I'm excited to report that our FGFR4-targeting ADC work is now published! This is the most advanced program in development that uses our legumain-cleavable Top1i technology.
An exciting month in the Tumey lab! I have an incredible group of students and staff that made this possible - and an amazing department at Binghamton University!
https://t.co/RFe3KYaoG5
The adoption of ADC technology outside of oncology will almost certainly require subcutaneous (SQ) administration. In the below article, we describe the current state of the field - describing both the promise and the challenges of developing SQ formulations.
I’m excited to share our most recent publication describing the development of non-glycosylated (Fc-silent) immune stimulating antibody conjugates (NG-ISACs) for the treatment of TROP2-positive cancers.
Immune-stimulating antibody conjugates (ISACs) are gaining traction! I’m excited to share the full story of our exploration of the role of FcγR’s in the design of TLR7-based ISACs.
Binghamton University is Tackling Childhood Cancer
We are developing a targeted drug delivery system to treat rare childhood cancers—bringing hope for safer, more effective therapies.
@TumeyGroup reports a native site-specific method to attach drugs at the Q295 site of mabs. Using TPPMS and a resin-supported strategy, they created uniform and stable Antibody-drug Conjugates (ADCs). #bioconjugation, #ADCs, #Cancer https://t.co/G9ZCxyhHb1
🧬 I'm taking part in an NSF I-Corps program to explore market needs for immune-modulating therapies. Looking to speak with 10–15 folks involved in treating autoimmune diseases or developing related drugs. If you're up for a quick 10–15 min chat, DM me or drop a comment. Thanks!
@binghamtonu, @BingPharmacy, @TumeyGroup, Researching the researchers: A look into the school of pharmacy’s post-doctoral program https://t.co/jLQQsU7rof