John

'Success is not final, failure is not fatal: it is the courage to continue that counts'

[William Makis @MakisMedicine]

NEW ARTICLE: RESEARCH: NICLOSAMIDE in CANCER and other diseases - 2025 Review Paper from Henan, China

NICLOSAMIDE was approved by FDA in 1982 for treating tapeworm infections, and was designated an essential drug by WHO.

NICLOSAMIDE in CANCER Mechanisms:

1. Mitochondrial uncoupling - this is its major anti-cancer mechanism

Niclosamide acts like a mild “leak” in the mitochondrial membrane, letting protons slip across without making ATP. This increases oxygen use, lowers ATP levels, raises AMP/ATP ratio & activates AMPK (energy sensor) to inhibit mTOR (slows down cancer cell growth).

Cancer cells, which often rely on inefficient energy pathways (Warburg effect), are especially vulnerable.

This can lead to inhibition of ATP synthesis, exhausting cellular energy reserves, metabolic stress, and cell death.

2. Signal pathway modulation - It inhibits several “pro-cancer” pathways, including:

- Wnt/β-catenin (important in cancer proliferation, especially colorectal).
- mTOR (controls cell proliferation, growth and metabolism).
- Notch pathway (controls proliferation, growth, angiogenesis and cellular migration)
- STAT3, NF-κB, etc. (cancer survival, proliferation).
- Promotes apoptosis (programmed cell death) and reduce inflammation.

3. Combination with existing chemotherapies

4. Addresses Multi-Drug Resistance - by enhancing production of reactive oxygen species.

OTHER DISEASES - beyond cancer, Niclosamide’s versatility includes:

Anti-bacterial - strong in vitro activity against resistant gram-positive bacteria.

its antibacterial activity involves altering bacterial morphology, reducing intracellular ATP, and inhibiting α-HL secretion (Staph Aureus)

it inhibits all three toxins of Clostridium difficile by targeting a host process essential for toxin entry into colonocytes. In a mouse model, it reduced both primary disease and recurrence without affecting gut microbiota diversity

it demonstrates marked inhibition of vancomycin-resistant Enterococcus faecium (VRE)

It effectively eliminates H. pylori adhesion/invasion

Anti-Fungal - demonstrates impressive antifungal effects in vitro and in vivo niclosamide effectively disrupted and removed biofilms of drug-resistant Candida albicans and Candida auris by targeting mitochondrial respiration

Anti-Viral - Niclosamide could have action against SARS-CoV, MERS, Zika, Hepatitis C, Ebola, EBV

Niclosamide inhibits viral replication by reducing mTOR activation and prevents viral entry

inhibits virion production in EBV-infected cells while showing cytotoxicity and inducing cell cycle arrest

demonstrates strong activity against RSV in vitro, with a 94 % inhibition rate

suppresses Hepatitis C replication and reduces viral load

Metabolic disorders (e.g., Type II Diabetes, fatty liver): Mitochondrial effects and AMPK activation can improve energy balance and reduce fat accumulation.

Diabetes: modulates metabolic pathways, improves insulin sensitivity

Fatty liver (NASH, NAFLD) - reduces hepatic inflammation

Neuropathic Pain - reduces inflammation by inhibiting NF-kB, STAT3

alleviates pain and nerve damage

Rheumatoid Arthritis - inhibits NF-kB activation
reduces secretion of IL-6 and other inflammatory cytokines,

blocks migration and invasion of RA fibroblast-like synoviocytes.

Psoriasis - inhibits keratinocyte hyperproliferation and reduces inflammation by downregulation of STAT3, NF-kB.

Airway Diseases (Asthma, Cystic Fibrosis, COPD)

Niclosamide inhibits certain Ca-activated Cl channels involved in mucus hypersecretion & bronchoconstriction (reduces mucus production & secretion.

it blocks release of mucus and inflammatory mediators which reduces bronchoconstriction.

anti-fibrotic agent for lung fibrosis - Niclosamide downregulates expression of collagen proteins and inhibits pro-fibrotic cytokines.

Endometriosis - Niclosamide targets STAT3 and NF-kB, reduces proinflammatory cytokines and reduces endometriotic lesion growth.

ALS
In vivo experimentation involving two ALS mouse models demonstrated slowed disease progression, enhanced survival rates, and reduced motor neuron loss and muscle atrophy.

At the molecular level, niclosamide inhibited dysregulated pathways such as STAT3 and mTOR, reduced gliosis, and dampened inflammatory signaling

niclosamide has shown remarkable potential by efficiently inhibiting the expression of S100A4, a Ca2+-binding protein frequently upregulated in reactive microglia and astrocytes in ALS models. This inhibition contributes to reduced microglial reactivity, cytoskeletal changes & inflammation in ALS

Systemic Sclerosis - inhibits STAT3, AKT, and Wnt/β-catenin pathways

reduced immune cell activation

reversal of skin and lung fibrosis and reduced rate of inflammation

CONCLUSION:

Ivermectin, Mebendazole and Fenbendazole are leading the repurposed drug revolution

but Niclosamide is the most promising of the other anti-parasitics!

[Enezator @Enezator]

Wtf Lol

https://t.co/U5tL2fLsaB

[Globe Eye News @GlobeEyeNews]

BREAKING:

U.S. Department of Homeland Security requests Google, Reddit, Instagram, and Facebook to provide names, phone numbers, and other identifying information of users who criticize ICE.

[Stefan Moore ★ @2StefanMoore]

A leading force in cancer innovation is making real strides. Dr. Patrick Soon-Shiong & ImmunityBio are powering ahead with Anktiva, a groundbreaking IL-15 superagonist immunotherapy that activates & multiplies the body’s natural killer (NK) cells & memory T cells to precisely hunt down & destroy tumors.

Instead of harsh chemo that damages healthy cells & weakens immunity, Anktiva restores & strengthens the immune system for targeted, longer lasting attacks, offering hope for fewer side effects & better outcomes.

The visionary behind it,@DrPatrick, surgeon, inventor & ImmunityBio’s Founder, Executive Chairman & Global Chief Scientific Officer.

Anktiva earned U.S. FDA approval in 2024 for BCG unresponsive non muscle invasive #BladderCancer (NMIBC) with carcinoma in situ. In January 2026, the Saudi FDA granted accelerated approvals for:
• Anktiva + checkpoint inhibitors in metastatic non small cell #LungCancer (a world first for subcutaneous IL-15 therapy!)
• #Anktiva + BCG in BCG
unresponsive NMIBC

Plus, strong trial data show immune restoration, prolonged survival in tough cases & promising signals in lung, pancreatic, glioblastoma & more.

Sales are surging too. ImmunityBio reported ~$113 million in preliminary 2025 net product revenue, a massive 700% year over year jump!

Experts stay cautiously optimistic. More trials & approvals needed, but this “Immunotherapy 2.0” shift empowering the body’s natural defenses is changing the game toward smarter, kinder cancer care.

Hope is building as science advances. The future of fighting #cancer looks brighter every day.

[HustleBitch @HustleBitch_]

🚨 THE CURE FOR CANCER HAS JUST BEEN APPROVED - BUT NOT FOR AMERICANS

Dr. Patrick Soon-Shiong went on air with Chris Cuomo and dropped a claim that should’ve stopped the country cold.

He says a universal cancer treatment - shown to extend survival in lung, breast, pancreatic, and even glioblastoma - already exists. The molecule (IL-15) was flagged over a decade ago as one of the most promising cancer-killing candidates ever. The trials exist. The survival data exists.

According to him, Saudi Arabia reviewed the science and approved it for lung cancer, while in the U.S., the exact same drug is still restricted to a tiny bladder-cancer use.
More than 13,000 patients are now reportedly requesting access.

Same drug.
Same data.
Different outcome.

If this can save lives, who decided Americans don’t deserve it yet?

[HustleBitch @HustleBitch_]

🚨 HE POINTED HIS TELESCOPE AT THE MOON - WHAT HE CAPTURED NEXT SHOCKED HIM

Clouds were rolling in, but for a few seconds, the sky opened.

He aimed his telescope just below the Moon - “Whoa, okay… there’s Saturn!”
You can see Titan and three other moons orbiting around it, with Saturn’s rings almost invisible as they turn edge-on this month.

“It really feels like November,” he says. “Didn’t expect that tonight.”

A rare break in the clouds. One perfect moment. The universe showing off.

[Azat @AzatAlsalim]

Nigerian man gives his testimony after the massacre of his village: "all the houses were set on fire and all our grain was burned. This morning we buried 29 people". Why is no one protesting for them?

[HealthRanger @HealthRanger]

I have a disturbing update on the Barium fallout from chemtrails and “weird fog” events. In our mass spec lab, using ICP-MS analysis, we are seeing Barium-137 at estimated levels exceeding 150 ppm (semi-quant scan via ICP-MS, and we are now acquiring external standards to run full quant on this element in the near future) is Barium-137, which means it has an atomic mass of 137. This isotope of Barium is known to be largely created by the beta decay of Cesium-137, which is a highly radioactive “death powder” that’s used in dirty bombs and is one of the byproducts of nuclear detonations. As Cs-137 decays (half life of approx. 30 years), the beta decay transmutes Cs-137 into Ba-137 (through another interim step of Ba-137m). It is this Ba-137 that we are detecting in the chemtrails fallout sample provided by @RealDrJaneRuby, and we are seeing it at alarmingly high levels. Even higher than the lead and cadmium also found on the same sample. What this means is that the Barium falling out of the sky in Florida could be, in part, the result of decayed Cs-137 from previous nuclear tests. Literally, this could be actual nuclear waste transmutation products being dropped from the sky, perhaps as a way to just get rid of them, or perhaps as a way to harm the population with latent radiation that’s still present. Since we are not a radiation lab, I’m not able to test for radiation in a comprehensive, ISO-accredited way, but I would certainly hope that somewhere in Florida, there would be radiation detectors that would sound the alarm of high levels of radioisotopes started falling from the sky. I’m not claiming there’s a radiation emergency right now, but somebody should check just to make sure. Then again, in Fukushima, they just TURNED OFF ALL THE DETECTORS and said everything was safe. So who knows… What I’m saying for sure is that we are counting Barium-137 elements in very high numbers in the Jane Ruby sample from Florida, and I do not know where all this Barium-137 might be coming from, but I am incredibly concerned about the picture emerging here. What sort of chemtrails fallout contains Mercury, Lead, Cadmium, Aluminum, Copper, Nickel and also Barium-137 (likely derived from Cesium-137 at some point)? This mystery just gets more disturbing by the day… And why does NOBODY from the Florida state government, nor the U.S. government, seem interested in getting to the bottom of this? ICP-MS is the most reliable mass spec test you can run. When I say we are seeing Barium-137 elements, that’s an irrefutable fact. We have the counts (CPS) on the detector, and we have all the logs, the calibration curves for the other masses, the saved samples archived, etc. I’ll keep sharing reports as we learn more.

[Vani Hari @thefoodbabe]

Wonder why obesity, allergies, and inflammatory diseases are on the rise? A new scientific review implicates several processed food additives:
Cellulose
Lecithins
Carrageenan
Guar Gum
Xanthan Gum
Polysorbate 20
Polysorbate 80

[Wall Street Apes @WallStreetApes]

American shows there’s a “Toxic paint cleaner ingredient found in Cinnamon Toast Crunch”

He heads to Home Deport to show you the same ingredient

Here’s where it gets crazy, it’s so toxic to humans its been pulled from the shelf and has to be ordered online

It’s still in cereal

[FLAT OUT TRUTH @TheFlatEartherr]

Is anyone interested in watching The Book of Enoch the movie? 🍿 If so, I'll get it uploaded to Rumble today!

[Pierre Kory, MD MPA @PierreKory]

A woman facing a lung transplant reversed her condition with a $30 over-the-counter treatment.
Doctors told her she had no options. A new doctor suggested DMSO.
Months later? Her lungs were CLEAR.
Here’s the story big Pharma doesn’t want you to know https://t.co/feBPa5w46z

[Wall Street Apes @WallStreetApes]

Test results show Girl Scout Cookies are extremely toxic, ALL OF THEM

Joe Rogan “They're f*cking toxic as f*ck”

- 100% of Girl Scout cookies contained glyphosate, controversial herbicide in Roundup
- 88% contain toxic metals like arsenic, lead, and mercury
- Key finding Thin Mints had the highest glyphosate levels, levels at 111.07 PPB. This is 334 TIMES what experts say is harmful
- Peanut Butter Patties had the highest heavy metal contamination with lead reaching 42.5 PPB and aluminum at 27,500 PPB
- 76% of cookies tested exceeded cadmium safety limits
- 96% contained lead

[John @V333DX]

https://t.co/Y7yhgia8Jw

[John @V333DX]

@twatterbaas

[Vani Hari @thefoodbabe]

Tomorrow at NOON I'm finalizing the petition signatures to deliver to Kellogg’s headquarters. At the last count, over 245,000+ Americans have added their voice, asking Kellogg’s to sell us the same safer cereals they sell in other countries. If you haven’t signed yet, this is your last chance to add your name: https://t.co/fMHRu3jReY

@calleymeans, @humankarp, @yoalexrapz, @realfoodology, @drjoelgator, @drjoshaxe, @livingmaxwell, @drwillcole, @TheEarthDieter, @bewellbykelly, @maxlugavere, @CaseyMeansMD, @travelingenes, @MikhailaFuller, @JillianMichaels, @ferrisbuhler81

[Pierre Kory, MD MPA @PierreKory]

If DMSO was used for strokes and spinal cord injuries, millions would be spared from death, paralysis, and disability. As an ICU doc, I am in disbelief the FDA has kept this from us for decades. The evidence @MidwesternDoc presents here is mind-blowing.
https://t.co/UKgLPiFeKl

[Vani Hari @thefoodbabe]

Watch this ‘til the end! Please take a quick moment to share this video and sign our petition at https://t.co/fMHRu3jReY

We are delivering our petition signatures to @KelloggsUS Headquarters on October 15, 2024.

Details to come on the big event. Make sure you sign the petition so you are the first to know. You are making a real difference.

Thank you for standing up for the health of our children and every citizen in the country. We can’t allow American food companies to do this any longer!

@calleymeans @humankarp @SenRonJohnson @KelloggsUS @RobertKennedyJr @jordanbpeterson @ChrisPalmerMD @MartyMakary @maxlugavere @CaseyMeansMD @travelingenes @realfoodology @yoalexrapz @MikhailaFuller @JillianMichaels