Diego Balboa

Principal Investigator, Docent @helsinkiuni @HelsinkiUniMed @STEMMProgram . Interested in diabetes, genetics, stem cells and development.

[Davide Seruggia @DSeruggia]

Excited to share another recent paper from the lab, in collaboration with @lucapinello and @danielevanbauer. We leveraged allele distributions after dense editing to identify the regulatory potential of individual nucleotides within #enhancers:

https://t.co/aTKlNX7P6U

[bioRxiv Genomics @biorxiv_genomic]

Latent plasticity of the human pancreas across development, health, and disease. https://t.co/XSXqAUo7Me #biorxiv_genomic

[Kekäläinen Lab / Kekalainen Lab @KekalainenLab]

WE ARE HIRING 💥 Do you want to become our new project coordinator? More details on the University of Helsinki webpage. Application period until September 10th - be quick! https://t.co/aliWdOJMN9

[Daniel J Drucker @DanielJDrucker]

A HNF1A-A1CF transcription-splicing axis is suppressed in β cells from #T2D individuals, while genetic variants reducing pancreatic islet A1CF are associated with increased glycemia and T2D susceptibility https://t.co/jPa3vY8gY5

[Edgar_Bernardo @Edgar_Bernardo]

🚨Paper alert!!🚨

I am proud to announce that my postdoc work is now published in @Cell_Metabolism.

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

https://t.co/S8uiIhJSXS

[Katajisto Lab @KatajistoLab]

Proudly presenting Simon’s paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @NatMetabolism https://t.co/Vs3y6rGRek @helsinkiuni @HiLIFE_helsinki @SuomenAkatemia @MetaStem_Center

[Eliisa Vähäkangas @EliisaVhk]

Minor cell proportion shifts are unlikely to be the reason for the increased functionality upon engraftment. 2/5

[Eliisa Vähäkangas @EliisaVhk]

We report increased amounts of beta cells with high levels of MafA as well as overall increased mitochondrial content in beta cells. 3/5

[Eliisa Vähäkangas @EliisaVhk]

Glucose tracing experiments show increased incorporation of carbons into TCA-cycle intermediates, further highlighting the importance of mitochondrial metabolism for the increased functionality. 4/5

[Eliisa Vähäkangas @EliisaVhk]

We have previously reported SC-islets to have aberrant reactivity to pyruvate in vitro, which we now show is resolved upon implantation. A promising result as the maintenance of pyruvate reactive insulin secretion could lead to exercise induced hypoglycaemia. 5/5

[Eliisa Vähäkangas @EliisaVhk]

Why does it take SC-islets over 2-months to humanise mouse blood glucose when human islets achieve this feat a few weeks? This could be due to changes occurring to SC-islets upon engraftment. 1/5

[Eliisa Vähäkangas @EliisaVhk]

Excited to share our new research on the metabolic maturation of stem-cell-derived islets upon murine engraftement. Published today in @DiabetologiaJnl: https://t.co/rXpjkODy87
@OtonkoskiL @OtonkoskiT @KatajistoLab @MetaStem_Center @helsinkiuni
#SCislet #betacell #diabetes

[Fani García Ríos @fanygrc]

Si quieres estudiar la micobiota humana y su relación con diferentes patologías, en mi lab ofertamos un plan de formación JAEINT25_EX_0419 para unirte al proyecto MydGUT. Si eres estudiante de grado o máster te esperamos en el @iata_csic

[EISG 2025 @eisg2025]

On Session 2 of #EISG2025, we will hear about Metabolism in Islet Cells from:

- David Hodson (@daveyboyhod, U. Oxford)
- Jakob G Knudsen (@Alphacell_metab, U. Copenhagen)
- Hindrik Mulder (@hinmul, Lund U.)

Register now at https://t.co/mpcn31am1g
(Early bird until 13 March)

[La Revuelta @LaRevuelta_TVE]

Sin ciencia no hay futuro.

Cuando hablamos de CIENCIA, nos viene a la mente cosas como cohetes, pero la ciencia salva y mejora la vida de las personas.

#LaRevuelta @nh487

[SED Diabetes @SEDiabetes]

🔬 Nueva ayuda para investigar en #DM1 
La FSED y a Associació Ajuda a la Recerca en Diabetis - @arediabetis - lanzan la I Ayuda AREDI-FSED para proyectos de investigación básica en #diabetestipo1, dotada con 50.000 €.

Presenta tu solicitud 📄 antes del del 10/01/25
Más información 👉https://t.co/3d4YTTibzr

#DiabtESP #SEDiabetes #PCDM #PCDM1 #diabetes #InvestigacionDM

[Diego Balboa @_DiegoBalboa_]

@BPernaute @ERC_Research Fantastic news, congratulations @BPernaute ! So happy for you ;)

[Barbara Pernaute @BPernaute]

Really excited to share that I got an #ERCCoG from @ERC_Research The project EARLYFATE will explore the interplay between DNA damage responses and the very first events of mammalian development. Huge thanks to all colleagues, former mentors and lab members for their support!

[Jeffrey Millman @JeffreyRMillman]

We had a great 5th IPITA/HSCI/Breakthrough T1D meeting on Stem Cell-Derived Islets recently at Harvard Medical School! I am very excited about the direction this field is taking to develop cell replacement therapy for people living with #T1D.

[EISG 2025 @eisg2025]

Save the dates! June 11-13, 2025.

The European Islet Study Group Meeting of 2025 will take place in Malmö, Sweden hosted by our friends at Lund University Diabetes Centre.

#eisg2025 #islet #research #malmö