Gastroenterologist, Translational research, microbiome & integrative omics analyses, host-microbe interactions in the context of IBD and other chronic diseases
Our Consensus statement on #microbiome testing in clinical practice is out in @LancetGastroHep! https://t.co/atqPLiYJE7 Here we recommend how to standardise the framework for test release (indications, pre-testing protocols, sequencing & analysis, result reporting). A thread🧵⬇️
Congratulations to Laura Bolte @umcg. Cum Laude distinction for her PhD studying the relation between #diet#microbiome and #immunity in #ibd and response to immune checkpoint inhibition. Work in her PhD thesis has been published in @NatureMedicine@Gut_BMJ and @JAMAOnc
📢 New Study Alert! 📢Happy to share the latest results from the Lifelines NEXT Mother-Infant cohort! (1/8). Here we profile the gut microbiome in 4,577 longitudinal samples from 714 mother-infant pairs, from 12 weeks of pregnancy to 1 year post-birth https://t.co/KUiz6Usz9D
I am incredibly proud that 2 out of the 5 top abstracts #UEGWeek are from our department @umcg (out of >3500 abstracts). Huge congratulations to @BourgonjeArno and Anne van der Waai for their groundbreaking work and this important recognition!
@my_UEG@LifelinesNL@researchumcg
Amazing meeting at the Paris Immuno-Oncology Conference 2024! So much food for thought from top leaders in microbiome and immunology: @EranElinav, @derosa__lisa, @nsegata, @WeersmaLab, and more. Honored to present our latest work published in @NatImmunol with @julienCMarie1.
I am incredibly proud that 2 out of the 5 top abstracts #UEGWeek are from our department @umcg (out of >3500 abstracts). Huge congratulations to @BourgonjeArno and Anne van der Waai for their groundbreaking work and this important recognition!
@my_UEG@LifelinesNL@researchumcg
Join us on October 13 for the presentation of our Top Abstract Prize Awardee, Arno R. Bourgonje:
CROHN'S DISEASE AND ULCERATIVE COLITIS EXHIBIT PRE-DIAGNOSTIC ANTIBODY SIGNATURES WITH SHARED AND DIVERGENT CHANGES TOWARDS DISEASE ONSET 🔬
👉 https://t.co/w0CfE85fdz
#UEGWeek
The gut microbiome acetyltransferase genes were involved in the metabolism of 5-ASA in IBD.
However, new findings from @WeersmaLab et al. didn't replicate the original findings:
https://t.co/aO9q6Qwvgd
#GUTImage from the paper by @CasSwarte et al on
"Multiple indicators of gut dysbiosis predict all-cause and cause-specific mortality in solid organ transplant recipients" via
https://t.co/TzKZ1G0V9Y
@jingyuan_fu @HarmsenHermie @WeersmaLab
In contrast to previous reports we found limited predictive value of the gut #microbiome (and #metabolome) for response to biological therapy in #IBD Still small sample sizes but relatively similar to other studies. @GroMicrobiome@umcgmdl@researchumcg
https://t.co/QReDbXNB8G
Exploring the previously reported gut #microbiome acetyltransferase genes involved in metabolism of 5-ASA in #ibd we could not replicate the original findings from @NatureMedicine in our Dutch 1000IBD cohort. More work needed. @GroMicrobiome
https://t.co/o5ckLJrj9J
#GUTImage from the paper by Gabriels et al entitled
"Fluorescently labelled vedolizumab to visualise drug distribution and mucosal target cells in inflammatory bowel disease" via
https://t.co/HTYRpE11D1
@wouternagengast@researchumcg#IBD#Vedolizumab
(1/6) 📢 New Study Alert! In our randomized controlled trial we compare the gut microbiomes of infants whose mothers received prophylactic antibiotics pre-incision versus post umbilical cord clamping.🤰
https://t.co/9LGkvzLJUW
#GUTPressRelease#GUTInTheNews paper by @CasSwarte et al on
"Multiple indicators of gut dysbiosis predict all-cause and cause-specific mortality in solid organ transplant recipients" via https://t.co/TzKZ1G0V9Y
@jingyuan_fu @HarmsenHermie @WeersmaLab