Mechanisms of CD19 loss due to CD19-directed therapies. It's important to use multiple B-cell antigens and gating strategies to avoid missing these populations. From the plenary session talk by Erik Ames at #FlowICCS25#FlowEdu#HemePath
ISOLATED NEUTROPENIA
Saw a young white man in clinic today with isolated neutropenia. Went to brush up…and was struck by how little we actually know about this condition compared to anemia or thrombocytopenia. A diagnostic blind spot in hematology.
See: https://t.co/ESa7MjSbCP
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MILD, MODERATE, SEVERE... ACCORDING TO WHO?
I often notice MDs describing cytopenias as “mild,” “moderate,” or “severe” without reference to standard definitions.
The problem? Severity is in the eye of the beholder. Without shared definitions, these terms lose precision.
Just published: on behalf of the European LeukemiaNet, the international expert panel led by Prof Jane Apperley presented the 2025 management recommendations of chronic myeloid leukemia (CML) in LEUKEMIA @LeukemiaJnl open access.
https://t.co/m97NicZLcC
Just out: Mayo Clinic mSMART Risk Stratification of Myeloma
#EHA25
1/ We recommend and use same high risk cytogenetic definition as the latest IMS/IMWG paper
2/ Primary plasma cell leukemia is high risk myeloma
3/ We define Double-hit high risk myeloma
https://t.co/R4hz7umwEJ
But cytology has drawbacks like low sensitivity, subjectivity, sampling error, and pressure of reporting against time. Is there any better technique?
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Happy to share our recent article “Intraoperative flow cytometry in Gastric cancer” in Cytometry B
👇🏻
https://t.co/gOktTraMbw
Inotuzumab ozogamicin (INO) being an anti CD22 therapy, Which of these ����🏻refractory/Relapsed B-ALL patients are ideal for INO therapy.
Red - Blast.
Blue - Normal B lymphocytes.
Green - Normal T lymphocytes.
What is a blast?🤔
This is a deceptively simple question but the latest module from the ICCS Q&S Committee has all the answers! Get tips & detailed tables to identify normal & abnormal blast populations, and learn about potential pitfalls.
Check it out⬇️
https://t.co/yxIpUlEmcp
Join us (@IndMyAcGp) on 26 Dec 2024 Journal Club to discuss the role of Mass Spec & NGF in Multiple Myeloma MRD, followed by a Quiz. Also, send your commentaries for the Eagle Eye Competition (the date is extended till 22 Dec 2024). @DrPMPGI@MirghSumeet@DrAnilHandoo@NoemiPuigM
🚨New paper alert🚨
The prognostic value of MRD after CAR T cells and T cell engagers remained uncertain. Our study @AjHematology shows that MRD negative CR is the most relevant prognostic factor in this setting!
#mmsm@ClinicaNavarra@CIMA_unav@_pethema
https://t.co/AMtLfCZfis