Amara

Pathologist #Dermpath #Breastpath #GIpath

[Henry C Fung| MM, lymphoma, leukemia & CART @HenrychihangFu1]

CD30⁺ lymphomas: from biology → diagnosis → therapy 🎯

CD30 is not a diagnosis.
It’s a shared activation marker across distinct lymphomas.

🧬 EBV can be + in BOTH:
• Hodgkin lymphoma
• DLBCL

So CD30⁺ + EBV⁺ ≠ one disease.

👉 Diagnosis requires:
• Morphology
• Immunophenotype (CD20 / CD15)
• Clinical context (mediastinum?)

⚠️ The risk:
Misclassification → wrong therapy

💊 Why this matters:
CD30 is targetable
→ Brentuximab vedotin (including FDA-approved R² combination in R/R DLBCL)

💡 Take-home:
Same marker ≠ same disease ≠ same treatment

CD30 is a bridge—not a diagnosis.

#lymphoma #Hemetwitter

[Janira Navarro @Janiranavarro]

Endometrial metaplasias:
- Myomatous stromal metaplasia

Desmin stain (Pic 2)
Incidental finding

#everydayGYN #pathology #PathX

[Miruna Popescu, MD @MirunaPopescu13]

Testicular tumor in a young boy.
What's your diagnosis?

#GUPath #PathTwitter #Crittersontwitter

[Ahmed Montasser @AMontasserMD]

Weekend treat 🍬

C L A S S I C 🏛️

Organ? diagnosis ? 🤔

#Pathology #Endocrine #PathTwitter #PathX

[Charlie Herndon @DrCycloPath]

#TooCloseToDiagnose? 🧐
A. Myrmecia
B. Epidermodysplasia verruciformis
C. Paget's disease
D. Verruca vulgaris
#Pathology #Dermatology #Dermatopathology #DermPath

[Kalyani Bambal @kriyer68]

ARCHITECTURAL PATTERNS:Cutaneous Spindle Cell Neoplasms.
Idea:APLM2018;142:958-972
#dermpath #bstpath #surgpath #pathology #pathologists @JMGardnerMD @JMcMahonG @histiocytosisX @DrFNA @GeronimoJrLapac @BinXu16 @jaimearturomc @VijayPatho @mreyesm @Alipathy

[Janira Navarro @Janiranavarro]

Bladder Plasmacytoid Urothelial Carcinoma

Pitfall ⚠️: It can stain CD138 positive (CD138 can stain epithelium).

Run a panel of IHC (pic 2).

Plasmacytoid histology can be seen in different neoplasms (see pic 3).

Dr. Magi-Galluzzi – 2025 Diagnostic Pathologic Update #USCAP #pathology #PathX

[Janira Navarro @Janiranavarro]

Diagnosis of metastatic prostatic carcinoma - IHC

Dr. Magi-Galluzzi - 2025 Diagnostic Pathologic Update #USCAP #pathology #PathX

[Janira Navarro @Janiranavarro]

GATA3 IHC is useful but you need to be aware of the pitfalls...

Dr. Magi-Galluzzi - 2025 Diagnostic Pathologic Update #USCAP #pathology #PathX

[Samson W. Fine, MD @rovingatuscap]

Stunning contrast between flat urothelial carcinoma in situ (right side of each image) and reactive urothelium (left side)

CIS➡️enlarged, irregular, & hyperchromatic nuclei

Reactive➡️small, uniform nuclei w/vesicular chromatin + intraepithelial acute & chronic inflammation

[Janira Navarro @Janiranavarro]

Vulva - Cutaneous syphilis - Condyloma lata
- Epithelial hyperplasia (Pic 1)
- Plasma cell infiltrate with scattered macrophages and lymphocytes (Pic 2)
- Spirochete IHC stain (Pic 3)

#everydayGYN #PathTwitter #pathology #PathX

[Oscar Lopez-Nunez @olopeznu]

Juvenile Polyp
✔️Most common polyp in children
✔️More than 1/2 in the rectosigmoid colon
✔️Can be sporadic or syndromic (JPS)
✔️SMAD4/BMPR1A mutations ~ 50% of JPS families
✔️Histologically identical polyps can be seen in other hamartomatous polyposis syndromes
#PediPath #GIpath

[Janira Navarro @Janiranavarro]

Breast-When evaluating possible ADH or DCIS involving a papilloma:

- Look for areas of pure epithelial proliferation with few fibrovascular cores.
- Examine the duct wall or neighboring glands outside the papilloma; if involved by DCIS or ADH, compare their morphology to the proliferation that inside the papilloma to make the diagnosis.
- Papilloma involved by ADH: <3 mm.
- Papilloma involved by DCIS: ≥3 mm.
- Pitfall: Myoepithelial markers are not reliable for distinguishing papilloma with UDH from those with ADH or DCIS (papillomas with ADH and DCIS can retain myoepithelial cells).

Dr. Lerwill - 46th Annual Current Concepts in Surgical Pathology #pathology #PathX #Pathtwitter

[Security Trybe @SecurityTrybe]

Spam Email: Can you spot the difference?

[Modern Pathology @ModernPathology]

Dr. Sarah Dry has published a wonderful review of fatty tumors and nerve sheath tumors. Check out this malignant triton tumor (malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation) - the muscle differentiation is obvious on H&E.
Dry S. Updates in Peripheral Nerve Sheath and Adipocytic Tumors. Mod Pathol. 2025 Nov 1;39(1):100929. PMID: 41183597.

[Pooja Navale MD @navale_pooja]

Endoscopic surprise → histologic answer: Amyloid deposition in the stomach, it mimicked GAVE on endoscopy. Congo red tells the story.

[Elizabeth Montgomery, MD @LizMontgomeryMD]

This adrenal cortical carcinoma presented as a liver mass. The CK8/18 highlights a tiny rim of compressed liver at the periphery. On a prior needle biopsy it was a mimicker of hepatocellular carcinoma but we figured it out thanks to modern immunohistochemistry.

[Nico Gagelmann @NicoGagelmann]

You're called early morning on a Sunday. Patient with anemia, abdominal pain and history of heavy drinking. Diagnosis?

[Syed Z. Ali @sza_jhcyto]

Airdrying artifact rendering a "pseudo-keratinized" appearance in this "Anaplastic Thyroid Carcinoma" on Pap stain. (FNA)

[Surgical Pathology Cases @surgpathcases]

Breast, 60y

#pathology #patologia #pathoutpic #breastpath #breastpathology