Alfred Lee

[Alfred Lee @XtalEngineer]

Very excited to share our work exploiting GS frameworks for structure elucidation of encapsulated guests in @ACSMatLett, @CGD_ACS & @ChemEurJ. The first two in collaboration with @aayusov, Allie Dillon & Mike Ward @nyumdi, & the latter led by @MoTChaudhry
https://t.co/3JOMoPCJV0

[Panče Naumov, PhD ACSF FRSC @Pance_Naumov]

Role of molecular strain in crystallization―Organic crystal structures, which have long been utilized in industrial-scale crystallization, can sometimes undergo sudden and unexpected transitions to alternative, more thermodynamically stable arrangements, resulting in markedly different physical properties. In their article in @J_A_C_S, van de Streek, Neumann et al. present a method for calculating “molecular strain energy” to predict the likelihood that a molecule will adopt its most thermodynamically stable crystal packing arrangement. This study not only elucidates the unexpected crystallization of more stable, novel solid forms but also provides the pharmaceutical industry with a valuable tool for directing resources more effectively. Full article:
https://t.co/F4v383XNy7

[Alfred Lee @XtalEngineer]

Read our latest publication in @CommsChem showcasing ritonavir, the most celebrated case of crystal polymorphism.

[Communications Chemistry @CommsChem]

Predicting the ritonavir crisis by revisiting the polymorph landscape with crystal structure prediction and form 4 structure solution https://t.co/aJZ49BTKfh

[J. Am. Chem. Soc. @J_A_C_S]

A Conceptual Framework for the Crystallizability of Organic Compounds | Journal of the American Chemical Society https://t.co/Ui31wy4AFR

[Michael Hall @DrMichaelJHall]

Less then 10 days to apply for a #Chemistry #PhD with our team at @ChemistryNCL, using high throughput robotics to discover crystallisation conditions for complex #peptides. Learn #crystallography and #SCXRD myself and @Mike_Pro_1978. Sponsored by @Merck
https://t.co/t3IfBGE10n

[Alfred Lee @XtalEngineer]

Just out in the Journal of Pharmaceutical Sciences: A salt or a cocrystal? That is the question. #MerckChemistry

[JPharmSciences @JPharmSciences]

Revisiting the Solid-State Landscape of Creatine Citric Acid: A Salt or a Cocrystal? https://t.co/b8PcW3qGAu

[Ruggiero Group @RugGroup]

Dynamic crystals are so much fun, and there are lots of collaborations involved in this research! More information here -> https://t.co/QXd0UJomgf
Please RT!
@Pance_Naumov @NaumovGroup @leelab_nyu @RuncevskiLab @KM_Hutchins @ItsBenPartridge @brozeklab @BRBchemistry

[Alfred Lee @XtalEngineer]

Our latest work in @ChemEurJ on combining high-throughput experimentation and powder X-ray diffraction to identify promising host-guest complexes for structure elucidation purposes.

[ChemEurJ: Chemistry - A European Journal @ChemEurJ]

Structure Elucidation of Pharmaceutically Relevant Compounds Within Pyrene-Based Frameworks (@MoTChaudhry, Justin Newman, Anisha Patel and Alfred Lee @XtalEngineer) #MerckChemistry https://t.co/inkhJfXTCG

[Alfred Lee @XtalEngineer]

#MerckPharmSci #MerckAnalytical @PurdueIPPH

[JPharmSciences @JPharmSciences]

The importance of surface composition and wettability on the dissolution performance of high drug loading amorphous dispersion formulations https://t.co/kVfSm9tSlZ

[Alfred Lee @XtalEngineer]

@ChEnected Congratulations @DiaoGroup !

[Angewandte Chemie @angew_chem]

Unprecedented Packing Polymorphism of Oxindole: An Exploration Inspired by Crystal Structure Prediction (Alfred Lee, Xiaolong Zhu and co-workers) @XtalEngineer #MerckChemistry https://t.co/KvPExLhPZt

[Alfred Lee @XtalEngineer]

#MerckAnalytical is hiring. Come join us to create new automation capabilities to overcome scientific challenges related to preformulation and formulation development.
https://t.co/jMsfn2i5hz

[Alfred Lee @XtalEngineer]

@HengGroup @yanghuaiyu @BACG_ @JYYHeng @IshaBade @Jianing_Li_ Congratulations on the trifecta!!! 👏🏻

[ACS Materials Letters @ACSMatLett]

Benchmarking Guanidinium Organosulfonate Hydrogen-Bonded Frameworks for Structure Determination of Encapsulated Guests

By @XtalEngineer, Michael D. Ward at Merck, @nyuniversity

Read the paper 👉 https://t.co/twAO5psokh

[ChemEurJ: Chemistry - A European Journal @ChemEurJ]

Guanidinium organosulfonate hydrogen-bonded frameworks can do it all: catalysis, selective encapsulation and control of tautomeric state (@MoTChaudhry, Justin Newman and Alfred Lee @XtalEngineer) #MerckChemistry https://t.co/Hhz6EEhVKV

[Alfred Lee @XtalEngineer]

Thank you @OPRD_ACS for highlighting our work on GS hydrogen-bonded frameworks in the recent installment of Some Items of Interest to Process R&D Chemists & Engineers. @nyumdi @CGD_ACS #MerckChemistry https://t.co/Pww6nN8X8E

[Alfred Lee @XtalEngineer]

A nice industry perspective on solid-state opportunities in tackling the evolving biopharmaceutical pipeline. Check it out! 👇

[Nature Chemical Engineering @NatChemEng]

🚨Online now!

An industry-led Comment highlighting opportunities in pharmaceutical crystallization with the shift towards isolating and purifying larger-sized larger molecules. @Bayer @EliLillyandCo @boehringerus @GileadSciences

Temporary link: https://t.co/UDG6fMxtES

[Alfred Lee @XtalEngineer]

Immense appreciation to the MRL Postdoctoral Research Fellowship Program #MerckChemistry @nyuchemistry #Crystallography #StructureDetermination
https://t.co/KQFBWBFS26

[Alfred Lee @XtalEngineer]

Very excited to share our work exploiting GS frameworks for structure elucidation of encapsulated guests in @ACSMatLett, @CGD_ACS & @ChemEurJ. The first two in collaboration with @aayusov, Allie Dillon & Mike Ward @nyumdi, & the latter led by @MoTChaudhry
https://t.co/3JOMoPCJV0

[Alfred Lee @XtalEngineer]

Huge thanks to the @NSF GOALI program and
https://t.co/XMl946urll

[Alfred Lee @XtalEngineer]

@MartinWard_xtal Two conferences in the fall that might be of interest to the organic solid-state community:
1) 25th ACT Larson Workshop
https://t.co/4FRTuZkwru
2) Pharma Crystallization Summit
https://t.co/zjr9Clvsqj