We study the physical basis behind how biological systems work at the nanoscale, focusing on the role of force, using single-molecule and nanoscale methods
Our light guided molecular patterning method for high-throughput single-molecule studies just published today in Small! Programmable, covalent, multiplexed, accessible.
https://t.co/aWB1hr6ium
What better way to start the year then with a deep dive into multiplexed force spectroscopy? Check out our review article that just came out in Annual Reviews of Biophysics! https://t.co/S1wZzAtKM2
Just published in ACS Central Science—our latest work using the Centrifuge Force Microscope to quantify immune-cell interactions. The new setup combines high-throughput force spectroscopy with multichannel fluorescence for single-cell studies. https://t.co/sRLCxSaYui
New preprint on single-molecule mechanostructural fingerprinting! https://t.co/AhoHsJAylg We use DNA nanoswitch calipers to characterize the geometry and mechanical stability of telomeric DNA G-quadruplexes. #Biophysics#SingleMolecule#Mechanobiology#DNAnanotech
@qt314neko@biorxivpreprint Thanks for your comment! Our current patterning resolution is around a micron--we are using this larger spacing to accommodate for bead size and DNA tether length in our single-molecule force measurements. Can go denser if needed.
Excited to share our new preprint! It's a light-guided approach for precise and programmable molecular patterning, enabling multiplexed single-molecule force spectroscopy—no lithography needed. Read more at @biorxivpreprint: https://t.co/RQcFVQv4tD #Mechanobiology#SingleMolecule
Check out our latest manuscript on high-throughput force spectroscopy! We've developed a next-generation CFM with multichannel fluorescence capabilities to study the the avidity of immune-cells at the single cell level
https://t.co/H7f7QuScZi
To celebrate #DNADay, William Shih, @WesleyWongLab, & Peng Yin discuss how they're using DNA, what problems they can solve with DNA nanotechnology, and their progress towards the ambitious founding vision of our Molecular Robotics Initiative.
https://t.co/fe5PXZiImE
Check out our latest work on measuring cell-adhesion with the CFM on Sunday (Exhibit Hall AB at 1:45, 801-Pos/B567), and on structural single-molecule proteomics with nanoswitch calipers on Monday (204AB at 12:35, 958-FlashTalk; Exhibit Hall AB at 1:45, 1601-Pos/B554)
What a view to wake up to! Looking forward to meeting everyone and hearing about all of the exciting single-molecule science at the #SMBLesHouches meeting.
One great aspect of science is its very international character where you get to meet colleagues/friends from all over the world - in this picture @WesleyWongLab@JoeLoparo@shihlab@taekjip & Sua Myoung at dinner after my seminar at Harvard.
Please join us in-person for the BCMP seminar on Thursday, January 11 at 12:30pm by Cees Dekker, KNAW Royal Academy Professor, Dept of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology. @tudelft