@jrossibarra @arunsethuraman @mbhufford @druncie Wow, thanks Jeff for the beautiful story. I would only add that you never know what a few beers sitting with Hank Bass at MGC, discussing his idea of using a combined endo/exonuclease to footprint TFs, can do to you. So many other ideas died that night 🤣!
Excited! A fun collaboration with Thomas Hartwig and led by Julia Engelhorn, is out on biorxiv. https://t.co/2k1Dd0OXIp Thomas's group has led the way pioneering the use of MOA-seq, an approach that uses mnase to digest DNA and find *all* the spots proteins are bound to DNA 1/7
We then partition additive genetic variation (Va) for >130 phenotypes (thanks @MerKhaiBurch!). We find that the majority of Va for ~70% of phenotypes can be explained by the small number of bQTL, even when accounting for background (bgSNPs) and the rest of the genome. 6/7
At least 5 independent origins of C3-C4 intermediate photosynthesis in the Brassicae tribe of the Brassicaceae:
Brassicaceae display variation in efficiency of photorespiratory carbon recapturing mechanisms https://t.co/2NElRdt457
Thanks to all our colleagues from @ceplas_1, incl. @apmweber, for visiting @LeibnizIPK for three days full of interesting discussions and presentations. We are already looking forward to many joint projects!