Wesley Wong Lab

We study the physical basis behind how biological systems work at the nanoscale, focusing on the role of force, using single-molecule and nanoscale methods

[Wesley Wong Lab @WesleyWongLab]

Our light guided molecular patterning method for high-throughput single-molecule studies just published today in Small! Programmable, covalent, multiplexed, accessible.
https://t.co/aWB1hr6ium

[Wesley Wong Lab @WesleyWongLab]

What better way to start the year then with a deep dive into multiplexed force spectroscopy? Check out our review article that just came out in Annual Reviews of Biophysics! https://t.co/S1wZzAtKM2

[Wesley Wong Lab @WesleyWongLab]

Our work on characterizing G-quadruplexes at the single-molecule level is now out in Nucleic Acids Research!
https://t.co/UI06fJUrEa

[Wesley Wong Lab @WesleyWongLab]

Just published in ACS Central Science—our latest work using the Centrifuge Force Microscope to quantify immune-cell interactions. The new setup combines high-throughput force spectroscopy with multichannel fluorescence for single-cell studies. https://t.co/sRLCxSaYui

[Taekjip Ha @taekjip]

high-throughput single-molecule platform to study DNA supercoiling effect on protein–DNA interactions https://t.co/vD3sDJ9mZY

[Wesley Wong Lab @WesleyWongLab]

New preprint on single-molecule mechanostructural fingerprinting! https://t.co/AhoHsJAylg We use DNA nanoswitch calipers to characterize the geometry and mechanical stability of telomeric DNA G-quadruplexes. #Biophysics #SingleMolecule #Mechanobiology #DNAnanotech

[Wesley Wong Lab @WesleyWongLab]

@qt314neko @biorxivpreprint Thanks for your comment! Our current patterning resolution is around a micron--we are using this larger spacing to accommodate for bead size and DNA tether length in our single-molecule force measurements. Can go denser if needed.

[Wesley Wong Lab @WesleyWongLab]

Excited to share our new preprint! It's a light-guided approach for precise and programmable molecular patterning, enabling multiplexed single-molecule force spectroscopy—no lithography needed. Read more at @biorxivpreprint: https://t.co/RQcFVQv4tD #Mechanobiology #SingleMolecule

[Wesley Wong Lab @WesleyWongLab]

@ZhanglabY Thanks Yongli!

[Wesley Wong Lab @WesleyWongLab]

Check out our latest manuscript on high-throughput force spectroscopy! We've developed a next-generation CFM with multichannel fluorescence capabilities to study the the avidity of immune-cells at the single cell level
https://t.co/H7f7QuScZi

[bioRxiv Biophysics @biorxiv_biophys]

High-Throughput Centrifuge Force Microscopy Reveals Dynamic Immune-Cell Avidity at the Single-Cell Level https://t.co/9FQYfpwJJ3 #biorxiv_biophys

[Wyss Institute @wyssinstitute]

To celebrate #DNADay, William Shih, @WesleyWongLab, & Peng Yin discuss how they're using DNA, what problems they can solve with DNA nanotechnology, and their progress towards the ambitious founding vision of our Molecular Robotics Initiative.
https://t.co/fe5PXZiImE

[Wesley Wong Lab @WesleyWongLab]

Check out our latest work on measuring cell-adhesion with the CFM on Sunday (Exhibit Hall AB at 1:45, 801-Pos/B567), and on structural single-molecule proteomics with nanoswitch calipers on Monday (204AB at 12:35, 958-FlashTalk; Exhibit Hall AB at 1:45, 1601-Pos/B554)

[Wesley Wong Lab @WesleyWongLab]

Just landed in Philly for @BiophysicalSoc Looking forward to Single-molecule and nanoscale subgroups tomorrow! #bps2024.

[Wesley Wong Lab @WesleyWongLab]

@nr_forde Ken, looking forward to seeing you at #BPS2024! Let's keep spreading the word about the CFM! :) And Nancy, have a good time APS!

[Wesley Wong Lab @WesleyWongLab]

@cees_dekker Nice shot! Didn't notice you taking the pic or I would have smiled :)

[Wesley Wong Lab @WesleyWongLab]

Beautiful view! Having a wonderful time at #SMBLesHouches. Thank you @RuedaLab
and @NynkeDekkerLab for organizing this amazing conference.

[Kasia Tych @BiophysK]

What a view to wake up to! Looking forward to meeting everyone and hearing about all of the exciting single-molecule science at the #SMBLesHouches meeting.

[Wesley Wong Lab @WesleyWongLab]

It was such an enjoyable and lively dinner! Thank you @cees_dekker for flying here to speak!

[Cees Dekker @cees_dekker]

One great aspect of science is its very international character where you get to meet colleagues/friends from all over the world - in this picture @WesleyWongLab @JoeLoparo @shihlab @taekjip & Sua Myoung at dinner after my seminar at Harvard.

[Wesley Wong Lab @WesleyWongLab]

Delighted to host @cees_dekker today for the BCMP Seminar! Packed house and lively discussions!

[Harvard Med BCMP @HMS_BCMP]

Please join us in-person for the BCMP seminar on Thursday, January 11 at 12:30pm by Cees Dekker, KNAW Royal Academy Professor, Dept of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology. @tudelft

[Wesley Wong Lab @WesleyWongLab]

@HalvorsenLab @J_A_C_S Thanks Ken! I made the image using DALL-E

[Wesley Wong Lab @WesleyWongLab]

Single-molecule 3D reconstruction for structural proteomics--check out our latest work just published in JACS @J_A_C_S! https://t.co/rE73CzoS2z