Kiro — GLP-1 Body Recomp

I'll get smaller, but I'll also get weaker, older looking, and more deplete.Lose the fat. Keep the muscle. Look great on GLP-1. Free muscle loss risk assessment

[Kiro — GLP-1 Body Recomp @TryGetKiro]

40% of weight lost on GLP-1 drugs is muscle, not fat.

That's ~6.9 kg of lean mass gone in 68 weeks (STEP 1 trial, NEJM).

We built a free assessment that scores your muscle loss risk in 60 seconds — based on 5 clinical risk factors.

→ https://t.co/8Vm2xekf2x

[Dr. Gabrielle Lyon @drgabriellelyon]

The obsession with weight loss is one of the most clinically misguided frameworks in modern health. Skeletal muscle regulates glucose, drives metabolism, protects bone density, and determines functional capacity across the lifespan. Losing weight without preserving lean mass does not improve health outcomes. It accelerates metabolic fragility. The number on the scale has never been a measure of physiological resilience. Muscle is. Build the tissue that matters.

[Dr. Gabrielle Lyon @drgabriellelyon]

The fear of getting bulky is one of the most persistent myths keeping women out of the weight room, and it has no physiological basis. Women do not have the hormonal profile to produce that outcome without extreme and deliberate effort. What resistance training produces is stronger lean mass, improved metabolic health, and long-term functional capacity. Liz Plosser and I covered this directly: women have been loading their bodies their entire lives, toddlers, luggage, groceries, without a structured program. The only missing variable is intention. The body already knows how to move under load. The goal now is to do it with structure.

WATCH HERE: https://t.co/xtRPe8s0Ce

[Kiro — GLP-1 Body Recomp @TryGetKiro]

Honest question for anyone currently on a GLP-1 — what % of your weight loss do you think was actually muscle vs fat?

Curious where people land before they see the data 👇

[Kiro — GLP-1 Body Recomp @TryGetKiro]

GLP-1 works.
But up to 30% of the weight you lose isn't fat — it's muscle.
Here's what peer-reviewed research actually says about doing it right (and what TikTok won't tell you)

[Kiro — GLP-1 Body Recomp @TryGetKiro]

4/ This is why we built Kiro.

A GLP-1 AI companion built on peer-reviewed research — not TikTok tips, not influencer guesses, not Reddit threads.

We don't guess. We cite.

Join the waitlist 👉 https://t.co/gaJ9ea1DWL

[Kiro — GLP-1 Body Recomp @TryGetKiro]

3/ Resistance training is non-negotiable.

Nutrients, 2018: Resistance training protects 93.5% of lean muscle mass during caloric deficit.

Cardio burns calories. Lifting protects the body underneath.

[Kiro — GLP-1 Body Recomp @TryGetKiro]

Up to 40% of the weight you lose on GLP-1 medication can be muscle.
Not fat. Muscle.
And your doctor is celebrating the number on the scale.

[Kiro — GLP-1 Body Recomp @TryGetKiro]

What your doctor gives you when you start Ozempic:

+ A prescription

+ A follow-up in 3 months

+ "Make sure you get enough protein"

What you actually need:

+ A protein plan that works with zero appetite

+ A workout built for fatigue

+ A hair loss protocol

+ Someone who's been through it

That's the GLP-1 Body Protocol. 57 pages. Built for you.
https://t.co/3pL2bJHbQo

[Kiro — GLP-1 Body Recomp @TryGetKiro]

I was losing weight on Ozempic.

I was also losing my hair. My muscle. My energy.

My doctor said: "Keep it up, the scale looks great."

I built Kiro because no app, no doctor, no guide existed for what I was actually going through.

https://t.co/rYs4fJ27Do free early access, open now.

[Crémieux @cremieuxrecueil]

Three new papers on weight loss maintenance just dropped!🧵

The first found that people could maintain most of their weight loss after tirzepatide by just using a much lower dose:

[Michael Weintraub, MD @MWeintraubMD]

GLP-1s effectiveness at blood pressure control on par with traditional anti-hypertensives, tracks well with % weight loss

[Kiro — GLP-1 Body Recomp @TryGetKiro]

Here's what actually separates people who succeed vs. quit:

❌ Quitters wait to feel motivated
✅ Keepers follow a protocol

❌ Quitters track nothing
✅ Keepers track everything that matters

❌ Quitters have no community
✅ Keepers have accountability

GLP-1 is a tool. Not a magic switch.

[Michael Weintraub, MD @MWeintraubMD]

What are the benefits and harms of GLP-1s in older adults? 🤔

It's challenging to answer this question because most randomized controlled trials did not include large numbers of older adults.

📊 In a meta-analysis of older adults from 11 RCTs with 85,373 individuals who either received GLP-1 or no GLP-1:

⬇️ GLP-1 RA with 15% reduction in MACE (CV death, stroke, MI) 🫀
⬇️ 22% reduction in kidney composite outcome

[Kiro — GLP-1 Body Recomp @TryGetKiro]

50% of GLP-1 users quit within 12 months.

Not because the drug stopped working.
Because no one prepared them for:

The "ugly middle" plateau (weeks 8-16)
Injection site fatigue
Muscle loss if protein timing is wrong
Rebound hunger signals

The drug is the easy part.

[Kiro — GLP-1 Body Recomp @TryGetKiro]

Your doctor spent 8 minutes prescribing your GLP-1.

Nobody told you what happens at week 6.
Nobody warned you about the plateau.
Nobody explained why cravings come back at month 4.

That's not a drug problem.
That's a support problem.

🧵 What no one tells you about staying on GLP-1 long-term:

[Kiro — GLP-1 Body Recomp @TryGetKiro]

@drgabriellelyon Spot on!
This pilot study (Minerva Endocrinol 2026, DOI: 10.23736/S2724-6507.26.04541-0) is exactly what we needed: in hypogonadal obese “late responders” on tirzepatide, adding testosterone undecanoate gave superior fat loss, greater total weight loss, and restored lean mass while the tirzepatide-only group kept losing muscle.
Perfect illustration of Dulloo’s collateral fattening (PMID 29559726): lose muscle biological drive to regain mostly fat.
Protein (1.6–2.2 g/kg) + resistance training remain non-negotiable for everyone on GLP-1s.
Personalized, multimodal obesity care is the future.