ZhuangLab

Xiaowei Zhuang's Lab at Harvard University and Howard Hughes Medical Institute

[ZhuangLab @ZhuangLab]

Explore the Global Pattern Browser: https://t.co/IRvmtMdE6T
Code: https://t.co/p18lUhyDk0

[ZhuangLab @ZhuangLab]

What is the global structure of cell-state space—and how do perturbations drive transitions within it?

Excited to share our new preprint (https://t.co/ZTlAY4eaJf), a work in collaboration with @JswLab.

[ZhuangLab @ZhuangLab]

Moreover, we perform a genome-scale Perturb-seq screen in human embryonic stem cells, validating and extending these findings and uncovering a class of mesenchymal transitions induced by diverse perturbations to cellular stress-response pathways.

[ZhuangLab @ZhuangLab]

Delighted to share this preprint from Prof. Rong Fan Lab @RongFan8 and Prof. Sidi Chen lab @sidichen on Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT. Congatulations, Alev, Xiaolong, Feifei, Paul, Sidi and Rong!

[Rong Fan @RongFan8]

Thrilled to share Perturb-DBiT — spatial unbiased in vivo perturb-seq with genome-scale CRISPR libraries! Hope you enjoy reading it over the Thanksgiving week 🥰 Kudos to @AlevBaysoy, Xiaolong, Feifei, and Paul. & collaboration with @sidichen, Hongbo Chi.
https://t.co/IcUPAG5k8P

[ZhuangLab @ZhuangLab]

Check out our preprint on Perturb-multi (https://t.co/lFeRYA0lco), a multi-year collaborative effort that enabled multi-modal in vivo genotype-phenotype mapping by pooled genetic perturbations and high-dimensionality phenotype readout by imaging and sequencing.

[William Allen @weallen1]

In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.

Check it out!
https://t.co/iJ8hi3ddz4