Triptesh Kumar Roy

Ph.D. student @ritter_lab @maxplanckpress. BS-MS @IiserTirupati, MS thesis @dm_lab @iitbombay

[Hall Research Group at UAlberta @HallBoronLab]

This week's Paper-of-the-Week (POW) presentations in our weekly group meeting featured some great work by @GouverneurGroup + @LloydJonesLab, Willis Group, and @ritter_lab! #chemistry

[nature @Nature]

Nature research paper: Decarboxylative alkylation of alkenes

https://t.co/ML69TNEbQl

[Triptesh Kumar Roy @TripteshR]

@ChinmoyKHazra1 @ChandrikaGhos19 @Nature Thank you very much

[Triptesh Kumar Roy @TripteshR]

Our work on decarboxylative alkylation of alkene is now online in @nature

[Ritter Lab @ritter_lab]

In @Nature, we show that redox-active esters can be transformed into alkyl zinc species useful for transmetalation, providing a solution to rate matching in XEC reactions! First application: alkylation of alkenes via polar decarboxylative cross-coupling!

https://t.co/mOBf4ChHk0

[Triptesh Kumar Roy @TripteshR]

@mato_mauro @g_laudadio @Nature We did not really try to see can we use it as a general electrophile to form organometallic species. But It can be a good idea to look in to that aspect.

[Triptesh Kumar Roy @TripteshR]

@mato_mauro @g_laudadio @Nature Hi Mauro, thanks. Alkenyl-TT is easy to reduce. Even with zinc we can see slow reduction. Using metals with lower reduction potential (Mg/Li) is not so helpful in that way, also alkylzincs are more tolerating towards many functional groups, and suitable for transmetallation step.

[Ritter Lab @ritter_lab]

Our alkene alkylation strategy has been featured in @cenmag!

https://t.co/V9k1JJKzJj

[Triptesh Kumar Roy @TripteshR]

@Teja_Chitrala Thank you Teja anna

[Triptesh Kumar Roy @TripteshR]

@itsAD09 @Nature Thank you

[Triptesh Kumar Roy @TripteshR]

@SayanRoy16 @Nature Thank you sayan da

[Triptesh Kumar Roy @TripteshR]

@ArkaSinha14 @ritter_lab @Nature Thank you Arka

[Triptesh Kumar Roy @TripteshR]

@rachit4499 @Nature Thank you Rachit

[Triptesh Kumar Roy @TripteshR]

@WaskeShivam @Nature Thank you Shivam

[Triptesh Kumar Roy @TripteshR]

@i_am_mangish @ritter_lab @Nature Thank you Mangosh

[Triptesh Kumar Roy @TripteshR]

@i_am_mangish @ritter_lab @Nature Thank you Mangish

[Triptesh Kumar Roy @TripteshR]

@g_laudadio @Nature But if you use Pd/Zn system Pd(0) or Pd(II) is less likely to hamper RAE. Zn is going to reduce RAE. So there is a high possibility of observing alkylzinc species in polar aprotic solvent.

[Triptesh Kumar Roy @TripteshR]

@g_laudadio @Nature Hi Gabriele, I think when Ni/Zn system is used for general C(sp2)-C(sp3) XEC, it proceeds through radical pathway. Ni(I) reduces RAE at a much faster rate than metallic zinc. So probably alkyl radical (or alkyl-Ni, after ligation) is key there.

[Ritter Lab @ritter_lab]

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[Ritter Lab @ritter_lab]

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[Ritter Lab @ritter_lab]

New method for N-arylation of amines in DNA-encoded libraries! Using ruthenium-mediated pi-arene activation, aryl halides are activated, then undergo SNAr followed by photolysis to give the N-arylated DNA-conjugate.

Out now in @J_A_C_S ! Open Access🔓

https://t.co/G6usOSeAS0