Bruna Zaidan 🔬

Pathologist at Kidney Research Center - UFTM🔬Professor of Pathology 👩🏻‍🏫💜 Brazil 🇧🇷 #renalpath #GIpath

[Jonathan Zuckerman MD PhD @JZRenalPath]

Case of IgAN with massive hemispherical mesangial deposits. Mimics cryo-plugs but deposits are mesangial rather than filling capillary loops. #renalpath #pathwitter #nephrology

[Janira Navarro @Janiranavarro]

Arginase-1, HepPar1, Glypican-3
Strenghts and limitations

Dr. Chandan #USCAP25 #PathX #pathology

[Bruna Zaidan 🔬 @ZaidanBruna]

@AbhijitSurgPath @DrGeeONE 👏🏼👏🏼👏🏼

[Abhijit Das, MD @AbhijitSurgPath]

Celiac disease: Basic facts for residents
#CeliacDisease#
#HistoScoresGrades#
#BasicFactsForResidents#
#MakeSurgiPathEasy#

[Grace Choung, MD 박영이 @grace_choung]

Glomerular TMA (in this case 2/2 VEGF inhibitor)
•Fibrin thrombi
•Endothelial swelling
•Loss of endothelial fenestrations
•Subendothelial widening with electron lucent fluff
•Double contours
•Mesangiolysis
•Red blood cell fragments
#RenalPath #PathTwitter
(1/3)

[Arkana Laboratories @arkanalabs]

This painting shows glomeruli with nodular mesangial expansion and arterial hyalinosis, changes frequently seen in diabetic nephropathy. Diabetic nephropathy affects 30-40% of patients with diabetes mellitus, and is a major cause of end stage kidney disease in these patients.  

Painting by Dr. @Tiff_Caza

#NationalKidneyMonth #ArtofMedicine #CKDAwareness #DiabeticNephropathy

[Jonathan Zuckerman MD PhD @JZRenalPath]

Reminder that EM is still useful even when no gloms available. Example case of light chain deposition disease. IF highly suspicious with kappa restriction along TBMs; EM was helpful to confirm the diagnosis: powdery deposits on TBMs. #renalpath #nephrology #PathTwitter

[Bruna Zaidan 🔬 @ZaidanBruna]

@ziad_zaatari Great picture! 👏🏼👏🏼

[Nature Reviews Nephrology @NatRevNeph]

Pathological classification of HIV-associated kidney disease.

https://t.co/H4JCpk3ISL

[Tiffany Caza @Tiff_Caza]

Weekend paint project 🖌️🎨 . This is Alport syndrome by light microscopy. Overall, looks pretty normal except for some foci of interstitial foam cells. EM and genetics would tell us more.

[Renal Fellow Network @RenalFellowNtwk]

Kidney Comics: The "Urine" Casts #KidneyComics @momen_abbasi https://t.co/CJFOsktGo9

[Sanjeev Sethi @SethiRenalPath]

Teaching C1q in glomeruli on immunofluorescence microscopy.

My experience is if + it is real & is not non specific.

Positive:
1. Autoimmune disease=always +
2. Monoclonal Ig (PGNMID/MIDD)=often +
3. Infections= can be + or -

Negative:
1.IgA nephropathy
2.C3 glomerulopathy

[Arkana Laboratories @arkanalabs]

Today’s #eyeSCANdy shows an acellular scanning EM from a biopsy with membranous glomerulonephritis stage I, showing numerous small shallow depressions representing the site of immune complexes which were extracted.

Photo courtesy of Dr. Stephen Bonsib. #PathTwitter #PathX

[Pediatric Nephrology @Ped_Neph]

Alport syndrome is a genetically heterogenous disorder thought to be affecting only males. Read these Clinical Insights into a 15-yr-old female w/a rare pathogenic variant in the COL4A5 gene & X-linked Alport syndrome. #OpenAccess
https://t.co/N4jEOxeFtQ

[Sanjeev Sethi @SethiRenalPath]

1. Focal necrotizing lupus arteritis.
Plus severe lupus vasculopathy.

Can be missed and is unfortunately not part of the lupus classification.

2. Glomeruli showed mesangial lupus nephritis, class II.

40-yr old woman with lupus & rise in serum creatinine,+ lupus anticoagulant.

[Pathology mcqs @Pathology_mcqs]

Changes in the classification of GLIOMAS (Adult diffuse glioma) - WHO 2021 Classification of CNS tumors. #pathology #pathologymcq #neuropath #neuropathology #whocns #whocns2021 #pathtwitter #neurotwitter #neurology #pathboards

[Arkana Laboratories @arkanalabs]

💖 Love what you do 🔬 #Renal #RenalPath

[Sanjeev Sethi @SethiRenalPath]

Nuances of Membranous antigen staining:

1. PLA2R: granular staining along GBM
2. THSD7A: lumpy-discrete, scattered deposits along GBM (linear staining=negative)
3. EXT: granular staining along GBM, can be intense
4. NELL1: granular, can be segmental,sometimes appears linear. 1/2

[Jean Hou, MD @JeanHouMD]

The birth of a crescent....

[John Brealey @JohnBrealey]

#electronmicroscopy shows the plasticity of erythrocytes as they breach the peritubular capillary endothelium (two separate renal biopsy cases).