RNAWorld

[RNAWorld @WorldRNA]

@gonenlab Ok. I haven’t kept up with the development lately. What is the largest protein ever diffracted and the structure was determined by microED? Flat mostly?

[RNAWorld @WorldRNA]

@gonenlab Bcz microED diffraction is limited by thickness of 2D crystals and there is up limit on the number of layers along Z, right?

[RNAWorld @WorldRNA]

@DouglasYaoDY Respectfully, I can’t disagreed more…based what we do…

[RNAWorld @WorldRNA]

@Nature Think everyone looks and behaves differently. Well, each RNA molecule has different conformation in a physiologically relevant Mg2+ concentration. How to determine the 3D structures of individual RNA molecules has not been possible till now.

[nature @Nature]

Nature research paper: Determining structures of RNA conformers using AFM and deep neural networks

https://t.co/7h0xXrNxcA

[RNAWorld @WorldRNA]

@Nature Visualizing structure and conformational heterogeneity of RNA molecules in physiologically relevant Mg+2 concentration

[nature @Nature]

Nature research paper: The conformational space of RNase P RNA in solution

https://t.co/IfKTdf8Jcd