Wayland Cheng Lab

Biophysical and structural studies of ligand-gated ion channels. Lipid modulation. @WUSTL_AnesRsrch Washington University Department of Anesthesiology

[Wayland Cheng Lab @WChengLab]

Our study on nanodiscs and ion channel structure is now published: https://t.co/PZ6gvXLIx4. We hope this will spur more consideration into the impact of nanodiscs on membrane protein structure.

@VikramDalal_37 @PageAnesthesia @GraceBrannigan @WUSTL_AnesRsrch

[Misha Kudryashev 🔬 ❄🕊️ @MishaKudryashev]

This is a very interesting paper showing that nanodiscs, typically used to preserve lipids for structural analysis of membrane proteins, can affect the structure of the target protein.
First paper I read this year, happy 2024!
https://t.co/cH8ggsfRJY

[bioRxiv Biophysics @biorxiv_biophys]

Structural mechanism of lipid modulation of pentameric ligand-gated ion channel activity https://t.co/iIXygUqNqB #biorxiv_biophys

[Philipp Schmidpeter @iHeart_proteins]

Another paper from my postdoc with @CrinaNimigean on lipid modulation of an ion channel is out now. Great effort by @thon_oli further showcasing the value of a great model system. Congrats to the entire team!
https://t.co/AcJye0p2dw

[Wayland Cheng Lab @WChengLab]

@firewhenreddy @USFHealthMed Congrats Krishna!

[Misha Kudryashev 🔬 ❄🕊️ @MishaKudryashev]

I liked the reaction on the soundtrack/musical synopsis for our last paper, maybe every paper should have one. If you haven't seen/heard it yet, weekend is coming !
Paper @embojournal https://t.co/wCzUlhcMKg
Soundtrack by me and byteBBY @BebeByte
https://t.co/1tYtHPBmzS

[Chakrapani_Lab @Chakrapani_lab]

Join our team at Case Western Reserve University!
#CWRUSOM #cryoEM #Ionchannels
https://t.co/ZkVQL2VAiZ

[Baron Chanda @ChandaLab06]

Structures of channels in Open conformation are rare. Thrilled to share our latest manuscript..
Structural basis for hyperpolarization-dependent opening of human HCN1 channel https://t.co/L10NUeZWyk

[Wayland Cheng Lab @WChengLab]

@DastvanLab @NCI @NCICancerBio @amin_nci Congratulations Reza!

[Wayland Cheng Lab @WChengLab]

@WUSTL_AnesRsrch @ChandaLab06 Congrats Jenna!

[Filip Van Petegem @FilipPetegem]

A postdoc position is available in our lab to study how ion channels communicate with one another. Cryo-EM, electrophysiology, protein biophysics. A great opportunity for structural biologists to learn electrophysiology methods or vice versa.
https://t.co/FWLrNqu2UK

[Wayland Cheng Lab @WChengLab]

@mackthompson88 Interesting title! Looking forward to reading this. Congrats Mackenzie!

[Wayland Cheng Lab @WChengLab]

@TaoChelab @sushmajumdarlab @ASPET @WUSTL_AnesRsrch @ClinicPharmSTL Congratulations Tao!

[Brannigan Lab @BranniganLab]

Celebrating another year of successful collaboration with the @WChengLab at the Dandelion. Looking forward to seeing you in LA for #BPS2025!

[Grace Brannigan @GraceBrannigan]

These simulations of membrane proteins in nanodiscs were so fun. Thank you @WChengLab for your continued enthusiasm for simulations that go beyond the basics - we are lucky computational collaborators! @VikramDalal_37 @PageAnesthesia

[Wayland Cheng Lab @WChengLab]

@Chakrapani_lab @LuisOctavioR @KevinCFelt @martafilizola Congrats everyone! Look forward to reading this!

[Wayland Cheng Lab @WChengLab]

@danielmihaylov7 @MishaKudryashev Also, there is still some variability in M4 resolution of ELIC structures from other studies using MSP1E3D1 and SMA. See agonist-bound ELIC in MSP1E3D1 (emd-20968).

[Wayland Cheng Lab @WChengLab]

@danielmihaylov7 @MishaKudryashev The impact of M4 interactions with the nanodisc is something we are continuing to work on, so hopefully will have more insights soon.

[Wayland Cheng Lab @WChengLab]

@danielmihaylov7 @MishaKudryashev Yes, M4 is generally not as well resolved but there is density in the unsharpened maps to observe major differences in helix orientation. From the MD simulations, one can also see how the nanodisc can impact the orientation of M4.

[Wayland Cheng Lab @WChengLab]

@danielmihaylov7 @MishaKudryashev Agree with @MishaKudryashev. We focused on the backbone structure of the helices (instead of rotamers) and observed 1-2 angstrom differences, which we believe are significant.

[Vikram Dalal @VikramDalal_37]

It's my pleasure to share that I have been awarded an AHA postdoctoral fellowship. I would like to acknowledge my mentor @WChengLab for unimaginable support, referres: @Pravindrak_IITR, @ShaillyTomar and Alex Evers, and @American_Heart for belief in my proposal.
@WChengLab

[Wayland Cheng Lab @WChengLab]

@ScheuringLab @HughHemmings @WCMAnesthesia @WCMResearch Congrats, Simon!