Debbie Toiber

Molecular Biologist, DNA repair, sirtuins, ageing and Neurodegeneration

[Debbie Toiber @ToiberDebbie]

SPARK-ID: Dynamic DSB-sensor interactomes reveal modular nuclear repair networks coordinated by connector proteins https://t.co/Yk1ZJGAb5F

[Debbie Toiber @ToiberDebbie]

As an example we deepen our understanding on NCL as an important gatekeeper. So much work so much information as a resource, just read the preprint and play withe the network website, that is in beta mode: https://t.co/t5Wbvu2quq

[Debbie Toiber @ToiberDebbie]

Alfredo is one of the most talented people I have worked with; he created this amazing resource. It will help us understand how the cell coordinates the DSB response depending on the dynamic interactome of the sensor (HR, NHEJ), give us insight into the topological organization

[Debbie Toiber @ToiberDebbie]

Some overlapping interactomes of SIRT6, MRE11, and KU80 reveal a conserved repair core alongside sensor-specific specialisation. The shared core functions, combined with distinct individual proteins, make the system robust, reducing the DDR's dependence on any single protein

[Debbie Toiber @ToiberDebbie]

Genluminati, a novel, is free for 3 days! https://t.co/KRcYK07bx6

[Debbie Toiber @ToiberDebbie]

https://t.co/FwDtwu9aO6

[Debbie Toiber @ToiberDebbie]

Why'd you have to go and make things so complicated? Simplicity as a Lens: A New Way to Model Brain Aging. https://t.co/fzBVbI4uKu our latest preprint! #AgingResearch #Neuroscience #Alzheimers #SIRT6 #biotech

[Debbie Toiber @ToiberDebbie]

Congratulations to Yuval, the leading author, and all our collaborators: Dmitrii Smirnov, Songchen Yang, Daniel Stein, Zeev Slobodnik,
@EremenkoEkater2
Shai Kaluski-Kopach, Monica Einav, and Ekaterina Khrameeva

[Debbie Toiber @ToiberDebbie]

Congratulations to Yuval, the leading author, and all our collaborators: Dmitrii Smirnov, Songchen Yang, Daniel Stein, Zeev Slobodnik, @EremenkoEkater2 Shai Kaluski-Kopach, Monica Einav, and Ekaterina Khrameeva

[Debbie Toiber @ToiberDebbie]

Why'd you have to go and make things so complicated?

Simplicity as a Lens: A New Way to Model Brain Aging.
https://t.co/FwDtwu9aO6
See our latest preprint!
#AgingResearch #Neuroscience #Alzheimers #SIRT6 #BioTech

[Debbie Toiber @ToiberDebbie]

SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling - Stein - 2026 - Aging Cell - Wiley Online Library https://t.co/D7NTbR8fF9

[Literary Titan @LiteraryTitan]

Genluminati follows a group of young scientists who invent a DNA-based religion as a cynical experiment—only to lose control of it when belief spreads, and a prophet emerges. Did the concept begin as #satire for you, or did you always see it turning dark?
https://t.co/Oa44sVZwM1

[Debbie Toiber @ToiberDebbie]

Check out this book recommendation from Literary_Titan: https://t.co/ICBmmxz38O via @Bookbub

[Ben-Gurion University of the Negev @bengurionu]

🟠 For the full article>>
https://t.co/PeTzCsJYO6

[Debbie Toiber @ToiberDebbie]

This positions SIRT6 as a critical, upstream drug target for combating neurodegenerative pathology.
Amazing work by Shai Kaluski-Kopatch, and collaborators

[Debbie Toiber @ToiberDebbie]

SIRT6 decline throws Off Mood, Sleep, and Cognition.
https://t.co/3NSXGGoisF
Tryptophan byproducts build proteins, NAD+, and neurotransmitters (serotonin and melatonin). Yet, in aging and neurological disease, this balance is lost, leading to impaired mood, learning, and sleep.

[Debbie Toiber @ToiberDebbie]

Crucially, we show that this damage isn't permanent. By inhibiting the enzyme TDO2 in our SIRT6 knockout fly model, we were able to significantly reverse both neuromotor decline and vacuolar formation, indicating a powerful therapeutic window.

[Debbie Toiber @ToiberDebbie]

@BarakRotblat just in case someone wants to join: https://t.co/KRcYK07bx6