🧵 Antibodies in SLE: Beyond ANA:
Tweet 1:
ANA is the entry point into lupus.
But lupus is not defined by ANA alone.
👉 Specific autoantibodies confirm diagnosis, predict organ involvement, track activity & guide prognosis.
Let’s decode them ⬇️
@IhabFathiSulima @DrAkhilX @CelestinoGutirr@Janetbirdope@ACRheum #MedTwitter #RheumTwitter
#ACR25 Abstract 1526
“Guidance for #Steroid Tapering in Systemic Lupus Erythematosus”
101 international experts reached Delphi consensus on CS tapering strategies in #SLE.
🔹 Practical guidance for real-world tapering across disease activity levels and organ involvement.
Now published: The 2025 ACR Guideline for the Treatment of Systemic Lupus Erythematosus
📄 Read the paper: https://t.co/56eOK86lmn
ℹ️ See additional content and resources on this guideline at https://t.co/PVEyOkY14w
@Janetbirdope’s #ACR25 pearls remind us:
Order ANA only when clinical suspicion exists
Never repeat a positive ANA
ENA only if ANA+
❌ Ignore dsDNA if ANA– (except anti-Ro52)
Stop serial dsDNA/C3/C4 if stable
Smart lab use saves patients anxiety and systems money.
#SLE
Second edition of Rheumatology Made Ridiculously Simple is out now! This edition we actually have a professional artist and are no longer relying on my own bad drawings! #meded#rheumatology
Heritability of asymptomatic ANA positivity is 25%. Asymptomatic ANA positive individuals did not exhibit increased cumulative genetic risk for lupus compared to ANA negative individuals. Genetic study of 1,955 asymptomatic ANA+ v 3,634 asymptomatic ANAnegs. https://t.co/cdYjDQCFQF
JAMA Patient Education Page - Plantar Fasciitis
Plantar Fasciitis accounts for more than 1 million US clinic visits per year. People at risk include obesity, jobs w/ prolonged standing https://t.co/uijbcbQ0sz
✅ VERY VISUAL consensus schematic for #LUPUS#NEPHRITIS diagnosis and treatment by the Brazilian Society of Rheumatology @rheuma_brazil 👍 Congrats to all authors, including dos Reis Neto & Monticielo👏
Full Download link: https://t.co/lgXlj0U0Xo