XenoTech

A leading #drugdevelopment #CRO for #invitro/#invivo #contractresearch studies including #ADME / #DMPK / Drug-#DrugInteractions & products for #drugmetabolism,…

[XenoTech @XenoTechllc]

Looking for new #drugmetabolism and #druginteraction scientific content and news from XenoTech? Then head over to @BioIVT for valuable updates on #ADME research as well as normal and disease-state #biospecimens and related test systems for a variety of additional applications!

[American Association of Pharmaceutical Scientists @AAPSComms]

Explore two #transporter case studies highlighting solutions to inconclusive results. AAPS is proud to host the #eChalkTalk, Uncooperative Drugs in In Vitro Transporter Research, on Wednesday, March 27, with @BioIVT. This eChalk Talk is free for all: https://t.co/pjgHEU8iTK

[XenoTech @XenoTechllc]

Drug-induced liver injury (DILI) is the leading cause of acute liver failure. This #scientificposter from @BioIVT looks at the effect of drugs that cause cholestatic DILI on bile acid transport and metabolism: https://t.co/cHwqstrB8c

[XenoTech @XenoTechllc]

Hot off the press!

[BioIVT @BioIVT]

New @pharma_eu Focus Europe article: “Blood to Plasma Ratio: An Important Determinant of the #Pharmacokinetic Behavior of Drugs.” Read how measuring drug concentration in both compartments is required for accurate pharmacokinetic assessment: https://t.co/Dp9hhLqcJH

[XenoTech @XenoTechllc]

Have questions about our new tiered #invitro #ADME study options? Join Dr. Barbara, @BioIVT’s KC Site Lead, for a quick presentation and Q&A on July 27th to learn more about the benefits of each tier and how to decide which is right for you: https://t.co/bCW3HEYhPM

[XenoTech @XenoTechllc]

"When should I be planning my #ADME / #DMPK / drug-#druginteraction studies?" We've got some answers-- read our blog post discussing strategic timing of #invitro #preclinical studies to set your drug compound up for success: https://t.co/rhYAJLbvon

[XenoTech @XenoTechllc]

Loss of processes inside #hepatocytes, like #drugmetabolism, induction, inhibition (metabolic and #drugtransporters), #druginteractions and #hepatotoxicity results in subpar #invivo predictions. Learn about model selection in this @BioIVT #scientificposter https://t.co/eTSaTFyWDR

[XenoTech @XenoTechllc]

Make sure to follow @BioIVT to access the poster once it’s available:

[BioIVT @BioIVT]

We’re presenting a #scientificposter on ADCs: In Vitro Evaluation of #Pharmacokinetic #DrugInteraction Potential at next week’s #ADME GRC (https://t.co/ccc7CaytCj). Request a meeting with Dr. Limaye if you’ll be attending or would like to discuss: https://t.co/anfGFTQJqv

[XenoTech @XenoTechllc]

Next week we’ll send our first news and resources update through BioIVT’s email system and switch to posting through BioIVT’s social media. Make sure you’ve resubscribed (https://t.co/bbHIHBecNk) and follow @BioIVT so you don’t miss out.

[XenoTech @XenoTechllc]

After Dr. Limaye presented #ADME and drug- #druginteraction studies geared towards a #toxicology audience, we posted the important highlights from the presentation in our blog here: https://t.co/9PlOuxTAJf and the slides can be downloaded here: https://t.co/rXHuqb9ho1

[XenoTech @XenoTechllc]

Do you know which #invitro #drugmetabolism and drug-#druginteraction studies you actually need to perform? While there may not be an exact checklist, regulatory agencies have made some expectations clear... https://t.co/iwW1RNsaFG

[XenoTech @XenoTechllc]

Interesting symposium with great presentations:

[BioIVT @BioIVT]

Presentations now available! “Improving #InVivo Predictions from #InVitro #Hepatocyte Models: Model Selection, Protein Effects & #DrugTransporter Regulation”; #DrugInteraction Potential of Major Pharmaceutical Excipients on Transporters & Enzymes” and… https://t.co/J2LupCXiB7

[XenoTech @XenoTechllc]

Take a look at our industry survey results to see when most researchers are performing #ADME/#DMPK & #DrugInteractions testing, what the top 4 repercussions & risks are from postponing, & top 3 benefits to running more testing during #preclinical research: https://t.co/Ngoft1Yh0J

[XenoTech @XenoTechllc]

Since many compounds bind to red blood cells, the majority of polled researchers said they regularly conduct red blood cell partitioning with plasma protein binding studies to determine #pharmacokinetic parameters: https://t.co/LoqGty3mVG

[XenoTech @XenoTechllc]

The countdown until the end of use for XenoTech’s current social media accounts has begun. We’ll be making the switch on July 15th, so make sure you’ve followed @BioIVT by then to ensure you don’t miss any important #ADME, #DMPK or #DrugInteraction research news!

[XenoTech @XenoTechllc]

Our next newsletter with links to recordings from our June Symposium, info on our new #invitro #ADME & #druginteractions study tiers, and more is scheduled for early July. Make sure you’ve subscribed to receive emails from @BioIVT in order to receive it! https://t.co/bbHIHBeKCS

[XenoTech @XenoTechllc]

How does #drugmetabolism & #pharmacokinetics fit into #drugdevelopment? Read an overview of #DMPK & derisking strategies associated with using #preclinical #invitro data to evaluate metabolite formation & risk of potential #druginteractions: https://t.co/isnGdJNWey

[XenoTech @XenoTechllc]

Our most popular #ADME blog entry for 2022 was our infographic about how you can leverage your data to showcase your compound in ways that will maximize its value. Take a look! https://t.co/9GXRjVe0uD

[XenoTech @XenoTechllc]

We asked some of our #druginteractions experts to address frequently asked questions about enzyme induction studies and elaborate on recommendations to achieve successful regulatory submission. Take a look at their responses here: https://t.co/GxlFgUGKWv

[XenoTech @XenoTechllc]

We added a @WatersCorp Xevo G3 to our #bioanalytical lineup, the 1st to be installed in the region. It will be used for our #metabolite ID studies, including incubations with @BioIVT #HepatoPac #hepatocyte-fibroblast co-cultures for low turnover compounds: https://t.co/vM3sNs5QaT