Wouter Saelens

Post-doc at Bart Deplancke lab @ EPFL

[Wouter Saelens @Zouters]

Still, there's much left to explore, as we "just" implemented two models here. We're working on integrating the sequence directly, and also thinking about interfacing with time dynamics tools. https://t.co/OaANye8Gih

[Wouter Saelens @Zouters]

Ever looked at your ATAC-seq signal and thought: there must be a better way to model this than peaks or windows? Happy to present ChromatinHD, a method that models scATAC+RNA data using the raw fragments. With @BartDeplancke @OlgaPushkarev https://t.co/OaANye8Gih

[Wouter Saelens @Zouters]

ChromatinHD is available at https://t.co/03JGOvptsc . It's still in beta, but you can already run the main models and interpretation tools. The full-featured package, interfacing with e.g. SCENIC+ @steinaerts, is coming soon. We're happy to hear any feedback.

[Wouter Saelens @Zouters]

@ZhijianLi3 Check out https://t.co/UIwT1QM7og @rcannood

[Freya Svedberg-Keating @FreyaRSvedberg]

The @NatImmunol perspective @MartinGuilliams and I wrote is out. We ask does tissue imprinting restrict macrophage plasticity? Using the lung as a case study we propose a revised model of macrophage plasticity. https://t.co/jqkgIoXisD

[Nature Biotechnology @NatureBiotech]

Generalizing RNA velocity to transient cell states through dynamical modeling https://t.co/rMPYMmEpOA

[Yvan Saeys @YvanSaeys]

Happy to be part of this project. Congratulations to @rcannood and @Zouters

[biohub @biohub]

#Opensource software is essential to science. That’s why we’re awarding 23 grants to support open source tools that accelerate biomedical research and serve the larger scientific community. https://t.co/djPyEZMRGy

[Dan Wagner @danwagnerlab]

With widespread adoption of single-cell-omics technologies, developmental biologists are increasingly relying on the use of “gene expression trajectories” to study cell differentiation. What is the difference between a trajectory and a lineage? (1/4)

[Koen Van den Berge @koenvdberge_Be]

Our work on differential expression (DE) analysis downstream of trajectory inference (TI) is now published! A small thread on a few changes we have added since the preprint.

https://t.co/BW6QqUCz72