create a long-term, difficult-to-absorb burden for the healthcare system.
@adamvojtech86
An exceptional performance @szupraha @vlvalek @ZdravkoOnline

[Ruth Ann Crystal, MD @CatchTheBaby]

COVID raises your shingles risk.

New data from 110,000+ patients out of Taiwan shows that post-COVID Shingles also raise risk of
➡️ Bell's palsy
➡️ Guillain Barré
➡️ Myasthenia Gravis

Worst of all? Neurological vulnerability lasts for at least 3 years. https://t.co/W2MDpgMdmx

[The Syndemic News @TheSyndemic]

@leanhealth @alfwarrior @ukhadds He does not.
It is.

[Barry Hunt @BarryHunt008]

Pardon me, professor, but you're clearly making this up out of thin air

Ebola virions are going to be packaged in the same size aerosol bubbles that any other virus would be packaged in by respiratory activity

The aerosols are NOT bigger & heavier