Thomas Cardaci

Research Fellow, Postdoc | PhD, MS, CSCS*D | Cancer, Muscle Biology, & Exercise | Colorado State University | CU Anschutz SOM | USC SOM, Rutgers & Baylor Alumni

[Thomas Cardaci @TomCardaci]

Decellularized some muscle for SEM analysis of the extracellular matrix.

I think it came out pretty sick!!

#myotwitter

[Thomas Cardaci @TomCardaci]

7️⃣
🧩 Take-home:
Muscle fibrosis is not a consequence of tumor presence but a distinct pathological feature of cancer cachexia.
Cachexia promotes a profibrotic microenvironment, where immune cells + FAPs contribute to ECM remodeling and worsen muscle dysfunction beyond atrophy.

[Thomas Cardaci @TomCardaci]

Excited to share our recent paper “Pro-Fibrotic Immune Cells & FAPs Contribute to Skeletal Muscle ECM Remodeling and Fibrosis in Cancer Cachexia”

🧵 Summary of our findings below.

👇

https://t.co/Z92HZWnauL

@b_veen17 @UofSCSOMC @UofSC @AJPCellPhys @USCResearch #myotwitter

[Thomas Cardaci @TomCardaci]

6️⃣
Gene expression analysis further supports this profibrotic and altered immune microenvironment:
⬆️ TGF-β, HIF-1α, IL-6, Nos2
⬆️ Collagens (Col1, Col5), Fn1, MMP2
➡️ Cachectic muscle = active fibrogenic + inflammatory signaling.

[AJP-Cell Physiology @AJPCellPhys]

There's new #fibrosis info in this #ArticleinPress, Pro-Fibrotic Immune Cells and Fibro-Adipogenic Progenitors Contribute to Skeletal Muscle Extracellular Matrix Remodeling and Fibrosis in Cancer Cachexia (Thomas D. Cardaci et al. @UofSCSOMC):

https://t.co/l1WTMtMspp

[AJP-Endocrinology and Metabolism @AJPEndoMetab]

From talented teams at @UofU3i and @UofUPT comes today's impressive #ArticleinPress. #Macrophage Immunometabolism - Emerging Targets for Regrowth in #Aging #Muscle (Zachary Fennel et al.):

https://t.co/PVs6s6ge68

[Exercise, Sport, and Movement @ESM_ACSM]

New graphical review now published! 🚨 Mechanistic Insight into Physical Activity Pleiotropy in Cancer Prevention

Read it here: https://t.co/0WhBmDZzBS

#Exercise #Sport #Movement #ACSM #ExerciseOncology #PhysicalActivity #CancerPrevention

[Exercise, Sport, and Movement @ESM_ACSM]

New Article Alert! ✨

Multisymptom Burden in Cancer Survivors: Benefits of Physical Activity

Find it here: https://t.co/T1ElD0i9ZT

#Exercise #Sport #Movement #ACSM #ExerciseOncology #PhysicalActivity #Cancer

[Exercise, Sport, and Movement @ESM_ACSM]

The wide-ranging benefits of #PhysicalActivity and structured exercise offer a strong case for their role in reducing the negative effects of cancer and its treatments.

Learn more: https://t.co/pNgIDlSXqb

#Exercise #Sport #Movement #ExerciseOncology #Cancer

[Dr Ai Lyn Tan @DrAiLynTan]

#PhysicalActivity #exercise can reduce #cancer risk

✅Control weight
✅Improve immune & inflammatory profile
✅Enhance colonic environment
✅Regulate sex hormone levels

👉🏽https://t.co/ign2VkIRdd
via @ESM_ACSM

[Jeffery L. Heileson, PhD, RD @jheilesonPhD]

🚨🚨I’ll be speaking at the ISSN Tactical Summit on November 2, 2024 organized by @FireRescueWell and Drew Gonzalez

There is a fantastic line up of speakers, to include @drmyohead, @AJagim, @BM_Roberts_SkM, @DrJayDawes, @DrBobLockie, @DrCreatine, @FittoEnforcecom

[AJP-Cell Physiology @AJPCellPhys]

Today's #ArticleinPress is an APS Select article! Decreased skeletal muscle intramyocellular #lipid droplet-mitochondrial contact contributes to myosteatosis in #cancer cachexia (Thomas Cardaci et al. @UofSC):

https://t.co/sAybkmcxZW

[AJP-Cell Physiology @AJPCellPhys]

Congratulations! Thank you @TomCardaci for publishing with #AJPCell!

[Thomas Cardaci @TomCardaci]

@AJPCellPhysEIC Thank you! Much appreciated!

[Thomas Cardaci @TomCardaci]

What a great way to end the week! Thanks for selecting our paper as an #APSselect paper!

[APS Publications @APSPublications]

Congrats to Thomas D. Cardaci et al. for the #APSselect paper "Decreased skeletal muscle intramyocellular lipid droplet-mitochondrial contact contributes to myosteatosis in cancer cachexia" in @ajpcellphys
@TomCardaci @UofSCSOMC

https://t.co/fTVWn5WDMs

[Thomas Cardaci @TomCardaci]

@runnergirladams Thanks Michelle!