Toby C. Cornish MD, PhD

Clinical Informaticist, GI Pathologist, Professor of Pathology, Medical College of Wisconsin

[Toby C. Cornish MD, PhD @TobyCornish]

Thank you all for joining in on our April 1st fun 😁 maybe we'll have an opportunity to do this IRL one day @DaveMcPath411 @SphereVegas

[API - pathbytes @pathbytes]

4/29 Join Dr. David McClintock & Dr. Clare McGenity for a free webinar! Dr. Hooman Rashidi joins for a discussion moderated by Dr. Keluo Yao. Sponsored by Aira Matrix with additional funding from Mopec Group. https://t.co/96P7UCdd79
#digitalpathology #pathology #ai #pathologist

[Toby C. Cornish MD, PhD @TobyCornish]

Thank you all for joining in on our April 1st fun 😁 maybe we'll have an opportunity to do this IRL one day @DaveMcPath411 @SphereVegas

[Toby C. Cornish MD, PhD @TobyCornish]

Pleased to announce that Dave McClintock and I have displayed and navigated a whole slide image on the Las Vegas Sphere — 580,000 sq ft of H&E at 256 megapixels. Press release follows. 1/

#digitalpathology #PathTwitter @dpatweet @SphereVegas

[Toby C. Cornish MD, PhD @TobyCornish]

About the team:
Dave McClintock, MD — pathology informaticist and monitor enthusiast who has long believed the problem with digital pathology is that the screens aren't big enough.

Toby Cornish, MD, PhD — informaticist specializing in studies that are about themselves.

[Toby C. Cornish MD, PhD @TobyCornish]

Technical Specifications:
Display: Sphere exterior LED
Resolution: 256 megapixels
Display area: 580,000 sq ft (~13.3 acres)
Construction cost: $2.3 billion
Viewing distance: 0.3–2.0 miles
Diagnostic accuracy: 100% (n=1)
Nachos consumed: 2 trays

[Toby C. Cornish MD, PhD @TobyCornish]

We are now proposing a follow-up using the Sphere's 160,000 sq ft interior LED display — essentially a very large, very expensive reading room. It eliminates both the ambient light and HIPAA concerns, with the welcome addition of air-conditioning. 9/

[Toby C. Cornish MD, PhD @TobyCornish]

Ambient lighting remains a challenge for daytime use. Las Vegas averages 294 sunny days/year.

"The medical community solved the ambient light problem by putting pathologists in a windowless basement. We considered this, but it's hard to put a 366-ft sphere in a basement." 8/

[Toby C. Cornish MD, PhD @TobyCornish]

At the standard Sphere advertising rate of $450,000/day, this represents the most expensive telepathology consultation in history — though still cheaper than an out-of-network second opinion.

We are now marketing Strip-facing hotel rooms as "remote sign-out suites." 6/

[Toby C. Cornish MD, PhD @TobyCornish]

A board-certified pathologist at The Venetian identified the case as a neuroendocrine tumor from her 34th-floor window.

She texted us "did you order a MIB-1?" at 11:47 PM.

That's telepathology without a network, without a viewer, without even a computer. 5/

[Toby C. Cornish MD, PhD @TobyCornish]

"We didn't need Zoom or other technologies to share our screen," said Cornish. "Anyone within a two-mile radius and a clear line of sight was already looking at it."

Review time: 1 hour 15 minutes, including a 25-minute intermission for nachos. 4/

[Toby C. Cornish MD, PhD @TobyCornish]

We drew inspiration from the Leeds Powerwall, but "Why stop at 37 square feet when you could have 580,000?" — Dr. McClintock, gesturing toward the 366-foot-tall rendering of a well-differentiated neuroendocrine tumor glowing above the Las Vegas skyline.

[Toby C. Cornish MD, PhD @TobyCornish]

The demonstration featured a pancreatic neuroendocrine tumor rendered across the Sphere's 1.2 million LED pucks — approximately 13.3 acres of histopathology. The WSI was visible to an estimated 300,000 nightly visitors. Navigation via PlayStation DualSense controller. 2/

[API - pathbytes @pathbytes]

API Is Expanding Its Global Reach!🌐

New Initiatives Increase Access, Opportunity, and Equity Worldwide— The Association for Pathology Informatics (API) today announced the expansion of its global initiatives

Full release: https://t.co/dtPZMlWbSq

#pathology #informatics #ai

[Toby C. Cornish MD, PhD @TobyCornish]

Randomly, a new YouTube video on #MUMPS https://t.co/q61kWtiTui

[Toby C. Cornish MD, PhD @TobyCornish]

@nickspies and Chris Garcia discuss how Mayo labs and ARUP labs monitor AI applications post implementation @pathbytes #PV2025

[Toby C. Cornish MD, PhD @TobyCornish]

I just had a conversation with a live @amazon customer service rep, which made me wish I was talking to ChatGPT instead

[Toby C. Cornish MD, PhD @TobyCornish]

How well do foundation models predict outcomes in out of distribution cancer types? look for an upcoming publication from Jana Lipkova #HIMA #PISummit2025 @pathbytes

[Toby C. Cornish MD, PhD @TobyCornish]

Orange, TeachableMachine, fastai, TIMM, and other tools offer an approachable on ramp for machine learning in pathology. Jerome Cheng @UMichPath at #HIMA #PISummit2025 @pathbytes

[Toby C. Cornish MD, PhD @TobyCornish]

Agentic AI might power tumor boards as part of generative AI powered next-gen precision heath. @hoifungpoon at #HIMA #PISummit2025 @pathbytes