Out now in @ThrombosisRese1
Our study showing the impact of allele-selective silencing of von Willebrand factor based on a single nucleotide allelic difference in VWF:
1) Thrombosis development is decreased
2) Bleeding times are not prolonged
https://t.co/bsHgfbbYzc
Allele-selective silencing of VWF using siRNAs is feasible based on 1 nucleotide difference within mouse strains. https://t.co/VexHGH4IAh #thrombosisandhemostasis#vascularbiology
Had a great time at the @nvth_nederland symposium. Grateful to present our data on allele-selective silencing of VWF in experimental bleeding and thrombosis models and to meet up with colleagues from all over the Netherlands. #NVTH2023 @TromboseLeiden
Honored to represent @TromboseLeiden by presenting our research on allele-selective #VWF inhibition at the #ISTH2022 and thankful that the abstract was recognized with an #ISTHEarlyCareer award.
Thankful for the opportunity to present my results on allele-selective inhibition of von Willebrand factor at the #DATS today and at the Dutch RNA Conference three weeks ago. Very nice to meet people in both the RNA and oligo field here in the Netherlands! @TromboseLeiden
Had an amazing week at the #NVTH2022 filled with amazing research on thrombosis and hemostasis. Honored for the opportunity to present my research on siRNA-mediated inhibition of VWF and very thankful for winning the NVTH abstract award! @nvth_nederland @TromboseLeiden
Honored to have the opportunity to present our results on allele-selective silencing of VWF with siRNAs at both the #NVTH2021 and the #11BIC this week!