Weichao Li

PostDoc at Scripps Research in @HuangMia @_chrisgparker_ lab. Chemical Biology. Focus on chemical proteomics.

[Chris Parker @_chrisgparker_]

Check out our recent collaboration with @abbvie in @CellChemBiol. We identifed compounds that potently clear tau aggregates. After chemoproteomics and functional studies, we found it covalently targets ER protein P4HB (after metabolic activation). https://t.co/NAo6uHXSAV

[Mia Huang 黃雪兒 @HuangMia]

Thrilled to collaborate with these groups and show how N-linked glycosylation influences the binding of small molecules to the proteome! #glycotime

[Chris Parker @_chrisgparker_]

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with @ForliLab, @HuangMia & @bmsnews. https://t.co/YOADhyAZPb

[Prof. Nikolai Slavov @slavov_n]

Proteins are dynamic.
These dynamics animate life.

[Chris Parker @_chrisgparker_]

Excited to share the final version in
@nchembio. Lots more mechanistic insights & characterization, including our inhibitors disrupt PPIs with mTOR components & induce lysosomal degradation of SLC15A4, & more. A promising target for autoimmune conditions. https://t.co/9qZLh7hRo8

[Scripps Research @scrippsresearch]

A new @nchembio study, led by @_chrisgparker_ alongside Jacob M. Wozniak and Weichao Li, created a high-resolution technique for finding new druggable sites for any human disease, from cancer to Alzheimer’s disease.

More at: https://t.co/tezjxQsHO3

[Chris Parker @_chrisgparker_]

https://t.co/8CjwrKRNkQ Delighted to share our recent work. We developed an enhanced chemoproteomic workflow to determine PAL probe interaction sites in cells, enabling ID of diverse binding pockets, providing evidence of their chemical tractability & more w/@ForliLab & @bmsnews

[Chris Parker @_chrisgparker_]

Excited for this @scripps Chem collaborative work out in @Nature w/@BaranLabReads & Lairson Lab. Has a bit of something for everyone…herculean total synthesis, structural reassignment, chemoproteomics, new druggable target, in-depth functional characterization & more

[Baran Lab @BaranLabReads]

The final version of this study was published today in @Nature : https://t.co/KySrZh6PcS

[Mia Huang 黃雪兒 @HuangMia]

Humbled to be among this amazing cadre of scientists! Grateful for awesome team members @scrippsresearch that are eager to make an impact on #glycotime! Thank you also to a village of mentors and letter writers. #SloanFellow

[Chris Parker @_chrisgparker_]

Big congrats to Junchen and @BaranLabReads on this feat! Excited to be able to contribute w/@WChembio to this story. A great example of how enabling total synthesis can be to reveal new and exciting biology.

[Chris Parker @_chrisgparker_]

Happy to share our (w/ @Teijaro_Lab) integrated chemoprotoemic approach to develop functional inhibitors of SLC15A4 - a challenging target that controls some exciting biology

[Chris Parker @_chrisgparker_]

The final version of this work is now out in @J_A_C_S. A big congrats to Wesley, Anny and team!
https://t.co/5Bfj0GmGKv

[Weichao Li @WChembio]

@AdibekianG @VCVCCA Oh, that's my paper 😁

[Weichao Li @WChembio]

Check out our newest work on using chemoproteomic platform to exploring unexpected folate-interacting/binding proteins and reveals folate-modulated growth and development in Arabidopsis. Collaborate with fantastic people from CAAS and UGhent @ResearchUGent. @ThePlantCell

[The Plant Cell @ThePlantCell]

The 5-formyl-tetrahydrofolate proteome links folates with C/N metabolism and reveals feedback regulation of folate biosynthesis #PlantSci https://t.co/duXu1uAODo

[Amit Jaisi @jaisi_lab]

Online @ACSCatalysis Reports first #ascorbylatedalkaloids #enzyme in #securinegaalkaloids biosynthesis. We reveal the key intermediate in the biosynthesis of C-2 and C-3 functionalized derivatives of #Securinega alkaloids
#firstcorrespondingauthorpaper https://t.co/h2GTY5dZmQ

[Zak Vilen @ZakVilen]

Thrilled to share my first publication as a first author! It's out! It's exciting! Glycans! 🔺🟦🟢🟡
@ScrippsGradPrgm @scrippsresearch #glycotime
https://t.co/qgZzh1HlXA

[nɹnznʎ @yuzururururu]

How postdoc set up a reaction

[Mia Huang 黃雪兒 @HuangMia]

Woohoo! We are ecstatic to share our latest work "Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling." Grateful to reviewers who provided feedback, even in a pandemic. #glycotime @geno_joeh @WChembio @_chrisgparker_ https://t.co/94pDubw7M4