ice9

I do quantitative things. Backup for __ice9.

[ice9 @__ice9_2]

Ironically not targeted via Birdwatch, but rather by an immediate automated check against some poorly-coded sentiment analysis.

It did not understand scare-quotes.

Case study in inept censorship.

Waiting out appeal for now.

[ice9 @__ice9_2]

@winocm The amount of dogma in favor of monoamine targeting as the solution to practically everything is unsettling.

I cannot tell how much is from drug company convenience vs. oversimplification by practitioners vs. historically more limited research vs. retconned existing practices.

[ice9 @__ice9_2]

Recent discussion reminded--

As noted before: sarcosine, a mere amino acid, outperformed popular SSRI antidepressant citalopram in head-to-head RCT
https://t.co/d9Hb9ye7JR

No side effects
https://t.co/E3D91uqXKw

Mechanism is enhanced glycine signaling
https://t.co/DiMEBfO0Cs

[ice9 @__ice9_2]

@winocm However: your point above again rather ominously suggests that the anti-monoaminergic and particularly anti-dopaminergic approach to the primary subject at hand may be fundamentally misguided in at least a considerable fraction of cases (many, many people report APs do not help).

[ice9 @__ice9_2]

@winocm It does not seem to have much of a viable alternative to the usual approaches, in most cases, overall. Some interesting blood pressure medication (guanfacine). A failed antidepressant (atomoxetine) for people with norepinephrine-specific issues. Rest is mainly just stimulants.

[ice9 @__ice9_2]

@winocm Generally

[ice9 @__ice9_2]

Interestingly sarcosine outperformed D-serine, a different co-agonist at the NMDA glutamate receptor, in schizophrenia studies.

Just anecdotally, I have noticed sarcosine seems much more useful than D-serine for depression as well. Again YMMV N=1 on this point.

[ice9 @__ice9_2]

Further: glycine itself is also effective in schizophrenia:
https://t.co/zNMONNf6ny

Benefit persists:
https://t.co/2YolQfVcNR

It is depleted in schizophrenia:
https://t.co/YRxWSJjyE1

Speculatively: may synergize with sarcosine (sarcosine seems to inhibit glycine transporter).

[ice9 @__ice9_2]

@winocm How common is visual snow?

[ice9 @__ice9_2]

@winocm Ffs yes it does

[ice9 @__ice9_2]

@winocm Hmm.

That would explain a lot.

Glycine is needed for NMDAR function as you alluded and NMDARs are cholinergic.

Recall what happens on too many anticholinergics.

I wonder whether effects could be further potentiated with exogenous glycine. Low BBB permeability but not zero.

[ice9 @__ice9_2]

@winocm @eiritana off-topic, apologies

hope the notes above were at least marginally useful, even if only in concurrence or less

[ice9 @__ice9_2]

@winocm @eiritana and yes it is one of the ~3 core reasons for the recent near-silence on the accounts

others: more general personal real-world economic-administrative-etc needs, and frustrated boredom with the tbh already-solved nature of the technical side of the typical subject, respectively