Ironically not targeted via Birdwatch, but rather by an immediate automated check against some poorly-coded sentiment analysis.
It did not understand scare-quotes.
Case study in inept censorship.
Waiting out appeal for now.
@winocm The amount of dogma in favor of monoamine targeting as the solution to practically everything is unsettling.
I cannot tell how much is from drug company convenience vs. oversimplification by practitioners vs. historically more limited research vs. retconned existing practices.
Recent discussion reminded--
As noted before: sarcosine, a mere amino acid, outperformed popular SSRI antidepressant citalopram in head-to-head RCT
https://t.co/d9Hb9ye7JR
No side effects
https://t.co/E3D91uqXKw
Mechanism is enhanced glycine signaling
https://t.co/DiMEBfO0Cs
@winocm However: your point above again rather ominously suggests that the anti-monoaminergic and particularly anti-dopaminergic approach to the primary subject at hand may be fundamentally misguided in at least a considerable fraction of cases (many, many people report APs do not help).
@winocm It does not seem to have much of a viable alternative to the usual approaches, in most cases, overall. Some interesting blood pressure medication (guanfacine). A failed antidepressant (atomoxetine) for people with norepinephrine-specific issues. Rest is mainly just stimulants.
Interestingly sarcosine outperformed D-serine, a different co-agonist at the NMDA glutamate receptor, in schizophrenia studies.
Just anecdotally, I have noticed sarcosine seems much more useful than D-serine for depression as well. Again YMMV N=1 on this point.
Further: glycine itself is also effective in schizophrenia:
https://t.co/zNMONNf6ny
Benefit persists:
https://t.co/2YolQfVcNR
It is depleted in schizophrenia:
https://t.co/YRxWSJjyE1
Speculatively: may synergize with sarcosine (sarcosine seems to inhibit glycine transporter).
@winocm Hmm.
That would explain a lot.
Glycine is needed for NMDAR function as you alluded and NMDARs are cholinergic.
Recall what happens on too many anticholinergics.
I wonder whether effects could be further potentiated with exogenous glycine. Low BBB permeability but not zero.
@winocm@eiritana and yes it is one of the ~3 core reasons for the recent near-silence on the accounts
others: more general personal real-world economic-administrative-etc needs, and frustrated boredom with the tbh already-solved nature of the technical side of the typical subject, respectively