🐷➡️🧬 In the first pig-to-human kidney transplant, a multiomics approach demonstrated that persistent innate immune activation (monocytes/macrophages) remains a key barrier. Better control of innate immunity will be critical for future success.
High-dimensional immune profiling of a living recipient of a pig-to-human #xenotransplant provides insight into the immune landscape of #xenotransplantation and directions for improved #immunosuppression strategies.
https://t.co/JlMV93nWrU
Incredible opportunity to lead our Living Donor Kidney Transplant Program @mgh_transplant
Join a collaborative, high-volume team (>240 tx/year) with real momentum in innovation and program growth (tolerance/xeno)
Know someone great or interested yourself:
https://t.co/nmz2bj9ury
COTS Guest Symposium at IMMUNOLOGY2026™ in Boston April 17, 2026 8:00–9:30 AM : The Immunology of Xenotransplantation
Moderators: Dr. Anita Chong, Dr. Thiago J. Borges
Speakers: Drs. David K. C. Cooper, Valeria Mas, Thiago J. Borges, Brendan Keating
https://t.co/YrSY0xeo9x
We’re very excited to be hosting the first Glomerular Disease Conference in Boston on May 30th!
Join us to learn what’s new in glomerular diseases from world-class experts.
In-person and virtual options available.
Fellows/trainees can attend for free. DM for details.
Historic moment in transplant medicine. Tim, our @mgh_transplant xenotransplant patient, who previously received a gene-edited pig kidney and was off dialysis for 9 months, has now received a human kidney. A new chapter in care and hope. https://t.co/Y5TwaknZVr
I’m very proud to have been the first Editorial Fellow on the Basic Science track @amjtransplant
This experience has been incredibly valuable for my development as a scientist. I strongly recommend this program to anyone interested in academic publishing.
American Journal of Transplantation is now accepting applications for the AJT Editorial Fellowship Program!
Work alongside journal editors. Build peer review and communication skills.
Applications open through Jan 31
https://t.co/O13k7DlLre
A brief T–cell–mediated rejection occurred early, likely due to residual lymph node immunity, but was successfully treated. No antibody-mediated rejection was seen. @LVRiella@MassGeneralNews
🐷➡️🧬 In the first pig-to-human kidney transplant, a multiomics approach demonstrated that persistent innate immune activation (monocytes/macrophages) remains a key barrier. Better control of innate immunity will be critical for future success.
High-dimensional immune profiling of a living recipient of a pig-to-human #xenotransplant provides insight into the immune landscape of #xenotransplantation and directions for improved #immunosuppression strategies.
https://t.co/JlMV93nWrU
Hot off the press @NatureMedicine: We report the first high-dimensional immune profiling of a living human recipient of a gene-edited pig kidney at @MGH_Transplant / @MGBKidneys, defining the evolving human xeno-immune response over time. https://t.co/to6CdMjv9B
In honor of Richard Slayman, the first pig kidney recipient, we hosted a workshop gathering global experts in xenotransplantation to explore unpublished clinical and ethical advances in kidney, heart, and liver transplantation.
#Xenotransplantation#TransplantInnovation
Scientists have found that C/EBP⍺ activates an IRF8 #enhancer, driving its expression in early myeloid progenitors and specifying type I conventional #DendriticCell lineage. @washu_pathology@JingNeticist
Read more in Science #Immunology: https://t.co/stvtqL9ZPb
He’s thriving nearly 4 months after receiving a gene-edited pig kidney at @mgh_transplant@MGHSurgery @MGHKidneys @harvardmed. “He was tired of just surviving. A pig kidney gave him a shot at living.” @CNN
🔗 https://t.co/h0noI42DKc
🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/5
https://t.co/Z4FqTvFE8X
💡 Takeaway: Innate immune checkpoints like Siglec-E/7/9 are emerging as crucial regulators of transplant rejection. 4/5
📄 Newsroom @MGBResearchNews: https://t.co/BF1iVaHTP0
🚨 Breaking Records Again! 🚨
For 13 years in a row, our transplant teams have saved more lives through #OrganTransplantation than any hospital in New England.
👏 Shoutout to our patients, care teams and researchers for an amazing year in 2024! #TransplantInnovation#DonateLife