WVU Pathology for Medical Students

Official Twitter account of @WVUMedSchool path curriculum, by @MBDFlanaganMD & @WVUPathology faculty, to engage WVU & all preclinical med students. #FOAMed

[WVU Pathology for Medical Students @WVUPath4MS]

Welcome to the Twitter account for the WVU School of Medicine MS2 Pathology801 course! Please read our guidelines for participation: https://t.co/wODcZKnUzE

[WVU Pathology for Medical Students @WVUPath4MS]

The best answer option here is Diabetes Mellitus. Cigarette smoking certainly increases the risk of death for every PPD. For brief historical perspective on DM "equivalency" to CHD see https://t.co/mi9iNWKsGk

[WVU Pathology for Medical Students @WVUPath4MS]

Pathology questions return! Which of the following modifiable risk factors for atherosclerosis doubles the risk of myocardial infarction and is considered a coronary heart disease risk "equivalent"?

[WVU Pathology for Medical Students @WVUPath4MS]

Good luck on your exams tomorrow! @MBDFlanaganMD @JeffreyVosMD

[WVU Pathology for Medical Students @WVUPath4MS]

If we are looking at a young patient with an infection (cold AIHA/agglutinin disease), often antibody titres are rather high — then, acutely, you can see more intravascular hemolysis (schistocytes).

[WVU Pathology for Medical Students @WVUPath4MS]

Which of the following cells is most characteristically seen in autoimmune hemolytic anemia? @MBDFlanaganMD @JeffreyVosMD @WVUHemePath

[WVU Pathology for Medical Students @WVUPath4MS]

Cold/IgM-mediated will be positive for C3. Even still, it’s more common to see this chronically in older adults; since it’s chronic, again, mostly extravascular.

[WVU Pathology for Medical Students @WVUPath4MS]

Typical HUS it is as it most likely is caused by E. coli O157:H7. For aHUS, think autoantibodies to complement proteins.

[WVU Pathology for Medical Students @WVUPath4MS]

I am young kid plagued by a bacterial illness that is giving me diarrhea and causing my RBCs to lyse intravascularly. I’m looking a little yellow, and my urine appears dark. My platelet count is 25 k/uL, and my creatinine level is 5.94 mg/dL. What condition do I likely have?

[WVU Pathology for Medical Students @WVUPath4MS]

Anemia of chronic disease also would be more of a production issue. The issue here is iron sequestration, where iron is around but not readily available because it's retained by reticuloendothelial cells. Unavailable iron? Decreased hemoglobin synthesis.

[WVU Pathology for Medical Students @WVUPath4MS]

Which of the following contributes to peripheral loss or destruction of red blood cells (as opposed to diminished erythropoiesis)? Choose the *best* answer option. @JeffreyVosMD @MBDFlanaganMD

[WVU Pathology for Medical Students @WVUPath4MS]

Strong work, everyone! Yes, hereditary spherocytosis is the best answer option here. For renal failure, there'd be decrease epoetin, which would reduce the production of RBCs.

[WVU Pathology for Medical Students @WVUPath4MS]

Burkitt is the answer here😃. The other options are small, not intermediate in size. While Mantle Cell in particular can be aggressive, it does not respond well to chemotherapy. Note: Follicular Lymphoma can transform to a diffuse LARGE B-cell lymphoma.

[WVU Pathology for Medical Students @WVUPath4MS]

Which of the following is characterized as an intermediate-sized and aggressive B-cell lymphoma that is fortunately very responsive to intensive chemotherapy? HINT: this entity has a relationship with Epstein-Barr Virus. @JeffreyVosMD @MBDFlanaganMD @AShmooklerMD

[WVU Pathology for Medical Students @WVUPath4MS]

Correct answer: AB. AB blood (uncommon) means RBCs express A and B antigens, which means that in plasma there are neither anti-A nor anti-B antibodies that could potentially cause hemolysis of recipient A and/or B RBCs.

[WVU Pathology for Medical Students @WVUPath4MS]

Hi! I'm a blood donor. You really would appreciate my blood -- especially my plasma, which is universally accepted by all because I do not offer antibodies to A and B antigens present on red blood cells. Unfortunately, though, I'm not commonly found. What's my blood type?

[WVU Pathology for Medical Students @WVUPath4MS]

Note how two of the answer options connect to a particular cell line: CD38 & CD138 (plasma cells).🧐 In a board exam situation, you can likely rule-out both answer options and increase your chances of getting to the right answer.😉

[WVU Pathology for Medical Students @WVUPath4MS]

Which of the following cluster of differentiation markers is characteristically absent in plasma cells?

[WVU Pathology for Medical Students @WVUPath4MS]

CD20 is characteristically absent from plasma cells. Other markers including CD19 and the markers more specific to plasma cells -- CD38 and CD138 -- are present on plasma cells.

[WVU Pathology for Medical Students @WVUPath4MS]

[3/n] Thromboxane A2 does contribute to platelet activation. However, most commonly you'll encounter acquired defects associated with exogenous aspirin administration.

[WVU Pathology for Medical Students @WVUPath4MS]

You are a molecule essential for thrombosis. Your function is to participate in a series of activation steps. Your absence is caused by a common X-linked disorder. Which of the following best fits your description? @WVUMedSchool @AShmooklerMD @MBDFlanaganMD @JeffreyVosMD

[WVU Pathology for Medical Students @WVUPath4MS]

[2/n] von Willebrand Factor is a good thought, but this participates in the adhesion step of primary hemostasis. Furthermore, von Willebrand Factor disorders (von Willebrand Disease) exhibit an autosomal inheritance pattern most commonly dominant and less so recessive.