Tom Julian

Manchester Royal Eye Hospital Ophthalmology resident
University of Manchester PhD student, studying disease prediction using retinal images.

[Tom Julian @TomJulian18]

Congratulations to Arni Sarian and Zain Girach on their review published this week examining ophthalmic features associated with stroke. The paper synthesises evidence linking stroke to a broad spectrum of retinal vascular and neuro-retinal changes.

https://t.co/yI3C0Wk5Mw

[Tom Julian @TomJulian18]

Scans of the eye have been used to identify who is at risk of disease of the brain and cardiovascular system - but what links the eye to broader health? And what is the full spectrum of predicable disease? We aim to answer these questions here:
https://t.co/h9pdEX8Nfz

[Tom Julian @TomJulian18]

Thank you to my colleagues Panos, Ewan and Tom, who supported me in this exploration of the genetic architecture of the pigmented tissue of the retina and it's relationship to other pigmented traits:
https://t.co/fMsiQwScVc

[Tom Julian @TomJulian18]

The fovea is responsible for high acuity vision. What are the genetic determinants of foveal morphology ? And how does foveal morphology relate to future risk of sight threatening disease? Nice work led by David and Panos exploring these questions: https://t.co/rbJnG6qFkM

[Tom Julian @TomJulian18]

Great work from my colleagues at SITraN, who are building on our understanding of how exercise affects motor neurone disease risk: https://t.co/gIr8TD3Fqy

[Tom Julian @TomJulian18]

The 'retinal pigment epithelium' (RPE) is a pigmented layer in the eye that differs from other pigmented tissues in terms of it's origins and biology. Here, we have studied how closely RPE thickness is related to the colour of the skin, hair, and eye: https://t.co/rDoKNfEdQd

[Jim Pickard 🐋 @PickardJE]

thought I’d share this golden clip while everyone is aimlessly waiting

[Tom Julian @TomJulian18]

Great work led by Elham Alhathli, exploring causal relationships between serum metabolites and pulmonary arterial hypertension using Mendelian randomisation, with complementary rare variant burden testing.

https://t.co/WkyYwOeZhs

[Tom Julian @TomJulian18]

The retina is the only structure where the microvasculature and CNS can be directly and non-invasively visualised. Retinal imaging has great potential as a screening tool for stroke risk, and for risk of cardiovascular disease more broadly.

https://t.co/WoZYiM6huO

[Tom Julian @TomJulian18]

Interesting work led by the team at SITraN exploring the role of mitochondrial function in the severity of ALS/MND:
https://t.co/3IwFTE7QeQ

[Tom Julian @TomJulian18]

Primary open angle glaucoma (POAG) is a condition with few known risk factors, and only one treatment target (reducing IOP). We have screened for causal relationships between POAG and 9,661 traits. See the results here: https://t.co/YkUX7NazuP

[Tom Julian @TomJulian18]

@MehnoorKhaliq Yeahhhh budddayyyyy

[Led By Donkeys @ByDonkeys]

🚨MPs FOR HIRE: a Led By Donkeys undercover investigation🚨

Watch the trailer…

[Tom Julian @TomJulian18]

5/ Thank you to everyone who worked hard on the project!

[Tom Julian @TomJulian18]

1/ Very pleased with this one! Mendelian randomisation (MR) is a technique which uses genetic variation to look for causal relationships between exposures (such as smoking) and outcomes (such as risk of a specific disease). https://t.co/vrnz7PNLpX

[Tom Julian @TomJulian18]

4/ We hope our work can provide direction for future research focussing on the prevention of AMD, or even AMD treatments. Our phenome-wide MR pipeline could be replicated for any trait of interest to enable hypothesis-free analysis of causal and protective factors in disease.

[Tom Julian @TomJulian18]

There are few modifiable risk factors for POAG. Our study identified several interesting protective and causal environmental factors related to POAG risk.

https://t.co/DFcZ1YpTVx

[Tom Julian @TomJulian18]

MR work demonstrating a relationship between serum urate and neurodegeneration. Specifically, we show that serum urate is a causal factor for Alzheimers disease.
https://t.co/SVM1Z78nQ1