Very excited to share our work exploiting GS frameworks for structure elucidation of encapsulated guests in @ACSMatLett, @CGD_ACS & @ChemEurJ. The first two in collaboration with @aayusov, Allie Dillon & Mike Ward @nyumdi, & the latter led by @MoTChaudhry
https://t.co/3JOMoPCJV0
Role of molecular strain in crystallization―Organic crystal structures, which have long been utilized in industrial-scale crystallization, can sometimes undergo sudden and unexpected transitions to alternative, more thermodynamically stable arrangements, resulting in markedly different physical properties. In their article in @J_A_C_S, van de Streek, Neumann et al. present a method for calculating “molecular strain energy” to predict the likelihood that a molecule will adopt its most thermodynamically stable crystal packing arrangement. This study not only elucidates the unexpected crystallization of more stable, novel solid forms but also provides the pharmaceutical industry with a valuable tool for directing resources more effectively. Full article:
https://t.co/F4v383XNy7
Predicting the ritonavir crisis by revisiting the polymorph landscape with crystal structure prediction and form 4 structure solution https://t.co/aJZ49BTKfh
Our latest work in @ChemEurJ on combining high-throughput experimentation and powder X-ray diffraction to identify promising host-guest complexes for structure elucidation purposes.
Structure Elucidation of Pharmaceutically Relevant Compounds Within Pyrene-Based Frameworks (@MoTChaudhry, Justin Newman, Anisha Patel and Alfred Lee @XtalEngineer) #MerckChemistry https://t.co/inkhJfXTCG
The importance of surface composition and wettability on the dissolution performance of high drug loading amorphous dispersion formulations https://t.co/kVfSm9tSlZ
Unprecedented Packing Polymorphism of Oxindole: An Exploration Inspired by Crystal Structure Prediction (Alfred Lee, Xiaolong Zhu and co-workers) @XtalEngineer#MerckChemistry https://t.co/KvPExLhPZt
#MerckAnalytical is hiring. Come join us to create new automation capabilities to overcome scientific challenges related to preformulation and formulation development.
https://t.co/jMsfn2i5hz
Benchmarking Guanidinium Organosulfonate Hydrogen-Bonded Frameworks for Structure Determination of Encapsulated Guests
By @XtalEngineer, Michael D. Ward at Merck, @nyuniversity
Read the paper 👉 https://t.co/twAO5psokh
Guanidinium organosulfonate hydrogen-bonded frameworks can do it all: catalysis, selective encapsulation and control of tautomeric state (@MoTChaudhry, Justin Newman and Alfred Lee @XtalEngineer) #MerckChemistry https://t.co/Hhz6EEhVKV
Thank you @OPRD_ACS for highlighting our work on GS hydrogen-bonded frameworks in the recent installment of Some Items of Interest to Process R&D Chemists & Engineers. @nyumdi @CGD_ACS#MerckChemistry https://t.co/Pww6nN8X8E
🚨Online now!
An industry-led Comment highlighting opportunities in pharmaceutical crystallization with the shift towards isolating and purifying larger-sized larger molecules. @Bayer@EliLillyandCo@boehringerus@GileadSciences
Temporary link: https://t.co/UDG6fMxtES
Very excited to share our work exploiting GS frameworks for structure elucidation of encapsulated guests in @ACSMatLett, @CGD_ACS & @ChemEurJ. The first two in collaboration with @aayusov, Allie Dillon & Mike Ward @nyumdi, & the latter led by @MoTChaudhry
https://t.co/3JOMoPCJV0
@MartinWard_xtal Two conferences in the fall that might be of interest to the organic solid-state community:
1) 25th ACT Larson Workshop
https://t.co/4FRTuZkwru
2) Pharma Crystallization Summit
https://t.co/zjr9Clvsqj