“I would advise any beginning writer to write the first draft as if no one else will ever read them – without a thought about publication – and only in the last draft to consider how the work will look from the outside.”
—Anne Tyler
@neely615 @Wybenga_Groot@UCDProteomics OH MYLANTA I have NO CONFLICTING MEETINGS. I'm locking my office door and ignoring any knocks, cries for help, or fire alarms. It has been too long.
Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out @NatureBiotech !
Read here👉: https://t.co/JZBYNzey1G
🔬 Highlights:
- Uses an experimental library of peptide markers integrated with a structural proteomics workflow.
- Probes the assembly state of hundreds of protein complexes simultaneously across conditions directly from whole cell extracts, informing on binding interface occupancy.
- Supports the structural modelling of protein complexes and the design of compounds targeting them
Congratulations to shared first authors @CathyMarulli and Christian Dörig and thanks to our collaborators @LabBarral and @TorstenSchwede lab
@ETH_en #Proteomics #PPIs #SystemsBiology #LiPMS #teammspec #DrugDiscovery
Rethink the analysis of DDA data! Blurring the boundary between DDA, WWA, and DIA, #MSFragger-DDA+ Enhances Peptide Identification Sensitivity with Full Isolation Window Search. Fully integrated in #FragPipe, simply annotate your DDA files as DDA+ and RUN. https://t.co/ThsqgTeqKw
The synuclein seeding assays are not enough to diagnose Parkinson and to differentiate it from PSP and MSA. Dr Edwin Jabbari @ucl makes a convincing argument that kinetics matter and combination assays will be the path forward. A combo assay that includes a 4R Tau assay has great potential. 1/3 of LRRK2 negative cases w/ current synuclein assay and also over 7% completely negative. Congrats on junior MDS award. #mdscongress #parkinsom
Working with my lab peeps and collaborator this week has, once again, reminded me why I love what I do and that I truly have the best "job" in the world.
I try not to brag about our papers when they come out, but for this one I make an exception. It is a clinical trial showing that our new drug combination is effective in pain patients. It will be published in Frontiers in Pain Research.
@ECUBrodySOM@ECUResearch@RLSFoundation
We are thrilled to share our latest preprint on the Anti-Müllerian Hormone and its unique signaling pathway. Our first ever cryo-EM structure represents a breakthrough over 40 years in the making. ��🔍
(@drewhow66)
Check out our findings here:
https://t.co/TXtegEbCBE
1/10
Very excited to see work from Hanna Budayeva included in this special issue of @JProteomeRes. Hanna has done a fantastic job leading our chemoproteomics efforts over the last few years - this story is just one of the exciting things her group is working on! Check out this issue!
@UCDProteomics Hmmmm....maybe there is a special test to establish this? Rack 5 boxes of tips in under a minute. Estimate the mM NaCl concentration in a saline solution to the nearest hundredth by taste. Strike fear in collegues with an eyebrow raise.
Important to de-stigmatize mental health efforts for Graduate Students.
How PhD students and other academics are fighting the mental-health crisis in science https://t.co/Nq9PZ5s5l5