Wang Lab

Research focused on the role of basal ganglia circuitry in neuropsychiatric diseases, including substance use disorders and Alzheimer's disease

[Wang Lab @WangLabTAMHSC]

https://t.co/PT3yam4aHk

[Wang Lab @WangLabTAMHSC]

Excited to announce our new publication in Neuropharmacology, showing that chronic alcohol exposure produces pathology-dependent corticostriatal circuit remodeling in mouse models of Alzheimer's disease! This paper is available now and linked below.

[Neuron @NeuroCellPress]

Online now: Dual-engram architecture within a single striatal cell type distinctly controls alcohol relapse and extinction https://t.co/uwjoFuipbL

[Wang Lab @WangLabTAMHSC]

Thrilled to announce our new publication in Neuron, showing that distinct striatal dMSN ensembles encode alcohol relapse and extinction! These findings, determined using activity-dependent manipulations, suggest potential future ensemble-specific targets for reducing relapse.

[Wang Lab @WangLabTAMHSC]

Excited to share our new paper in Neuropharmacology- Abstinence and extinction differentially tune dorsomedial striatal dMSNs and dopamine during alcohol relapse. Bidirectional control of mPFC→dMSN synaptic plasticity determines relapse vulnerability.

[Wang Lab @WangLabTAMHSC]

Pleased to share our new paper in eLife, "Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons." This paper shows that CRF enhances striatal CIN activity via CRFR1, and that this effect is disrupted by alcohol.

[Wang Lab @WangLabTAMHSC]

Excited to share our new paper in Neuropharmacology: "Perinatal and Prenatal Alcohol Exposure Impairs Striatal Cholinergic Function and Cognitive Flexibility in Adult Offspring." It shows PAE impairs striatal cholinergic activity and promotes compulsive alcohol drinking.

[Wang Lab @WangLabTAMHSC]

Pleased to announce that one of our students, Yufei (@bxgttneuron), was awarded the 2024 John P. McGovern Fellowship Award by the Texas Research Society on Alcoholism! Congratulations Yufei!

[Wang Lab @WangLabTAMHSC]

https://t.co/irpwlZBtAL

[Wang Lab @WangLabTAMHSC]

Pleased to announce our recent publication in ACER, "Optogenetic inhibition of light-captured alcohol-taking striatal engrams facilitates extinction and suppresses reinstatement"! Alcohol-taking neurons (trapped via FLiCRE) impact both alcohol-seeking and taking.

[Wang Lab @WangLabTAMHSC]

Lab lunch celebrating our summer SURGe student, Julia's, last week! It's been a pleasure to work with you!
"The Wang lab has been so welcoming and taught me so much. I'm so excited to use all that I've learned in the future and I'm so grateful for this experience!"

[Wang Lab @WangLabTAMHSC]

Friday marked an end of an era as Dr. Himanshu Gangal (@himanshu1991) concluded his journey with us. As a PhD student, he made significant contributions (https://t.co/DILRyZfgSY). He's set to begin a new chapter as a postdoc at @broadinstitute. We wish him the best of luck!

[Wang Lab @WangLabTAMHSC]

Thrilled to announce that a member of our lab, @xueyi_xie, was recently awarded the RSA (Research Society on Alcohol) Doctoral Student Small Grant, a prestigious award which was only awarded to four select recipients this year. Our lab is very proud of and excited for him!

[Wang Lab @WangLabTAMHSC]

@douglasftome @ClopathLab @xueyi_xie Link to the paper available here!

https://t.co/gQUe2rGzSb

[Wang Lab @WangLabTAMHSC]

Interesting paper published in Nature Neuroscience by @douglasftome in @ClopathLab was presented at our weekly journal club by @xueyi_xie! Great look into the temporal evolution of engrams, and interesting use of Cal-Light for neuronal labeling!

[Wang Lab @WangLabTAMHSC]

A fascinating article published in @NatureNeuro presented by @chen_rui_feng at our weekly journal club last night. Interesting look at the role of microglia under and post anesthesia, and some beautiful confocal images!

[Nature Neuroscience @NatureNeuro]

#Microglia transiently boost post-#anesthesia neuronal activity by physically shielding inhibitory inputs

@LongJun_Wu @KoichiHaruwaka @MayoClinicNeuro @MayoClinic

https://t.co/MBeu42sI5f

[Nature Neuroscience @NatureNeuro]

#Microglia transiently boost post-#anesthesia neuronal activity by physically shielding inhibitory inputs

@LongJun_Wu @KoichiHaruwaka @MayoClinicNeuro @MayoClinic

https://t.co/MBeu42sI5f