Tonya Zeczycki

enzymologist | physical biochemist | director, BSOM's MS Core Facilities | studies IDPs, allostery, and redox in neurodegenerative diseases | opinions my own.

[Tonya Zeczycki @Zeczycki_Lab]

Working on some manuscripts and grants right now. Needed to see this.

[Dr Raul Pacheco-Vega @raulpacheco]

“I would advise any beginning writer to write the first draft as if no one else will ever read them – without a thought about publication – and only in the last draft to consider how the work will look from the outside.”
—Anne Tyler

[The Science of Parkinson's @ScienceofPD]

Abbvie @abbvie announces that their once-daily drug, tavapadon, improves #Parkinsons patient mobility in late-stage study
https://t.co/Kp2Jcxbhxl

[Dr. Erin Baker @ErinBakerIMS]

Check out the 2024 Emerging Investigators Issue for @J_ASMS. The future of mass spectrometry is definitely in good hands!!
https://t.co/ibYG5KfjEv

[Tonya Zeczycki @Zeczycki_Lab]

@neely615 @Wybenga_Groot @UCDProteomics OH MYLANTA I have NO CONFLICTING MEETINGS. I'm locking my office door and ignoring any knocks, cries for help, or fire alarms. It has been too long.

[Picotti Lab @Picotti_Lab]

Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out @NatureBiotech !

Read here👉: https://t.co/JZBYNzey1G

🔬 Highlights:

- Uses an experimental library of peptide markers integrated with a structural proteomics workflow.

- Probes the assembly state of hundreds of protein complexes simultaneously across conditions directly from whole cell extracts, informing on binding interface occupancy.

- Supports the structural modelling of protein complexes and the design of compounds targeting them

Congratulations to shared first authors @CathyMarulli and Christian Dörig and thanks to our collaborators @LabBarral and @TorstenSchwede lab

@ETH_en #Proteomics #PPIs #SystemsBiology #LiPMS #teammspec #DrugDiscovery

[Alexey Nesvizhskii @nesvilab]

Rethink the analysis of DDA data! Blurring the boundary between DDA, WWA, and DIA, #MSFragger-DDA+ Enhances Peptide Identification Sensitivity with Full Isolation Window Search. Fully integrated in #FragPipe, simply annotate your DDA files as DDA+ and RUN. https://t.co/ThsqgTeqKw

[Michael Okun @MichaelOkun]

The synuclein seeding assays are not enough to diagnose Parkinson and to differentiate it from PSP and MSA. Dr Edwin Jabbari @ucl makes a convincing argument that kinetics matter and combination assays will be the path forward. A combo assay that includes a 4R Tau assay has great potential. 1/3 of LRRK2 negative cases w/ current synuclein assay and also over 7% completely negative. Congrats on junior MDS award. #mdscongress #parkinsom

[Tonya Zeczycki @Zeczycki_Lab]

Working with my lab peeps and collaborator this week has, once again, reminded me why I love what I do and that I truly have the best "job" in the world.

[clemenslab @clemenslab]

I try not to brag about our papers when they come out, but for this one I make an exception. It is a clinical trial showing that our new drug combination is effective in pain patients. It will be published in Frontiers in Pain Research.
@ECUBrodySOM @ECUResearch @RLSFoundation

[Tonya Zeczycki @Zeczycki_Lab]

@neely615 @MagnusPalmblad @ProteomicsNews This is why it was so much fun to do!

[Tom Thompson Lab @ThompsonLab3]

We are thrilled to share our latest preprint on the Anti-Müllerian Hormone and its unique signaling pathway. Our first ever cryo-EM structure represents a breakthrough over 40 years in the making. ��🔍
(@drewhow66)

Check out our findings here:
https://t.co/TXtegEbCBE
1/10

[Tonya Zeczycki @Zeczycki_Lab]

@neely615 @ProteomicsNews This is making me realize I need to get....a passport. I know I know.

[Tonya Zeczycki @Zeczycki_Lab]

@neely615 Crap..yah sometimes it's later....

[Tonya Zeczycki @Zeczycki_Lab]

@neely615 What about the Biophys Society? (Note it is a big one)
https://t.co/QSGnjiamPV

Protein Society is a little too late (june)

[Christopher Rose @CMichaelRose]

Very excited to see work from Hanna Budayeva included in this special issue of @JProteomeRes. Hanna has done a fantastic job leading our chemoproteomics efforts over the last few years - this story is just one of the exciting things her group is working on! Check out this issue!

[Tonya Zeczycki @Zeczycki_Lab]

@UCDProteomics Hmmmm....maybe there is a special test to establish this? Rack 5 boxes of tips in under a minute. Estimate the mM NaCl concentration in a saline solution to the nearest hundredth by taste. Strike fear in collegues with an eyebrow raise.

[Tonya Zeczycki @Zeczycki_Lab]

@UCDProteomics Ohhhh maybe I will jump over and give it a try.

[Michael Trakselis @Trakselis]

Important to de-stigmatize mental health efforts for Graduate Students.
How PhD students and other academics are fighting the mental-health crisis in science https://t.co/Nq9PZ5s5l5