In 2015, a woman accidentally snorted 55 mg of pure LSD, because she thought it was cocaine, which is 550 times the recommended recreational dose of 100 micrograms. She not only survived, but she eventually found that the foot pain she had suffered from since her 20s was dramatically reduced.
This case was later written up in medical literature because the dose was so extreme it should have been lethal. At the time she took it, LSD was already known to be active in the microgram range, not milligrams. Fifty-five milligrams is not just an overdose, it is thousands of doses condensed into a single event. Reports say she vomited for hours, lost motor control, and drifted in and out of consciousness, but her vital signs stabilized without organ damage. Later neurological follow-ups suggested a change in how her brain processed chronic neuropathic pain. Researchers noted that LSD binds to serotonin receptors at very high affinity, which can alter pain signaling pathways. One single anecdote does not equal a clinical treatment, but the case became part of a broader renewed discussion about psychedelics being investigated, in controlled medical settings, for depression, PTSD, terminal anxiety, and pain disorders.
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